HIV gp120 induces TREM1 expression through TLR–PGE₂ signalling in human monocyte-derived microglia [PDF]
Journal of NeuroinflammationMicroglia serve as a long-lived reservoir for HIV in the brain and are resistant to the cytopathic effects of infection. As such, they pose a significant barrier to eradication strategies and contribute to chronic neuroinflammation in people living with ...
Ayisha Mahama +4 more
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Human immunodeficiency virus envelope protein Gp120 induces proliferation but not apoptosis in osteoblasts at physiologic concentrations. [PDF]
PLoS ONE, 2011 Patients with HIV infection have decreased numbers of osteoblasts, decreased bone mineral density and increased risk of fracture compared to uninfected patients; however, the molecular mechanisms behind these associations remain unclear.
Nathan W Cummins +6 more
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Insights from the interfaces of HIV-1 envelope (ENV) trimer viral protein GP160 (GP120-GP41)
International Journal of Research in Pharmaceutical Sciences, 2021 The Human Immunodeficiency Virus (HIV-1) type 1 viral protein is a life threatening virus causing HIV/AIDS in infected humans. The HIV-1 envelope (ENV) trimer glycoprotein GP160 (GP120-GP41) is gaining attention in recent years as a potential vaccine ...
Christina Nilofer, Arumugam Mohanapriya
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HIV envelope antigen valency on peptide nanofibers modulates antibody magnitude and binding breadth
Scientific Reports, 2021 A major challenge in developing an effective vaccine against HIV-1 is the genetic diversity of its viral envelope. Because of the broad range of sequences exhibited by HIV-1 strains, protective antibodies must be able to bind and neutralize a widely ...
Chelsea N. Fries +15 more
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Cell Reports, 2020 Summary: Approximately 50% of the mass of the Envelope (Env) glycoprotein surface subunit (gp120) of human immunodeficiency virus type 1 (HIV-1) is composed of N-linked carbohydrate. Until now, the dogma has been that HIV-1 lacks O-linked carbohydrate on
Zachary A. Silver +6 more
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A mechanistic understanding of allosteric immune escape pathways in the HIV-1 envelope glycoprotein. [PDF]
PLoS Computational Biology, 2013 The HIV-1 envelope (Env) spike, which consists of a compact, heterodimeric trimer of the glycoproteins gp120 and gp41, is the target of neutralizing antibodies. However, the high mutation rate of HIV-1 and plasticity of Env facilitates viral evasion from
Anurag Sethi +4 more
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eLife, 2015 The HIV-1 envelope protein gp120 is both the target of neutralizing antibodies and a major focus of vaccine efforts; however how it is delivered to B cells to elicit an antibody response is unknown.
Chung Park +3 more
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Quantifying Anti-HIV Envelope-Specific Antibodies in Plasma from HIV Infected Individuals
Viruses, 2019 Quantifying HIV Envelope (Env)-specific antibodies in HIV+ plasma is useful for interpreting antibody dependent cellular cytotoxicity assay results. HIV Env, the only viral protein expressed on the surface of infected cells, has a native trimeric closed ...
Sanket Kant +12 more
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The influence of N-linked glycans on the molecular dynamics of the HIV-1 gp120 V3 loop. [PDF]
PLoS ONE, 2013 N-linked glycans attached to specific amino acids of the gp120 envelope trimer of a HIV virion can modulate the binding affinity of gp120 to CD4, influence coreceptor tropism, and play an important role in neutralising antibody responses.
Natasha T Wood +6 more
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Evolution of the HIV-1 envelope glycoproteins with a disulfide bond between gp120 and gp41
Retrovirology, 2004 Background We previously described the construction of an HIV-1 envelope glycoprotein complex (Env) that is stabilized by an engineered intermolecular disulfide bond (SOS) between gp120 and gp41.
Caffrey Michael +5 more
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