Results 221 to 230 of about 574,897 (264)
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Current Opinion in Immunology, 1991
The three-dimensional structure of the binding domain of the CD4 molecule has been determined and extensive mutational analyses of the respective binding sites on gp120 and CD4 have been completed. The consequences of gp120-CD4 binding with respect to secondary changes in the virion, or the cell, that may be required for infection or that may interfere
J S, McDougal +2 more
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The three-dimensional structure of the binding domain of the CD4 molecule has been determined and extensive mutational analyses of the respective binding sites on gp120 and CD4 have been completed. The consequences of gp120-CD4 binding with respect to secondary changes in the virion, or the cell, that may be required for infection or that may interfere
J S, McDougal +2 more
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Idiopathic CD4 lymphocytopenia
Current Opinion in Rheumatology, 2006A severe decrease of CD4 T cells predisposes humans to opportunistic infections. In adults, HIV is certainly the most common cause of CD4 lymphocytopenia, but other causes, such as infections, autoimmune diseases, immunosuppressive therapy, lymphoma and idiopathic forms need to be considered.
Walker, Ulrich A., Warnatz, Klaus
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Idiopathic CD4 lymphocytopenia
Allergy and Asthma Proceedings, 2016Idiopathic CD4 lymphocytopenia (ICL) is a rare disorder of unknown etiology. Diagnostic criteria include a persistent CD4 T-cell lymphopenia with no underlying primary or secondary immune deficiencies and a CD4 T-cell count of 300 cells/mL or 20% total lymphocyte on multiple occasions.To increase awareness of ICL and to provide a review of the clinical
Joel P, Brooks, Gisoo, Ghaffari
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Cd4+ T cell apoptosis induced by anti-CD4 antibodies
Current Medical Science, 2000To explore the inhibitory effects of anti-CD4 human/murine chimeric antibodies on lymphocyte proliferation, CD4+ T cell apoptosis induced by anti-CD4 antibodies was examined. Annexin-V-FITC and PI double stain method was employed to qualitatively and quantitatively determined CD4+ T cell apoptosis induced by anti-CD4 antibodies. Our results showed that
Z, Zhang +4 more
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CD4 and the Immunopathology of AIDS
American Journal of Respiratory Cell and Molecular Biology, 1989Since its original description as a lymphoycte differentiation antigen in 1980, much has been learned about the cell surface glycoprotein CD4. Initially identified on T lymphocytes with helper/inducer function, CD4 has a wider distribution and is present on some T lymphocytes with suppressor, cytotoxic, or macrophage-activating function.
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1996
The CD4 molecule plays an important role in the development of CD4+T lymphocytes and it also acts as a coreceptor to enhance responses mediated via the TCR. It is now established that CD4 functions both as an adhesion molecule favoring the T cell: APC interaction and as a signaling molecule.
K S, Ravichandran +2 more
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The CD4 molecule plays an important role in the development of CD4+T lymphocytes and it also acts as a coreceptor to enhance responses mediated via the TCR. It is now established that CD4 functions both as an adhesion molecule favoring the T cell: APC interaction and as a signaling molecule.
K S, Ravichandran +2 more
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Rheumatic Disease Clinics of North America, 1998
Animal models of human autoimmune disease suggest that it should be possible to reinduce self-tolerance in these conditions by the use of T-cell directed therapies, in particular with anti-CD4 monoclonal antibodies (CD4-mAb). Many studies have shown that CD4-mAb can prevent and in a treatment setting suppress activity of these disease models, including
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Animal models of human autoimmune disease suggest that it should be possible to reinduce self-tolerance in these conditions by the use of T-cell directed therapies, in particular with anti-CD4 monoclonal antibodies (CD4-mAb). Many studies have shown that CD4-mAb can prevent and in a treatment setting suppress activity of these disease models, including
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Endocytosis and recycling of CD4
Biochemical Society Transactions, 1990Marsh, M, Armes, JE, Pelchenmatthews, A
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