Large neutral amino acid uptake and mTOR activation within CD4 T cells coordinate type 2 immunity and host resistance to <i>Trichuris muris</i>. [PDF]
Krauss MZ +7 more
europepmc +1 more source
Oscillation of the human immunodeficiency virus surface receptor is regulated by the state of viral activation in a CD4+ cell model of chronic infection [PDF]
Salvatore T. Butera +4 more
openalex +1 more source
This study presents a vascularized 3D tumor model to investigate immune–stromal–tumor interactions under allogeneic PBMC perfusion. While immune cells induced tumor shrinkage, they also promoted vascular regression, stromal activation, and cancer cell invasion.
Alexandra Raab +8 more
wiley +1 more source
Enumeration, Phenotyping, and Clinical Associations of Tissue-Resident T Cells in the Ecto- and Endocervix of Women Attending a Colposcopy Clinic. [PDF]
Ssemaganda A +17 more
europepmc +1 more source
Radiotherapy induces tumor cells to release microparticles (RT‐MPs) into the circulation. The mitochondrial DNA carried by these RT‐MPs activates the STING/NLRP3/GSDMD axis in splenic neutrophils, triggering IL‐1β secretion. This, in turn, enhances dendritic cell function and facilitates the formation of cytotoxic T lymphocytes, thereby promoting ...
Yan Hu +18 more
wiley +1 more source
Beyond the Th2 paradigm: CD4+ cytotoxic T lymphocytes as key drivers of tissue damage and fibrosis in IgG4-related disease. [PDF]
Yi J, Jia L, Mao T, Li Z.
europepmc +1 more source
HIV-spezifische CD4 T-Zell-Antworten in der akuten HIV-Infektion
Miriam Schieffer
openalex +1 more source
ABSTRACT While the function of biglycan (BGN) is recognized in various cancers, its precise role and the mechanisms underlying cancer‐associated fibroblasts (CAFs) formation within the melanoma tumor microenvironment (TME) remain poorly understood. Utilizing spatial transcriptomics, single‐cell RNA sequencing (scRNA‐seq), vitro/vivo assays, function ...
Hao‐ze Shi +16 more
wiley +1 more source
A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T cell signaling and differentiation. [PDF]
Golec DP +23 more
europepmc +1 more source

