Results 41 to 50 of about 15,684 (181)

Surfactant Protein D modulates HIV infection of both T-cells and dendritic cells.

PLoS ONE, 2013
Surfactant Protein D (SP-D) is an oligomerized C-type lectin molecule with immunomodulatory properties and involvement in lung surfactant homeostasis in the respiratory tract.
Jens Madsen, Gaurav D Gaiha, Nades Palaniyar, Tao Dong, Daniel A Mitchell, Howard W Clark   +5 more
doaj   +1 more source

A mechanistic understanding of allosteric immune escape pathways in the HIV-1 envelope glycoprotein. [PDF]

PLoS Computational Biology, 2013
The HIV-1 envelope (Env) spike, which consists of a compact, heterodimeric trimer of the glycoproteins gp120 and gp41, is the target of neutralizing antibodies. However, the high mutation rate of HIV-1 and plasticity of Env facilitates viral evasion from
Anurag Sethi, Jianhui Tian, Cynthia A Derdeyn, Bette Korber, S Gnanakaran   +4 more
doaj   +1 more source

Discovery of 4‐Quinazolinone‐Containing Phenylalanine Derivatives as Potent, Resistant‐Tolerant HIV Capsid Inhibitors

MedComm, Volume 7, Issue 5, May 2026.
Novel phenylalanine derivatives were identified as HIV‐1 capsid inhibitors. IC‐2i showed significant anti‐HIV‐1 activity at picomolar concentrations. ABSTRACT The HIV‐1 capsid (CA) is a validated antiviral target that plays critical roles in both the early and late stages of the viral life cycle.
Xujie Zhang, Lin Sun, Laura Walsham, Yuexi Ma, Dang Ding, Mei Wang, Fabao Zhao, Jian Zhang, Zhao Wang, Shujing Xu, Xiangyi Jiang, Yang Zhou, Erik De Clercq, Christophe Pannecouque, Chin‐Ho Chen, David C. Goldstone, Xinyong Liu, Alexej Dick, Peng Zhan   +18 more
wiley   +1 more source

Transgenic mice expressing HIV-1 envelope protein gp120 in the brain as an animal model in neuroAIDS research [PDF]

Journal of NeuroVirology, 2017
HIV-1 infection causes injury to the central nervous system (CNS) and is often associated with neurocognitive disorders. One model for brain damage seen in AIDS patients is the transgenic (tg) mouse expressing a soluble envelope protein gp120 of HIV-1 LAV in the brain in astrocytes under the control of the promoter of glial fibrillary acidic protein ...
Victoria E. Thaney, Ana B. Sanchez, Jerel A. Fields, Arpi Minassian, Jared W. Young, Ricky Maung, Marcus Kaul   +6 more
openaire   +4 more sources

Human immunodeficiency virus 1 glycoprotein 120 induces endoplasmic reticulum stress in neurons

Cell Death and Disease
People living with Human Immunodeficiency Virus (HIV) (PLWH) may develop HIV-associated neurocognitive disorder (HAND) despite the use of antiretroviral therapy.
Christy Agbey, Lee A. Campbell, Thieu Phan, Gerard Ahern, Italo Mocchetti   +4 more
doaj   +1 more source

Extending the Targets for Coronavirus Antivirals Beyond That of Approved Drugs: Insights From Preclinical Research

Microbial Biotechnology, Volume 19, Issue 5, May 2026.
Chemical structure of RIBOTAC inhibitor with metabolic handle binding as nucleotide analogue to SARS‐CoV‐2 RNA dependent RNA polymerase, its linker and the RNase L recruiter which binds RNase L monomers and mediates their dimerization that actives nuclease activity degrading the viral RNA.
Harald Brüssow
wiley   +1 more source

HIV induces synaptic hyperexcitation via cGMP-dependent protein kinase II activation in the FIV infection model.

PLoS Biology, 2018
Over half of individuals infected with human immunodeficiency virus (HIV) suffer from HIV-associated neurocognitive disorders (HANDs), yet the molecular mechanisms leading to neuronal dysfunction are poorly understood. Feline immunodeficiency virus (FIV)
Keira Sztukowski, Kaila Nip, Paige N Ostwald, Matheus F Sathler, Julianna L Sun, Jiayi Shou, Emily T Jorgensen, Travis E Brown, John H Elder, Craig Miller, Franz Hofmann, Sue VandeWoude, Seonil Kim   +12 more
doaj   +1 more source

Immunogenicity of a polyvalent HIV-1 candidate vaccine based on fourteen wild type gp120 proteins in golden hamsters

BMC Immunology, 2006
Background One of the major obstacles in the design of an effective vaccine against HIV-1 is the hypervariability of the HIV-1 envelope glycoprotein. Most HIV-1 vaccine candidates have utilized envelope glycoprotein from a single virus isolate, but to ...
Ghorbani Masoud, Anderson David E, Azizi Ali, Gee Katrina, Diaz-Mitoma Francisco   +4 more
doaj   +1 more source

Broadly binding and functional antibodies and persisting memory B cells elicited by HIV vaccine PDPHV

npj Vaccines, 2022
Since publishing our original reports on the safety and immunogenicity of a polyvalent DNA prime-protein boost HIV vaccine (PDPHV) which elicited high titer antibody responses with broad specificity, neutralizing activities to multiple HIV-1 subtypes, as
Shixia Wang, Nicole L. Yates, Justin Pollara, Yegor Voronin, Sherry Stanfield-Oakley, Dong Han, Guangnan Hu, Wei Li, Guido Ferrari, Georgia D. Tomaras, Shan Lu   +10 more
doaj   +1 more source

Beyond the Barrier: Epithelial Cells as Immune Sentinels in the Female Genital Tract

American Journal of Reproductive Immunology, Volume 95, Issue 5, May 2026.
ABSTRACT Epithelial cells (ECs) of the female genital tract (FGT) serve as an essential barrier and the first line of defense against sexually transmitted pathogens. Beyond providing a physical barrier, these cells actively contribute to immune responses through pathogen recognition, cytokine release, and modulation of adaptive immune responses ...
Lauren Jirik, Shreya Joshi, Aisha Nazli, Charu Kaushic   +3 more
wiley   +1 more source