Results 41 to 50 of about 5,218,351 (211)

Characterisation of llama antibody fragments able to act as HIV-1 entry inhibitors [PDF]

, 2009
Human immunodeficiency virus type 1 (HIV-1) entry into cells is mediated by the functional envelope spike, which consists of trimers of gp120 bound to gp41.
Forsman, A M M, Forsman, A.M.M.
core  

Estimating the threshold surface density of Gp120-CCR5 complexes necessary for HIV-1 envelope-mediated cell-cell fusion. [PDF]

PLoS ONE, 2011
Reduced expression of CCR5 on target CD4(+) cells lowers their susceptibility to infection by R5-tropic HIV-1, potentially preventing transmission of infection and delaying disease progression.
Shiva Naresh Mulampaka, Narendra M Dixit
doaj   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Contribution of endosomal proteins EHD1 and EHD4 to the HIV‐1 replication cycle

The FEBS Journal, EarlyView.
EHD1 and EHD4, two key trafficking proteins, regulate multiple stages of HIV‐1 infection: In producer cells, they help produce fully infectious virus particles, regulate Envelope protein incorporation in a cell‐type‐dependent manner, and limit the accumulation of antiviral IFITM proteins in virions.
Grégory Pacini, Konstantinos Poalas, Margaux Versapuech, Clarisse Berlioz‐Torrent, Katy Janvier   +4 more
wiley   +1 more source

Role of the transcription factor E2F1 in CXCR4-mediated neurotoxicity and HIV neuropathology

Neurobiology of Disease, 2007
This study sought to determine the role of the transcription factor E2F1 in CXCR4-mediated neurotoxicity and HIV neuropathology. We studied the effect of the HIV envelope protein gp120 on the expression of E2F1-dependent apoptotic proteins in human and ...
Saori Shimizu, Muhammad Z. Khan, Randi L Hippensteel, Anjum Parkar,, Ramesh Raghupathi, Olimpia Meucci   +5 more
doaj   +1 more source

Canonical Antibodies Adopt Distinct Binding Modes to Recognize Viral Glycan Shields

Advanced Science, Volume 13, Issue 61, 3 November 2026.
Canonical Y‐shaped antibodies recognize viral glycan shields through adaptive Fab assembly states shaped by glycan organization and somatic hypermutation. Structural analyses ofbroadly neutralizing antibodies VRC35 and VRC36 across glycoproteins of HIV‐1, influenza, SARS‐CoV‐2, and Lassa viruses reveal distinct Fab assembly states, spanning monovalent,
Jiaxuan Cheng, Evan M. Cale, Amirabbas Maghsoudi, Matthew S. Sutton, Nancy S. Longo, Rebecca A. Gillespie, Lingshu Wang, Ivan Kosik, Sue Chong, Atsuhiro Yasuhara, Tatsiana Bylund, Arne Schön, Prabhanshu Tripathi, Yaroslav Tsybovsky, Haotian Lei, Nicholas C. Morano, Allison B. Lupatkin, Abraham J. Morton, Zabrina C. Lang, Jordan E. Becker, Isabella R. Frascilla, Myungjin Lee, Ning Li, Cuiping Liu, Ryan S. Roark, Chen‐Hsiang Shen, I‐Ting Teng, David J. Van Wazer, Danyi Wang, Lingyuan Wu, Goran Ahlsen, Mike Castro, Haijuan Du, Michael J. Ernandes, Tiansheng Li, Bob C. Lin, Mark K. Louder, Krisha McKee, Jonah S. Merriam, Sijy O'Dell, Li Ou, Sergei Pletnev, David Prikryl, Qi Qiu, Sarah Rubin, Mallika Sastry, Stephen D. Schmidt, Asif Shajahan, Andrea R. Shiakolas, Sanjay Srivatsan, Baoshan Zhang, Qiong Zhou, Mark Connors, Jason G. Gall, Yicheng Guo, Rick K. Huang, Yaoxing Huang, Richard A. Koup, Q. Paula Lei, John R. Mascola, Reda Rawi, Leonid Serebryannyy, Lawrence Shapiro, Zizhang Sheng, David D. Ho, Patrick C. Wilson, Jonathan W. Yewdell, Theodore C. Pierson, Masaru Kanekiyo, Nicole A. Doria‐Rose, Peter D. Kwong, Tongqing Zhou   +71 more
wiley   +1 more source

Structural insights into tyrosine sulfation of CCR5 by human tyrosylprotein sulfotransferase‐1

The FEBS Journal, Volume 293, Issue 21, Page 6552-6568, November 2026.
Post‐translational sulfation of the chemokine receptor CCR5 is involved in crucial biological processes such as viral infection and chemokine signaling. This sulfation is catalyzed by human tyrosylprotein sulfotransferases (hTPSTs) within the Golgi lumen. However, the detailed molecular mechanism remains unresolved.
Shinnosuke Tanaka, Hirai Asano, Kota Toyoda, Toshiaki Nishiyori, Hidetaka Kojo, Kazuto Kiyomatsu, Katsuhisa Kurogi, Yoichi Sakakibara, Etsuko Nishimoto, Takamasa Teramoto, Yoshimitsu Kakuta   +10 more
wiley   +1 more source

Harnessing Extracellular Vesicles for Precision Diagnostics and Infectious Disease Management: Integrating Host‐ and Pathogen‐Derived Cues

Exploration, Volume 6, Issue 5, October 2026.
This review summarizes the diagnostic and monitoring potential of host‐pathogen extracellular vesicles (hpEVs) in infectious diseases, advances in their isolation and analysis, and challenges to clinical translation. ABSTRACT Conventional infectious disease diagnostics often rely on detecting pathogen‐derived factors or an immune response directed ...
Ming Zhou, Yongchun Pan, Bo Ning, Christopher J. Lyon, Yang Liu, Tony Hu   +5 more
wiley   +1 more source

HIV-1 gp120 protein downregulates Nef induced IL-6 release in immature dentritic cells through interplay of DC-SIGN.

PLoS ONE, 2013
HIV-1 replication is a tightly controlled mechanism which demands the interplay of host as well as viral factors. Both gp120 (envelope glycoprotein) and Nef (regulatory protein) have been correlated with the development of AIDS disease in independent ...
Roni Sarkar, Debashis Mitra, Sekhar Chakrabarti   +2 more
doaj   +1 more source

HIV‐1 Envelope Protein gp120 Is Present at High Concentrations in Secondary Lymphoid Organs of Individuals with Chronic HIV‐1 Infection [PDF]

The Journal of Infectious Diseases, 2009
The envelope protein of human immunodeficiency virus type 1 (HIV-1)--glycoprotein 120 (gp120)--has been demonstrated to dysregulate T cell function in vitro. We obtained autopsy tissues from individuals with chronic HIV-1 infection to determine whether there was enough gp120 in lymphoid tissues and/or blood to elicit these effects.
Santosuosso M, Righi E, Lindstrom V, Leblanc PR, Poznansky MC   +4 more
openaire   +3 more sources