Results 41 to 50 of about 15,690 (179)

The V2 domain of HIV gp120 mimics an interaction between CD4 and integrin ⍺4β7.

PLoS Pathogens, 2023
The CD4 receptor, by stabilizing TCR-MHC II interactions, plays a central role in adaptive immunity. It also serves as the HIV docking receptor. The HIV gp120 envelope protein binds directly to CD4.
Donald Van Ryk, Sinmanus Vimonpatranon, Joe Hiatt, Sundar Ganesan, Nathalie Chen, Jordan McMurry, Saadiq Garba, Susie Min, Livia R Goes, Alexandre Girard, Jason Yolitz, Isabella Licavoli, Danlan Wei, Dawei Huang, Marcelo A Soares, Elena Martinelli, Claudia Cicala, James Arthos   +17 more
doaj   +1 more source

Contribution of endosomal proteins EHD1 and EHD4 to the HIV‐1 replication cycle

The FEBS Journal, EarlyView.
EHD1 and EHD4, two key trafficking proteins, regulate multiple stages of HIV‐1 infection: In producer cells, they help produce fully infectious virus particles, regulate Envelope protein incorporation in a cell‐type‐dependent manner, and limit the accumulation of antiviral IFITM proteins in virions.
Grégory Pacini, Konstantinos Poalas, Margaux Versapuech, Clarisse Berlioz‐Torrent, Katy Janvier   +4 more
wiley   +1 more source

Specific binding of HIV-1 envelope protein gp120 to the structural membrane proteins ezrin and moesin

Virus Research, 1997
The observation that HIV in vitro can infect CD4- and Gal-C-negative brain cell lines has stimulated this study to identify alternative gp120-binding proteins on brain cells. HIV-1 gp120 binding proteins of the CD4-negative and Gal-C-negative, non-productively infectable human glioblastoma cell line D54 were purified by affinity chromatography over a ...
Hecker, Claudia, Weise, Christoph, Schneider-Schaulies, Jürgen, Holmes, Harvey C, ter Meulen, Volker   +4 more
openaire   +2 more sources

Living Microbial Drugs

Chemistry – A European Journal, Volume 32, Issue 26, 11 July 2026.
The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik, Nazlıcan Tunç, Senem Şen, Urartu Özgür Şafak Şeker   +3 more
wiley   +1 more source

Adaptation of the REINVENT neural network architecture to generate potential HIV-1 entry inhibitors

Informatika
Objectives. The main purpose of this work is to adapt the architecture of the REINVENT neural network to generate potential inhibitors of the HIV-1 envelope protein gp120 using in the learning process with reinforcement of molecular docking on GPUs ...
D. A. Varabyeu, A. D. Karpenko, A. V. Tuzikov, A. M. Andrianov   +3 more
doaj   +1 more source

Slit2/Robo4 signaling modulates HIV-1 gp120-induced lymphatic hyperpermeability.

PLoS Pathogens, 2012
Dissemination of HIV in the host involves transit of the virus and virus-infected cells across the lymphatic endothelium. HIV may alter lymphatic endothelial permeability to foster dissemination, but the mechanism is largely unexplored.
Xuefeng Zhang, Jinlong Yu, Paula M Kuzontkoski, Weiquan Zhu, Dean Y Li, Jerome E Groopman   +5 more
doaj   +1 more source

In Silico Identification of Novel Aromatic Compounds as Potential HIV-1 Entry Inhibitors Mimicking Cellular Receptor CD4

Viruses, 2019
Despite recent progress in the development of novel potent HIV-1 entry/fusion inhibitors, there are currently no licensed antiviral drugs based on inhibiting the critical interactions of the HIV-1 envelope gp120 protein with cellular receptor CD4.
Alexander M. Andrianov, Grigory I. Nikolaev, Yuri V. Kornoushenko, Wei Xu, Shibo Jiang, Alexander V. Tuzikov   +5 more
doaj   +1 more source

Functional Mimetics of the HIV-1 CCR5 Co-Receptor Displayed on the Surface of Magnetic Liposomes. [PDF]

PLoS ONE, 2015
Chemokine G protein coupled receptors, principally CCR5 or CXCR4, function as co-receptors for HIV-1 entry into CD4+ T cells. Initial binding of the viral envelope glycoprotein (Env) gp120 subunit to the host CD4 receptor induces a cascade of structural ...
Alona Kuzmina, Karin Vaknin, Garik Gdalevsky, Maria Vyazmensky, Robert S Marks, Ran Taube, Stanislav Engel   +6 more
doaj   +1 more source

Full‐Length Next‐Generation Sequencing of 11 HLA Loci of More Than 1000 Individuals From Clinical Cohorts in East and West Africa

HLA, Volume 108, Issue 1, July 2026.
ABSTRACT HLA loci have been implicated in several diseases, including HIV‐1, from different world populations. It is necessary to characterise HLA allele variation at the population level prior to investigating associations linked to human diseases. In global databases, limited high‐resolution HLA allele types generated by next‐generation sequencing ...
Yvonne V. Rosario, Aviva Geretz, Lakshmi Rani Iyer, Philip K. Ehrenberg, Alýa Tyson, Hannah Kibuuka, Fred Wabwire‐Mangen, Lucas Maganga, Abdulwasiu Tiamiyu, Jonah Maswai, Josphat Kosgei, Frederick Sawe, Gary R. Matyas, Merlin L. Robb, Julie A. Ake, Rasmi Thomas   +15 more
wiley   +1 more source

HIV‐1 Envelope Protein gp120 Is Present at High Concentrations in Secondary Lymphoid Organs of Individuals with Chronic HIV‐1 Infection [PDF]

The Journal of Infectious Diseases, 2009
The envelope protein of human immunodeficiency virus type 1 (HIV-1)--glycoprotein 120 (gp120)--has been demonstrated to dysregulate T cell function in vitro. We obtained autopsy tissues from individuals with chronic HIV-1 infection to determine whether there was enough gp120 in lymphoid tissues and/or blood to elicit these effects.
Santosuosso M, Righi E, Lindstrom V, Leblanc PR, Poznansky MC   +4 more
openaire   +3 more sources