Results 11 to 20 of about 138,386 (251)

Structural variability and concerted motions of the T cell receptor – CD3 complex [PDF]

eLife, 2021
We investigate the structural and orientational variability of the membrane-embedded T cell receptor (TCR) – CD3 complex in extensive atomistic molecular dynamics simulations based on the recent cryo-EM structure determined by Dong et al., 2019.
Prithvi R Pandey, Bartosz Różycki, Reinhard Lipowsky, Thomas R Weikl   +3 more
doaj   +5 more sources

Structural Model of the Extracellular Assembly of the TCR-CD3 Complex [PDF]

Cell Reports, 2016
Antigen recognition of peptide-major histocompatibility complexes (pMHCs) by T cells, a key step in initiating adaptive immune responses, is performed by the T cell receptor (TCR) bound to CD3 heterodimers.
Aswin Natarajan, Vidushan Nadarajah, Klara Felsovalyi, Wenjuan Wang, Vivian R. Jeyachandran, Riley A. Wasson, Timothy Cardozo, Clay Bracken, Michelle Krogsgaard   +8 more
doaj   +5 more sources

Rigid crosslinking of the CD3 complex leads to superior T cell stimulation [PDF]

Frontiers in Immunology
Functionally bivalent non-covalent Fab dimers (Bi-Fabs) specific for the TCR/CD3 complex promote CD3 signaling on T cells. While comparing functional responses to stimulation with Bi-Fab, F(ab’)2 or mAb specific for the same CD3 epitope, we observed ...
Alfreda D. Nelson, Liangyu Wang, Kimberly G. Laffey, Laura R. E. Becher, Christopher A. Parks, Michele M. Hoffmann, Belinda K. Galeano, Ashutosh Mangalam, Emma Teixeiro, Emma Teixeiro, Tommi A. White, Adam G. Schrum, Adam G. Schrum, Adam G. Schrum, John F. Cannon, Diana Gil, Diana Gil, Diana Gil   +17 more
doaj   +2 more sources

The resting and ligand-bound states of the membrane-embedded human T-cell receptor–CD3 complex [PDF]

Nature Communications
The T-cell receptor (TCR) initiates T-lymphocyte activation, but the mechanism of TCR activation remains uncertain. Here, we present cryogenic electron microscopy structures for the unliganded and human leukocyte antigen (HLA)-bound human TCR–CD3 complex
Ryan Q. Notti, Fei Yi, Søren Heissel, Martin W. Bush, Zaki Molvi, Pujita Das, Henrik Molina, Christopher A. Klebanoff, Thomas Walz   +8 more
doaj   +2 more sources

Structural characterization of two γδ TCR/CD3 complexes

Nature Communications
The T-cell receptor (TCR)/CD3 complex plays an essential role in the immune response and is a key player in cancer immunotherapies. There are two classes of TCR/CD3 complexes, defined by their TCR chain usage (αβ or γδ). Recently reported structures have
Mohammed Hoque, John Benji Grigg, Trudy Ramlall, Jennifer Jones, Luke L. McGoldrick, John C. Lin, William C. Olson, Eric Smith, Matthew C. Franklin, Tong Zhang, Kei Saotome   +10 more
doaj   +3 more sources

Human CD3 complex is required for the generation of T-cell receptor-like chimeric antigen receptor targeting WT1 in natural killer cells [PDF]

Cancer Immunology, Immunotherapy
Chimeric antigen receptor-natural killer (CAR-NK) cells represent a promising cellular immunotherapy platform for various cancers, offering a favorable clinical safety profile and potential to generate off-the-shelf products. However, broader application
Sudjit Luanpitpong, Jirarat Poohadsuan, Parinya Samart, Xing Kang, Ponthip Pratumkaew, Montira Janan, Surapol Issaragrisil   +6 more
doaj   +2 more sources

In situ cell-surface conformation of the TCR-CD3 signaling complex

EMBO Reports
The extracellular molecular organization of the individual CD3 subunits around the αβ T cell receptor (TCR) is critical for initiating T cell signaling.
Aswin Natarajan, Yogambigai Velmurugu, Manuel Becerra Flores, Fatoumatta Dibba, Saikiran Beesam, Sally Kikvadze, Xiaotian Wang, Wenjuan Wang, Tianqi Li, Hye Won Shin, Timothy Cardozo, Michelle Krogsgaard   +11 more
doaj   +3 more sources

The TCR and LCK: foundations for T-cell activation and therapeutic innovation [PDF]

Frontiers in Immunology
The T cell receptor (TCR)-CD3 complex is crucial to adaptive immunity, driving antigen recognition and intracellular signaling cascades. CD3 subunits harbor key cytoplasmic motifs that recruit signaling proteins like LCK. While distal αβ TCR signaling is
Nadine M. Woessner, Nadine M. Woessner, Valeria Uleri, Valeria Uleri, Ondrej Stepanek, Susana Minguet, Susana Minguet, Susana Minguet   +7 more
doaj   +2 more sources

Molecular architecture of the αβ T cell receptor-CD3 complex. [PDF]

Proc Natl Acad Sci U S A, 2014
Significance The T-cell receptor (TCR) does not signal on its own. Instead, it is constitutively associated with the CD3 coreceptors, which contain intracellular signaling motifs. Although antigen (Ag) recognition by the TCR and the activation of T cells after CD3 activation have been extensively studied, there is far less known about how the
Birnbaum ME, Berry R, Hsiao YS, Chen Z, Shingu-Vazquez MA, Yu X, Waghray D, Fischer S, McCluskey J, Rossjohn J, Walz T, Garcia KC.   +11 more
europepmc   +4 more sources

Phosphoinositides regulate the TCR/CD3 complex membrane dynamics and activation. [PDF]

Sci Rep, 2018
AbstractPhosphoinositides (PIs) play important roles in numerous membrane-based cellular activities. However, their involvement in the mechanism of T cell receptor (TCR) signal transduction across the plasma membrane (PM) is poorly defined. Here, we investigate their role, and in particular that of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] in ...
Chouaki Benmansour N, Ruminski K, Sartre AM, Phelipot MC, Salles A, Bergot E, Wu A, Chicanne G, Fallet M, Brustlein S, Billaudeau C, Formisano A, Mailfert S, Payrastre B, Marguet D, Brasselet S, Hamon Y, He HT.   +17 more
europepmc   +4 more sources