Results 31 to 40 of about 138,386 (251)
TCR signaling emerges from the sum of many parts.
Frontiers in Immunology, 2012 How does T cell receptor signaling begin? Answering this question requires an understanding of how the parts of the molecular machinery that mediates this process fit and work together. Ultimately this molecular architecture must (i) trigger the relay of
Michael S Kuhns, Mark M Davis
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SLAMF6 compartmentalization enhances T cell functions
Life Science Alliance, 2023 After stimulation, the T cell co-receptor SLAMF6 colocalizes with the TCR–CD3 complex to enhance T cell activation. Targeting SLAMF6 localization and function with bispecific antibodies is a novel mechanism with potential therapeutic translation ...
Yevgeniya Gartshteyn +6 more
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MiRNAs which target CD3 subunits could be potential biomarkers for cancers. [PDF]
PLoS ONE, 2013 BACKGROUND: T-cells play an important role in the immune response and are activated in response to the presentation of antigens bound to major histocompatibility complex (MHC) molecules participating with the T-cell receptor (TCR).
Fariborz Asghari Alashti +1 more
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T lymphocyte density and distribution in human colorectal mucosa, and inefficiency of current cell isolation protocols. [PDF]
PLoS ONE, 2015 Mucosal tissues are critical immune effector sites containing complex populations of leukocytes in a tissue microenvironment that remains incompletely understood.
Gloria Cuevas Preza +4 more
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UBASH3A Regulates the Synthesis and Dynamics of TCR–CD3 Complexes [PDF]
The Journal of Immunology, 2019 Abstract The TCR–CD3 complex is a multicomponent membrane receptor, the expression of which is tightly regulated in thymocytes, as well as in mature T cells both at steady state and upon stimulation. In this study, we report novel roles for UBASH3A in TCR–CD3 synthesis and turnover.
Yan Ge +3 more
openaire +2 more sources
Frontiers in Immunology, 2015 The CD3ζ forms part of the T cell receptor (TCR) where it plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways leading to T cell effector functions.
Laura Jane Appleby +8 more
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Biophysical Characterization of CD6—TCR/CD3 Interplay in T Cells
Frontiers in Immunology, 2018 Activation of the T cell receptor (TCR) on the T cell through ligation with antigen-MHC complex of an antigen-presenting cell (APC) is an essential process in the activation of T cells and induction of the subsequent adaptive immune response.
Marjolein B. M. Meddens +9 more
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Pre-TCRα supports CD3-dependent reactivation and expansion of TCRα-deficient primary human T-cells
Molecular Therapy: Methods & Clinical Development, 2014 Chimeric antigen receptor technology offers a highly effective means for increasing the anti-tumor effects of autologous adoptive T-cell immunotherapy, and could be made widely available if adapted to the use of allogeneic T-cells.
Román Galetto +6 more
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Application of the immune-correcting therapy in complex treatment of surgical forms of erysipelas
Клінічна хірургія, 2021 Objective. To investigate the efficacy of immunomodulating and immunostimulating therapy in complex treatment of patients, suffering surgical forms of erysipelas.Materials and methods.
S. D. Shapoval +2 more
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The T Cell Receptor/CD3 Complex: A Dynamic Protein Ensemble [PDF]
Annual Review of Immunology, 1988 A large body of information about antigen receptors on the surface of T lymphocytes has been gathered in the last five years (1, 2). T cell receptors use a variable region gene pool that is completely distinct from the variable genes of immunoglobulins. Indeed, T cells recognize different antigenic entities than do B lymphocytes.
Clevers, J.C. +3 more
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