Results 321 to 330 of about 463,708 (346)

HLA‐DQ allele‐restricted activation of nitroso sulfamethoxazole‐specific CD4‐positive T lymphocytes from patients with cystic fibrosis

Clinical & Experimental Allergy, 2015
SummaryBackgroundFor certain HLA allele‐associated drug hypersensitivity reactions, the parent drug has been shown to associate directly with the risk allele. In other forms of hypersensitivity, HLA risk alleles have not been identified and T cells are activated in an allele unrestricted manner.
M O, Ogese, K, Saide, L, Faulkner, P, Whitaker, D, Peckham, A, Alfirevic, D M, Baker, A, Sette, M, Pirmohamed, B K, Park, D J, Naisbitt   +10 more
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A Review of CD4 Positive T Lymphocytes Counts among HIV Positive Patients Attending a Nigerian Teaching Hospital

British Microbiology Research Journal, 2015
Aims and Objectives: To determine the baseline CD4 positive T lymphocytes count of HIV/AIDS treatment naive adults clients presenting for the first time treatment in Benue State University Teaching Hospital. Subjects and Methods: A total of 700 subjects age between 18 years to 70 years, were recruited for the study, comprising 600 HIV sero-positive ...
S. Nwadioha, M. Odimayo, G. Jombo, E. Prince, M. Atef   +4 more
openaire   +1 more source

Circulatory CD4-Positive T-Lymphocyte Imbalance Mediated by Homocysteine-Induced AIM2 and NLRP1 Inflammasome Upregulation and Activation Is Associated with Human Abdominal Aortic Aneurysm

Journal of Vascular Research, 2020
<b><i>Introduction:</i></b> CD4-positive T lymphocytes (CD4 cells) play a significant role in human abdominal aortic aneurysm (AAA). However, we know little about the role of the different CD4 subtypes. <b><i>Objective:</i></b> We aimed to discover the circulatory CD4 phenotypic marker profile and the ...
Hao, Wang, Guodong, Wei, Shuai, Cheng, Ding, Wang, Ju, Ma, Shijie, Xin   +5 more
openaire   +2 more sources

Quantification of CD4-positive T lymphocytes

1995
Abstract Introduction The central lesion in HIV-induced immunodeficiency is the functional and numerical decrease in the CD4-positive population of T lymphocytes. Progressive loss of this key lymphoid population is associated with an increasing range and severity of cellular immunodeficiency and predisposition to ...
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Human T lymphocytes expressing the C3b/C4b complement receptor type one (CR1, CD35) belong to Fcγ receptor-positive CD4-positive T cells

Cellular Immunology, 1989
The phenotypic characteristics of human T lymphocytes expressing the C3b/C4b complement receptor type one (CR1, CD35) were investigated using dual-color surface immunofluorescence and cytofluorometric analysis of stained peripheral blood mononuclear cells (PBMC) from normal individuals.
J H, Cohen, J P, Aubry, J P, Revillard, J, Banchereau, M D, Kazatchkine   +4 more
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Removal of Autologous Activated CD4 Positive T Lymphocytes Also Result in Increased Colony-Forming Units (CFUs) in Patients with Myelodysplastic Syndromes.

Blood, 2009
Abstract Abstract 4862 Autologous activated CD4+ T lymphocytes (CD4+/CCR5+ double positive cells) in BMNC of 29 MDS patients were depleted or plused in in vitro cultures. That cultures with removed CD4+/CCR5+ cells exhibited significantly increased CFU generation.
Zheng Zhang, Xiao Li, Qingqiao Zhang, Qi He, Feng Xu, Lingyun Wu   +5 more
openaire   +1 more source

Resistance of CD4-positive T lymphocytes to etoposide-induced apoptosis mediated by upregulation of Bcl-xL expression in patients with HTLV-I-associated myelopathy

Journal of Neuroimmunology, 2001
Human T-lymphotropic virus type I (HTLV-I)-associated myelopathy (HAM) is characterized by chronic inflammation of the spinal cord. The exact mechanisms that enhance the development of chronic myelopathy remain to be determined. One such mechanism could be an altered response of peripheral blood CD4(+) T lymphocytes to apoptotic stimuli.
S, Hamasaki, T, Nakamura, T, Furuya, A, Kawakami, K, Ichinose, T, Nakashima, Y, Nishiura, S, Shirabe, K, Eguchi   +8 more
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[Clinicopathologic correlation between CD4-positive T lymphocyte counts and superficial lymphadenopathy in HIV-positive/AIDS patients].

Zhonghua bing li xue za zhi = Chinese journal of pathology, 2012
To explore the clinicopathological correlation between CD4(+) T lymphocyte count and superficial lymphadenopathy HIV/AIDS patients.A total of 1066 HIV/AIDS patients were included in this study. The incidence of superficial lymphadenopathy, peripheral blood CD4(+) T lymphocyte counts and histological features of superficial lymphadenopathy were analyzed.
Xiang-chan, Lu, Jian-ning, Deng, Ai-chun, Huang, Xue-qin, Li, Min-hong, Mou, Ru-zhi, Ou, Lei, Huang, Min, Zhao   +7 more
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Modeling Changes in CD4-positive T-Lymphocyte Counts after the Start of Highly Active Antiretroviral Therapy and the Relation with Risk of Opportunistic Infections The Aquitaine Cohort, 1996–1997

American Journal of Epidemiology, 2001
Abstract After initiation of a treatment for human immunodeficiency virus type 1 infection containing a protease inhibitor, immune restoration associated with increases in CD4-positive (CD4+) T lymphocyte count may be delayed. In a sample of patients who had been prescribed protease inhibitors for the first time, the authors tested to ...
C, Binquet, G, Chêne, H, Jacqmin-Gadda, V, Journot, M, Savès, D, Lacoste, F, Dabis   +6 more
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Peptide specificity of alloreactive CD4 positive T lymphocytes directed against a major histocompatibility complex class I disparity.

Transplantation, 1997
The mouse strains C57BL/6 (B6, H2b) and Kbm1 mutant bm1 have a defined difference of three amino acids at position 152, 155, and 156 in the MHC class I K molecule. This causes a change in the side and the bottom of the antigen presenting groove of the K molecule resulting in strong allogeneic responses in vitro and in vivo.
M A, Ossevoort, M L, De Bruijn, K J, Van Veen, W M, Kast, C J, Melief   +4 more
openaire   +1 more source