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Cd4+ T cell apoptosis induced by anti-CD4 antibodies
Current Medical Science, 2000To explore the inhibitory effects of anti-CD4 human/murine chimeric antibodies on lymphocyte proliferation, CD4+ T cell apoptosis induced by anti-CD4 antibodies was examined. Annexin-V-FITC and PI double stain method was employed to qualitatively and quantitatively determined CD4+ T cell apoptosis induced by anti-CD4 antibodies. Our results showed that
Z, Zhang +4 more
openaire +2 more sources
1996
The CD4 molecule plays an important role in the development of CD4+T lymphocytes and it also acts as a coreceptor to enhance responses mediated via the TCR. It is now established that CD4 functions both as an adhesion molecule favoring the T cell: APC interaction and as a signaling molecule.
K S, Ravichandran +2 more
openaire +2 more sources
The CD4 molecule plays an important role in the development of CD4+T lymphocytes and it also acts as a coreceptor to enhance responses mediated via the TCR. It is now established that CD4 functions both as an adhesion molecule favoring the T cell: APC interaction and as a signaling molecule.
K S, Ravichandran +2 more
openaire +2 more sources
Rheumatic Disease Clinics of North America, 1998
Animal models of human autoimmune disease suggest that it should be possible to reinduce self-tolerance in these conditions by the use of T-cell directed therapies, in particular with anti-CD4 monoclonal antibodies (CD4-mAb). Many studies have shown that CD4-mAb can prevent and in a treatment setting suppress activity of these disease models, including
openaire +2 more sources
Animal models of human autoimmune disease suggest that it should be possible to reinduce self-tolerance in these conditions by the use of T-cell directed therapies, in particular with anti-CD4 monoclonal antibodies (CD4-mAb). Many studies have shown that CD4-mAb can prevent and in a treatment setting suppress activity of these disease models, including
openaire +2 more sources
Endocytosis and recycling of CD4
Biochemical Society Transactions, 1990Marsh, M, Armes, JE, Pelchenmatthews, A
openaire +4 more sources
In Vivo CD4 + T Cell Differentiation and Function: Revisiting the Th1/Th2 Paradigm
Annual Review of Immunology, 2020Marion Pepper
exaly
Landscape of helper and regulatory antitumour CD4+ T cells in melanoma
Nature, 2022Samuel S Freeman +2 more
exaly