Results 1 to 10 of about 25,017 (220)

HIV gp120 induces TREM1 expression through TLR–PGE₂ signalling in human monocyte-derived microglia [PDF]

Journal of Neuroinflammation
Microglia serve as a long-lived reservoir for HIV in the brain and are resistant to the cytopathic effects of infection. As such, they pose a significant barrier to eradication strategies and contribute to chronic neuroinflammation in people living with ...
Ayisha Mahama, Pratima Rawat, Carmen Teodorof-Diedrich, Stephen A. Spector, Grant R. Campbell   +4 more
doaj   +2 more sources

The influence of N-linked glycans on the molecular dynamics of the HIV-1 gp120 V3 loop. [PDF]

PLoS ONE, 2013
N-linked glycans attached to specific amino acids of the gp120 envelope trimer of a HIV virion can modulate the binding affinity of gp120 to CD4, influence coreceptor tropism, and play an important role in neutralising antibody responses.
Natasha T Wood, Elisa Fadda, Robert Davis, Oliver C Grant, Joanne C Martin, Robert J Woods, Simon A Travers   +6 more
doaj   +8 more sources

Quercetin ameliorates HIV-1 gp120 protein-induced intestinal barrier dysfunction by inhibiting the activation of the ERK1/2 signaling pathway in a Caco-2 cell model [PDF]

AIDS Research and Therapy
Background People living with HIV (PLWH) frequently experience non-AIDS comorbidities, driven in part by persistent intestinal barrier dysfunction and systemic inflammation.
Lijiao Zhu, Jiangyu Yan, Qinghui Wang, Xiaoqing He, Xiaolei Xu, Jiadan Yang, Jing Ouyang   +6 more
doaj   +2 more sources

Highly efficient production of HIV-1AD8 gp120 in mammalian cells [PDF]

Journal of Virology
Human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins (Envs) interact with the CD4 receptor and CCR5/CXCR4 coreceptor expressed on target cells to mediate viral entry. Infection is initiated when the HIV-1 gp120 subunit of Envs binds to host
Tanvi Mathur, Shamim Ahmed, Durgadevi Parthasarathy, Alon Herschhorn   +3 more
doaj   +2 more sources

Human immunodeficiency virus 1 glycoprotein 120 induces endoplasmic reticulum stress in neurons [PDF]

Cell Death and Disease
People living with Human Immunodeficiency Virus (HIV) (PLWH) may develop HIV-associated neurocognitive disorder (HAND) despite the use of antiretroviral therapy.
Christy Agbey, Lee A. Campbell, Thieu Phan, Gerard Ahern, Italo Mocchetti   +4 more
doaj   +2 more sources

CD4‐Based Chimeric Antigen Receptor (CAR)‐T Cells With Resistance to HIV‐1 Infection and Enhanced Anti‐HIV Efficacy: Covalent Interaction Between CD4‐CAR and HIV‐1 Envelope Glycoprotein [PDF]

J Med Virol
ABSTRACT The current highly active antiretroviral therapy (HAART or ART) effectively suppresses de novo HIV‐1 infection but fails to eliminate HIV reservoir cells, which leads to rapid viral rebound upon ART cessation. Chimeric antigen receptor (CAR) T cells engineered to target HIV‐1 Env⁺ cells offer a promising strategy to eliminate or control these ...
Lou Y, He X, Li G, Sikhondze M, Ma J, Du H, Ouyang X, Dotti G, Sajadi M, Su L.   +9 more
europepmc   +2 more sources

Immune non-response despite effective antiretroviral therapy in people living with HIV: A review of potential mechanisms, biomarkers and therapeutic approaches. [PDF]

HIV Med
Abstract Introduction A proportion of people living with HIV (PLWH) fail to restore their CD4 count or their CD4/CD8 ratio despite effective antiretroviral therapy (ART). PLWH with immune non‐response (INR) are at a higher risk of both AIDS and non‐AIDS events. The underlying mechanisms of INR remain unclear.
Silvestre C, Gross A, Makinson A.
europepmc   +2 more sources

Immunogenicity and protection mediated by dmLT and alum adjuvants for an HIV-1 vaccine [PDF]

Frontiers in Immunology
The development of an effective HIV-1 vaccine is of paramount importance to global health. Here, we compared the influence of two adjuvants, Escherichia coli double-mutant heat-labile toxin (dmLT) and alum, on the protective immunity induced by a ...
Kasey Stokdyk, Kasey Stokdyk, Anusmita Sahoo, Anusmita Sahoo, Sailaja Gangadhara, Sailaja Gangadhara, LaTonya D. Williams, LaTonya D. Williams, Tiffany M. Styles, Tiffany M. Styles, Caleb A. Hellman, Caleb A. Hellman, Lu Zhang, Lu Zhang, Ahmad J. Odeh, Ahmad J. Odeh, Shelby Flaherty, Xiaoying Shen, Mohammad Arif Rahman, Elizabeth B. Norton, Genoveffa Franchini, David Montefiori, Pamela A. Kozlowski, Georgia D. Tomaras, Georgia D. Tomaras, Rama Rao Amara, Rama Rao Amara   +26 more
doaj   +2 more sources

HIV envelope antigen valency on peptide nanofibers modulates antibody magnitude and binding breadth

Scientific Reports, 2021
A major challenge in developing an effective vaccine against HIV-1 is the genetic diversity of its viral envelope. Because of the broad range of sequences exhibited by HIV-1 strains, protective antibodies must be able to bind and neutralize a widely ...
Chelsea N. Fries, Jui-Lin Chen, Maria L. Dennis, Nicole L. Votaw, Joshua Eudailey, Brian E. Watts, Kelly M. Hainline, Derek W. Cain, Richard Barfield, Cliburn Chan, M. Anthony Moody, Barton F. Haynes, Kevin O. Saunders, Sallie R. Permar, Genevieve G. Fouda, Joel H. Collier   +15 more
doaj   +1 more source

Discovery of O-Linked Carbohydrate on HIV-1 Envelope and Its Role in Shielding against One Category of Broadly Neutralizing Antibodies

Cell Reports, 2020
Summary: Approximately 50% of the mass of the Envelope (Env) glycoprotein surface subunit (gp120) of human immunodeficiency virus type 1 (HIV-1) is composed of N-linked carbohydrate. Until now, the dogma has been that HIV-1 lacks O-linked carbohydrate on
Zachary A. Silver, Aristotelis Antonopoulos, Stuart M. Haslam, Anne Dell, Gordon M. Dickinson, Michael S. Seaman, Ronald C. Desrosiers   +6 more
doaj   +1 more source