Development of an Ultrasensitive ELISA Assay for Evaluating HIV-1 Envelope Glycoprotein as a Marker for Targeted Activator of Cell Kill [PDF]
VirusesThe HIV-1 envelope glycoprotein gp120 is prominently exposed on the surface of both HIV-1 virions and infected host cells, serving as a key marker of infection.
Guoxin Wu +11 more
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Highly efficient production of HIV-1AD8 gp120 in mammalian cells [PDF]
Journal of VirologyHuman immunodeficiency virus type 1 (HIV-1) envelope glycoproteins (Envs) interact with the CD4 receptor and CCR5/CXCR4 coreceptor expressed on target cells to mediate viral entry. Infection is initiated when the HIV-1 gp120 subunit of Envs binds to host
Tanvi Mathur +3 more
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Human immunodeficiency virus 1 glycoprotein 120 induces endoplasmic reticulum stress in neurons [PDF]
Cell Death and DiseasePeople living with Human Immunodeficiency Virus (HIV) (PLWH) may develop HIV-associated neurocognitive disorder (HAND) despite the use of antiretroviral therapy.
Christy Agbey +4 more
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Structure, 2008 NBD-556 is a class of HIV-1 entry inhibitors that binds HIV-1 surface glycoprotein gp120 and induces conformational changes, which mimic those caused by CD4 binding. Here, Madani et al. (2008) show that NBD-556 binds to the highly conserved "Phe-43 cavity" on gp120.
Repik, Alexander, Clapham, Paul R.
openaire +4 more sources
Insight derived from molecular dynamics simulations into molecular motions, thermodynamics and kinetics of HIV-1 gp120. [PDF]
PLoS ONE, 2014 Although the crystal structures of the HIV-1 gp120 core bound and pre-bound by CD4 are known, the details of dynamics involved in conformational equilibrium and transition in relation to gp120 function have remained elusive.
Peng Sang +4 more
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HIV-1 gp120 induces expression of IL-6 through a nuclear factor-kappa B-dependent mechanism: suppression by gp120 specific small interfering RNA. [PDF]
PLoS ONE, 2011 In addition to its role in virus entry, HIV-1 gp120 has also been implicated in HIV-associated neurocognitive disorders. However, the mechanism(s) responsible for gp120-mediated neuroinflammation remain undefined.
Ankit Shah +11 more
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The glycan shield of HIV is predominantly oligomannose independently of production system or viral clade. [PDF]
PLoS ONE, 2011 The N-linked oligomannose glycans of HIV gp120 are a target for both microbicide and vaccine design. The extent of cross-clade conservation of HIV oligomannose glycans is therefore a critical consideration for the development of HIV prophylaxes.
Camille Bonomelli +7 more
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Viruses, 2023 Despite the benefits of combinatorial antiretroviral therapies (cART), virotoxic HIV proteins are still detectable within the central nervous system. Approximately half of all cART-treated patients contend with neurological impairments.
Emaya M. Moss +3 more
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A strategy for eliciting antibodies against cryptic, conserved, conformationally dependent epitopes of HIV envelope glycoprotein. [PDF]
PLoS ONE, 2010 Novel strategies are needed for the elicitation of broadly neutralizing antibodies to the HIV envelope glycoprotein, gp120. Experimental evidence suggests that combinations of antibodies that are broadly neutralizing in vitro may protect against ...
Hanna C Kelker +2 more
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Synergistic cooperation between methamphetamine and HIV-1 gsp120 through the P13K/Akt pathway induces IL-6 but not IL-8 expression in astrocytes. [PDF]
PLoS ONE, 2012 HIV-1 envelope protein gp120 has been extensively studied for neurotoxic effects that have been attributed to the increased expression of various proinflammatory cytokines in the CNS.
Ankit Shah +4 more
doaj +1 more source