Results 211 to 220 of about 1,048,882 (334)

Large neutral amino acid uptake and mTOR activation within CD4 T cells coordinate type 2 immunity and host resistance to <i>Trichuris muris</i>. [PDF]

open access: yesDiscov Immunol
Krauss MZ   +7 more
europepmc   +1 more source

Allogeneic Immune Cell Perfusion Inhibits the Growth of Vascularized 3D In Vitro Tumor Models, Induces Vascular Regression and Desmoplasia, but Promotes Tumor Cell Invasion

open access: yesAdvanced Science, EarlyView.
This study presents a vascularized 3D tumor model to investigate immune–stromal–tumor interactions under allogeneic PBMC perfusion. While immune cells induced tumor shrinkage, they also promoted vascular regression, stromal activation, and cancer cell invasion.
Alexandra Raab   +8 more
wiley   +1 more source

Enumeration, Phenotyping, and Clinical Associations of Tissue-Resident T Cells in the Ecto- and Endocervix of Women Attending a Colposcopy Clinic. [PDF]

open access: yesAm J Reprod Immunol
Ssemaganda A   +17 more
europepmc   +1 more source

CONTENTS OF CD4<sup>+</sup> AND CD8<sup>+</sup> EFFECTOR MEMORY CELLS AND PROLIFERATIVE ACTIVITY OF T LYMPHOCYTES IN BRONCHIAL ASTHMA

open access: diamond, 2019
M. Sh. Barkovskaya   +6 more
openalex   +2 more sources

Irradiated Tumor Cell‐Derived Microparticles Activate Systemic Anti‐Tumor Immunity via the STING/NLRP3/GSDMD Axis in Neutrophils

open access: yesAdvanced Science, EarlyView.
Radiotherapy induces tumor cells to release microparticles (RT‐MPs) into the circulation. The mitochondrial DNA carried by these RT‐MPs activates the STING/NLRP3/GSDMD axis in splenic neutrophils, triggering IL‐1β secretion. This, in turn, enhances dendritic cell function and facilitates the formation of cytotoxic T lymphocytes, thereby promoting ...
Yan Hu   +18 more
wiley   +1 more source

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

open access: yesAdvanced Science, EarlyView.
ABSTRACT While the function of biglycan (BGN) is recognized in various cancers, its precise role and the mechanisms underlying cancer‐associated fibroblasts (CAFs) formation within the melanoma tumor microenvironment (TME) remain poorly understood. Utilizing spatial transcriptomics, single‐cell RNA sequencing (scRNA‐seq), vitro/vivo assays, function ...
Hao‐ze Shi   +16 more
wiley   +1 more source

A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T cell signaling and differentiation. [PDF]

open access: yesJ Exp Med
Golec DP   +23 more
europepmc   +1 more source

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