Results 151 to 160 of about 15,816,019 (291)

A practical flow cytometric approach to leukocyte immunophenotyping in guinea pigs and its potential applications in lymphoid neoplasia. [PDF]

Front Vet Sci
Štěpánová H, Jeklová E, Škorič M, Jarošová R, Jekl V.   +4 more
europepmc   +1 more source

CXCL3 Antagonism Reverses Systemic Antitumor Immune Memory Impairment Associated With High Tumor Burden and Sensitizes Anti‐PD‐1 Therapy

Advanced Science, EarlyView.
This study reveals that large tumors secrete more chemokine CXCL3, which recruits immunosuppressive neutrophils to the periphery, thereby impairing the activation and memory of systemic tumor‑reactive CD8+ T cells. CXCL3 antagonism restores systemic immune memory and enhances the antitumor efficacy of anti‑PD‑1 therapy, offering a potential strategy to
Ji Wang, Xinyu Tang, Zeju Li, Qi Qi, Chang Sun, Wen Sun, Weiya Zhang, Yue Yin, Ya Deng, Peiwen Ling, Yifan Xu, Guangshun Sun, Yi Ren, Hong Pan, Shui Wang, Wenbin Zhou   +15 more
wiley   +1 more source

<i>Porphyromonas gingivalis</i> promotes T-cell homing via the NF-κB/CXCR3 signaling pathway in experimental autoimmune encephalomyelitis. [PDF]

J Oral Microbiol
Dai D, Huang S, Cao G, Xu M, Cui B, Ma Q, Lin J.   +6 more
europepmc   +1 more source

Single‐Cell Transcriptomic Profiling Identifies B Cell‐Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia

Advanced Science, EarlyView.
This study generates the single‐cell atlas of pathogenic B‐cell subset Bc‐5 in ITP. It identifies RUNX3 as a key survival regulator and uncovers sphingolipid‐driven metabolic reprogramming, validating UGCG inhibition as a therapeutic candidate and building a valuable resource for ITP mechanistic and therapeutic exploration.
Dongmei Luo, Yanxia Zhan, Lili Ji, Pengcheng Xu, Pu Chen, Hao Pang, Yunan Ling, Fanli Hua, Xibing Zhuang, Hao Chen, Yunfeng Cheng   +10 more
wiley   +1 more source

FoxP3+ Regulatory T-Cells in Canine Cutaneous Lymphoma and Their Role in Immune Modulation. [PDF]

In Vivo
Semolin LMS, Anai LA, Jark PC, Munhoz TD, Cruvinel GG, Bitencourt RC, DA Rosa Sobreira MF, Camplesi AC, Leitão JR, Santana AE, Alves CEF.   +10 more
europepmc   +1 more source

Ex vivo EXPANSION AND CHARACTERIZATION OF EPSTEIN-BARR VIRUS-SPECIFIC CD4-POSITIVE BULK CYTOTOXIC T LYMPHOCYTES

Journal of the Japan Society of Blood Transfusion, 2004
Urushibara, Noriko, Yamada, Yoshiko, Miyazaki, Toru, Yamaguchi, Miki, Murahashi, Hideaki, Sekimoto, Tatsuya, Sato, Shin-ichiro, Kato, Toshiaki, Fujihara, Mitsuhiro, Azuma, Hiroshi, Ikeda, Hisami   +10 more
openaire   +2 more sources

Transformer‐Based Multitask Framework Integrating Habitat and Deep Learning for Predicting Early Disease Control and Survival in Immunotherapy‐Treated Hepatocellular Carcinoma

Advanced Science, EarlyView.
This study developed ECOS‐Net, a transformer‐based multitask framework integrating CT‐derived habitat and 2.5D deep learning features to simultaneously predict early disease control and overall survival in hepatocellular carcinoma patients treated with immune checkpoint inhibitors.
Xiaona Fu, Yusheng Guo, Bingxin Gong, Jie Lou, Ning Wang, Xuejun Chen, Hongtao Hu, Rundong Wang, Xiaofang Guo, Shanmei Li, Yangyang Xie, Shichao Long, Mengsi Li, Shubo Pan, Wen Shen, Zhaogang Zhang, Zifang Song, Pengchen Liang, Xiaoyun Liang, Peng Sun, Guilin Zhang, Shanshan Jiang, Jinxiang Zhang, Lian Yang   +23 more
wiley   +1 more source

Targeting Macrophage‐Mediated Lymphatic Immunosuppression to Prevent Tumor Recurrence After Microwave Ablation

Advanced Science, EarlyView.
Incomplete microwave ablation induces animmunosuppressive microenvironment in tumor‐draining lymph nodes. An albumin‐based lipoprotein nanosystem enables coordinated delivery of immunomodulators to tumor‐draining lymph nodes and residual tumors, reverses post‐ablation immunosuppression, suppresses residual tumor growth, and promotes durable antitumor ...
Xuexia Shan, Yuting Shen, Xiaodong Hou, Fengshan Jin, Shaoyue Li, Weichen Xu, Weiwei Ren, Xiaowan Bo, Qiuyan Li, Shuo Liu, Weifan Hao, Chengzhong Peng, Huixiong Xu, Liping Sun, Wenwen Yue   +14 more
wiley   +1 more source

Targeted next-generation sequencing in sepsis-associated lymphopenia: a concordance analysis with conventional microbiological testing. [PDF]

Front Cell Infect Microbiol
Xu Y, Ren J, Zheng Y, Huang L, Xie Y, Cui N.   +5 more
europepmc   +1 more source

An Adenoviral‐Vectored Tp0326 Vaccine Elicits Robust Functional Antibodies to Prevent Treponema pallidum Dissemination in a Rabbit Model

Advanced Science, EarlyView.
Vaccination promotes cellular infiltration into primary lesions and effectively inhibits T. pallidum dissemination to distal organs. Notably, transfer of lesion tissue from immunized animals fails to establish infection in naive recipients, confirming specific protective immunity.
Yinbo Jiang, Xinyuan Li, Lixia Huang, Xiangcai Zhang, Wujian Ke   +4 more
wiley   +1 more source