Results 151 to 160 of about 314,352 (325)

Expression of genes encoding cytotoxic cell-associated serine proteases in thymocytes [PDF]

, 2017
A family of homologous serine esterases designated granzyme A-H and the pore-forming protein perforin are present in cytoplasmic granules of mature peripheral cytolytic T lymphocytes and natural killer cells.
Held, Werner, MacDonald, H. Robson, Mueller, Christoph   +2 more
core  

Tryptophan Metabolite Indole‐3‐Aldehyde Induces AhR and c‐MYC Degradation to Promote Tumor Immunogenicity

Advanced Science, EarlyView.
Tryptophan metabolite Indole‐3‐aldehyde (I3A) downregulates cytosolic AhR and p‐ERK/c‐MYC proteins, together enhancing STAT3 phosphorylation and tumor immunogenicity. Overexpression of the Trp metabolic enzyme interleukin‐4‐induced gene‐1 (IL4I1) in tumor cells increases intracellular levels of I3A and enhances tumor immunogenicity.
Lei Cui, Zining Wang, Zixuan Guo, Hongxia Zhang, Yongxiang Liu, Huanling Zhang, Huan Jin, Feifei Xu, Xiaojuan Wang, Chunyuan Xie, Hui Guo, Tiantian Wang, Yanxun Lin, Qi Zhao, Penghui Zhou, Jing Tan, Jin‐Xin Bei, Peng Huang, Jinyun Liu, Xiaojun Xia   +19 more
wiley   +1 more source

Preoperative counts of CD4 T-lymphocytes and early postoperative infective complications in HIV-positive patients [PDF]

, 2002
D Savioz, Michael Chilcott, C Ludwig, M. Savioz, Laurent Kaiser, C Leissing, L Bühler, R Peter, P. Morel   +8 more
openalex   +1 more source

Potentiating the Efficacy of mRNA Vaccines through NIR‐II Imaging‐Guided Precise Vaccination

Advanced Science, EarlyView.
A supramolecular strategy is utilized to integrate IR780‐C16 lipids into conventional LNPs, pioneering a novel NIR‐II‐LNPs platform that elucidates the correlations between mRNA vaccines efficacy and vaccination parameters in a non‐invasive approach.
Mengfei Li, Xue Zheng, Xinyang Yu, Shaolong Qi, Shoujun Zhu, Guocan Yu, Songling Zhang   +6 more
wiley   +1 more source

The Antiviral Efficacy of the Murine Alpha-1 Interferon Transgene against Ocular Herpes Simplex Virus Type 1 Requires the Presence of CD4⁺, α/β T-Cell Receptor-Positive T Lymphocytes with the Capacity To Produce Gamma Interferon [PDF]

, 2002
Daniel J.J. Carr, Sansanee Noisakran
openalex   +1 more source

Populational composition of CD4⁺5RA/ CD4⁺5RO positive t lymphocytes and cytokine profile in children with allergic respiratory diseases

, 2021
A. I. Turyanskaya, Н. Г. Плехова, В. А. Сабыныч, E. V. Procekova   +3 more
openalex   +2 more sources

The LDH‐H3K18La‐Nur77 Axis Potentiates Immune Escape in Small Cell Lung Cancer

Advanced Science, EarlyView.
Lactate from SCLC tumors induces H3K18 lactylation in naïve CD8+ T cells, upregulating Nurr77 and enhancing tonic TCR signaling. This leads to T cell hyporesponsiveness to stimulation, impairing antitumor immunity and reducing immunotherapy efficacy.
Xiaoling Shang, Bo Cheng, Chenyue Zhang, Chenglong Zhao, Ruiqing Wang, Xun Zhang, Dizhi Jiang, Xinyu Zhang, Xinyue Ma, Hongyuan Mao, Zerun Li, Chenhan Huang, Tianzi Wang, Kaiyue Guo, Liwen Wang, Ning Tang, Haiyong Wang   +16 more
wiley   +1 more source

Relationships Between Phenotype and Function of Blood CD4+ T-Cells and Ascending Thoracic Aortic Aneurysm: an Experimental Study

Brazilian Journal of Cardiovascular Surgery
Introduction: Non-familial ascending thoracic aorta dilation and aneurysms (TAAs) are silent diseases in elderly patients. Histopathology revealed that functionally polarized infiltrating CD4+ T-cells play a key role in aortic wall weakening. Objective:
Silverio Sbrana, Kaushal Kishore Tiwari, Stefano Bevilacqua, Paola Giungato, Enkel Kallushi, Marco Solinas, Anna Maria Mazzone   +6 more
doaj   +1 more source

GENERATION OF CD4-POSITIVE SUPPRESSOR T CELLS FROM MIXED LYMPHOCYTE CULTURES IN THE PRESENCE OF INTERLEUKIN 2 RECEPTOR ANTIBODY TÜ69

, 1987
E. Marion Schneider, Graham Pawelec, Liangru Shi, Hans‐Jörg Bühring, Peter Wernet   +4 more
openalex   +1 more source

Supplementary Figure 1 from Increases in Absolute Lymphocytes and Circulating CD4⁺ and CD8⁺ T Cells Are Associated with Positive Clinical Outcome of Melanoma Patients Treated with Ipilimumab

, 2023
Alexander Martens, Kilian Wistuba‐Hamprecht, Jianda Yuan, Michael A. Postow, Phillip Wong, Mariaelena Capone, Gabriele Madonna, Amir Khammari, Bastian Schilling, Antje Sucker, Dirk Schadendorf, Peter Martus, Brigitte Dréno, Paolo A. Ascierto, Jedd D. Wolchok, Graham Pawelec, Claus Garbe, Benjamin Weide   +17 more
openalex   +1 more source