Results 91 to 100 of about 314,055 (282)

LncRNA Expression in CD4+ T Cells in Neurosyphilis Patients

Frontiers in Cellular and Infection Microbiology, 2017
Recent studies have shown that several long noncoding RNAs (lncRNAs) are involved in regulating the immune response to cope with pathogenic invasion. To date, the roles of lncRNAs in the CD4+ T cell response to Treponema pallidum (T.
Li-Li Liu, Shao-Gang Zhu, Xiao-Yong Jiang, Jun Ren, Yong Lin, Ning-Ning Zhang, Man-Li Tong, Hui-Lin Zhang, Wei-Hong Zheng, Hua-Jun Fu, Hai-Juan Luo, Li-Rong Lin, Jiang-Hua Yan, Tian-Ci Yang   +13 more
doaj   +1 more source

Changes in the Expression of Transcription Factors Involved in Modulating the Expression of EPO-R in Activated Human CD4-Positive Lymphocytes

PLoS ONE, 2013
We have recently described the presence of the erythropoietin receptor (EPO-R) on CD4(+) lymphocytes and demonstrated that its expression increases during their activation, reaching a level reported to be typical for erythroid progenitors. This observation suggests that EPO-R expression is modulated during lymphocyte activation, which may be important ...
Anna Mikosik, Joanna E. Frackowiak, Katarzyna A. Lisowska, Jacek M. Witkowski   +3 more
openaire   +5 more sources

Intraepithelial CD8-positive T lymphocytes predict survival for patients with serous stage III ovarian carcinomas: relevance of clonal selection of T lymphocytes

British Journal of Cancer, 2009
Background:The aim of this study was to investigate the prognostic effect of tumour-infiltrating lymphocytes (TILs) in serous stage III ovarian carcinoma to determine TIL clonality and to correlate this to Her2/neu expression.Methods:Formalin-fixed and ...
Michael P. H. Stumpf, A. Hasenburg, Riener Mo, Riener Mo, U. Jütting, C. Wang, C. Wang, Y. Shen, Y. Shen, M. Orlowska‐Volk, Pauline Fisch, Z. Wang, Gerald Gitsch, M. Werner, S. Lassmann   +14 more
semanticscholar   +1 more source

Dendrimer Conjugates with PD‐L1‐Binding Peptides Enhance In Vivo Antitumor Immune Response

Advanced Healthcare Materials, EarlyView.
In this paper, a novel nanoparticle scaffold composed of dendrimers conjugated with peptide‐based immune checkpoint inhibitors, enhancing drug delivery efficacy is introduced. By conjugating PD‐L1‐binding peptides to dendrimers, multivalent binding effects are harnessed, resulting in enhanced binding affinity, prolonged half‐life, and improved ...
DaWon Kim, Jin Woong Lee, Piper A. Rawding, Mari Iida, Carter Kim, Kourtney L. Kostecki, Michael J. Poellmann, Bridget Crossman, Ashley S. Liu, YoungSoo Kim, Deric L. Wheeler, Seungpyo Hong   +11 more
wiley   +1 more source

Prognostic significance of CD4-positive regulatory T cells in tumor draining lymph nodes from patients with bladder cancer

Heliyon, 2020
Introduction and methods: To clarify the role of CD4+ regulatory T cells in bladder cancer, we investigated the frequency of these cells in tumor draining lymph nodes of 50 patients with bladder cancer who underwent radical cystectomy using flow ...
Ali Ariafar, Yasmin Vahidi, Maryam Fakhimi, Ardalan Asadollahpour, Nasrollah Erfani, Zahra Faghih   +5 more
doaj  

Comparison of Tumor Microenvironments Between Primary Tumors and Brain Metastases in Patients With NSCLC

JTO Clinical and Research Reports, 2021
Introduction: This study investigates the immune profile of the primary lung tumors and the corresponding brain metastasis from patients with NSCLC using multiplex fluorescence immunohistochemistry.
Daiki Ikarashi, MD, PhD, Tamio Okimoto, MD, PhD, Takehito Shukuya, MD, PhD, Hiroko Onagi, MD, Takuo Hayashi, MD, PhD, Sara L. Sinicropi-Yao, PhD, Joseph M. Amann, PhD, Tetsuya Nakatsura, MD, PhD, Shigehisa Kitano, MD, PhD, David P. Carbone, MD, PhD   +9 more
doaj  

Increase of peripheral CXCR3 positive T lymphocytes upon treatment of RA patients with TNF-alpha inhibitors.

Rheumatology, 2005
OBJECTIVE To explore the regulation of factors involved in lymphocyte trafficking in patients with rheumatoid arthritis (RA) undergoing treatment with tumour necrosis factor alpha (TNF-alpha) inhibitors. METHODS We examined 14 consecutive patients with
D. Aeberli, M. Seitz, P. Jüni, P. Villiger   +3 more
semanticscholar   +1 more source

Engineered MSC Aggregates with E/N‐Cadherin and IL‐6 Preconditioning for the Treatment of Systemic Sclerosis

Advanced Healthcare Materials, EarlyView.
Engineered 3D‐Cad/IL6‐MSC, developed through synergistic hE/N‐cad‐Fc and IL‐6 preconditioning, show remarkable therapeutic potential for systemic sclerosis. These engineered MSC aggregates reduce pathogenic inflammatory cell infiltration and restore immune balance among CD4+ T‐cell populations, offering a promising approach to optimize MSC based ...
Yue Zhang, Mengyuan Qian, Yirui Shi, Jiaxu Cao, Min Xu, Xin Wen, Yunxia Yan, Sha Liu, Hongwei Chen, Shanshan Liu, Jun Yang, Lingyun Sun   +11 more
wiley   +1 more source

CD4+CD8+ Double-Positive T-Lymphocytes: Pitfalls

Turkish Journal of Hematology, 2020
İrfan Yavaşoğlu
doaj   +1 more source

Human Immunodeficiency Virus Type 1 (HIV-1) Infection of Herpesvirus Saimiri-Immortalized Human CD4-Positive T Lymphoblastoid Cells: Evidence of Enhanced HIV-1 Replication and Cytopathic Effects Caused by Endogenous Interferon-γ

, 1997
Herpesvirus saimiri (HVS) is a nonhuman primate gamma herpesvirus which can immortalize human T lymphocytes similar to Epstein–Barr virus immortalization of B cells.
K. Saha, M. Caruso, D. Volsky
semanticscholar   +1 more source