Results 1 to 10 of about 138,386 (251)

Reciprocal TCR-CD3 and CD4 Engagement of a Nucleating pMHCII Stabilizes a Functional Receptor Macrocomplex

Cell Reports, 2018
Summary: CD4+ T cells convert the time that T cell receptors (TCRs) interact with peptides embedded within class II major histocompatibility complex molecules (pMHCII) into signals that direct cell-fate decisions.
Caleb R. Glassman, Heather L. Parrish, Mark S. Lee, Michael S. Kuhns   +3 more
doaj   +1 more source

Nef-Mediated CD3-TCR Downmodulation Dampens Acute Inflammation and Promotes SIV Immune Evasion

Cell Reports, 2020
Summary: The inability of Nef to downmodulate the CD3-T cell receptor (TCR) complex distinguishes HIV-1 from other primate lentiviruses and may contribute to its high virulence.
Simone Joas, Ulrike Sauermann, Berit Roshani, Antonina Klippert, Maria Daskalaki, Kerstin Mätz-Rensing, Nicole Stolte-Leeb, Anke Heigele, Gregory K. Tharp, Prachi Mehrotra Gupta, Sydney Nelson, Steven Bosinger, Laura Parodi, Luis Giavedoni, Guido Silvestri, Daniel Sauter, Christiane Stahl-Hennig, Frank Kirchhoff   +17 more
doaj   +1 more source

T cell receptor engagement triggers its CD3epsilon and CD3zeta subunits to adopt a compact, locked conformation. [PDF]

PLoS ONE, 2008
How the T cell antigen receptor (TCR) discriminates between molecularly related peptide/Major Histocompatibility Complex (pMHC) ligands and converts this information into different possible signaling outcomes is still not understood.
Ruth M Risueño, Wolfgang W A Schamel, Balbino Alarcón   +2 more
doaj   +1 more source

Low expression of T-cell receptor-CD3 complex: a case with a clinical presentation resembling humoral immunodeficiency

The Turkish Journal of Pediatrics, 1996
Low expression of T-cell receptor-CD3 (TCR-CD3) complex, a rare cause of combined immunodeficiency, has only recently begun to be recognized. Here we report a four-year-old boy who has defective TCR-CD3 complex expression presenting with recurrent
O Sanal, L Yel, F Ersoy, I Tezcan, A I Berkel   +4 more
doaj  

Deep learning‐based image analysis reveals significant differences in the number and distribution of mucosal CD3 and γδ T cells between Crohn's disease and ulcerative colitis

The Journal of Pathology: Clinical Research, 2023
Colon mucosae of ulcerative colitis (UC) and Crohn's disease (CD) display differences in the number and distribution of immune cells that are difficult to assess by eye.
Elin Synnøve Røyset, Henrik P Sahlin Pettersen, Weili Xu, Anis Larbi, Arne K Sandvik, Sonja E Steigen, Ignacio Catalan‐Serra, Ingunn Bakke   +7 more
doaj   +1 more source

Transferrin Disassociates TCR from CD3 Signaling Apparatus to Promote Metastasis

Research
Immune recognition and activation by the peptide-laden major histocompatibility complex–T cell receptor (TCR)–CD3 complex is essential for anti-tumor immunity. Tumors may escape immune surveillance by dissembling the complex.
Ruomei Cheng, Xiaopeng Tang, Qiyu Zhao, Yuming Wang, Wenlin Chen, Gan Wang, Chenxi Wang, James Mwangi, Qiumin Lu, Dawit Adisu Tadese, Xudong Zhao, Caiwen Ou, Ren Lai   +12 more
doaj   +1 more source

A conserved CXXC motif in CD3epsilon is critical for T cell development and TCR signaling. [PDF]

PLoS Biology, 2009
Virtually all T cell development and functions depend on its antigen receptor. The T cell receptor (TCR) is a multi-protein complex, comprised of a ligand binding module and a signal transmission module.
Yibing Wang, Dean Becker, Tibor Vass, Janice White, Philippa Marrack, John W Kappler   +5 more
doaj   +1 more source

CD3 aptamers promote expansion and persistence of tumor-reactive T cells for adoptive T cell therapy in cancer

Molecular Therapy: Nucleic Acids
The CD3/T cell receptor (TCR) complex is responsible for antigen-specific pathogen recognition by T cells, and initiates the signaling cascade necessary for activation of effector functions.
Ashwathi Puravankara Menon, Helena Villanueva, Daniel Meraviglia-Crivelli, Hisse M. van Santen, Joschka Hellmeier, Angelina Zheleva, Francesca Nonateli, Timo Peters, Tassilo L.A. Wachsmann, Mercedes Hernandez-Rueda, Johannes B. Huppa, Gerhard J. Schütz, Eva Sevcsik, Beatriz Moreno, Fernando Pastor   +14 more
doaj   +1 more source

Joint Modeling of Immune Reconstitution Post Haploidentical Stem Cell Transplantation in Pediatric Patients With Acute Leukemia Comparing CD34+-Selected to CD3/CD19-Depleted Grafts in a Retrospective Multicenter Study

Frontiers in Immunology, 2018
Rapid immune reconstitution (IR) following stem cell transplantation (SCT) is essential for a favorable outcome. The optimization of graft composition should not only enable a sufficient IR but also improve graft vs.
Emilia Salzmann-Manrique, Emilia Salzmann-Manrique, Melanie Bremm, Sabine Huenecke, Milena Stech, Andreas Orth, Matthias Eyrich, Ansgar Schulz, Ruth Esser, Thomas Klingebiel, Peter Bader, Eva Herrmann, Ulrike Koehl, Ulrike Koehl, Ulrike Koehl   +14 more
doaj   +1 more source

T cell receptor signaling and cell immunotherapy

National Science Open
As the major sensor of adaptive immune system, T cell receptor (TCR) can recognize diverse antigens and initiate specific immune responses against invading pathogens and cancer cells.
Zhang Linsong, Xu Xinyi, Shi Xiaoshan, Xu Chenqi   +3 more
doaj   +1 more source