Results 41 to 50 of about 34,750 (223)
Shaping T cell - B cell collaboration in the response to human immunodeficiency virus type 1 envelope glycoprotein gp120 by peptide priming. [PDF]
PLoS ONE, 2013 Prime-boost vaccination regimes have shown promise for obtaining protective immunity to HIV. Poorly understood mechanisms of cellular immunity could be responsible for improved humoral responses. Although CD4+ T-cell help promotes B-cell development, the
N Kalaya Steede +5 more
doaj +1 more source
Mass Spectrometry Reviews, EarlyView.ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley +1 more source
NBD analogue binding to gp120 enhances 17b-gp120 interaction.
, 2014 (A–D) 100 nM of gp120 coremin or full-length gp120 in the presence of 0–100 µM of NBD analogues was passed over 17b antibody immobilized on a CM5 chip. The binding of gp120 to 17b increased, in a concentration dependent manner, in response to treatment ...
Judith M. LaLonde (515827) +9 more
core +1 more source
Frontiers in Cellular Neuroscience, 2019 Activation of the p75 neurotrophin receptor (p75NTR), by the proneurotrophin brain-derived neurotrophic factor (proBDNF), triggers loss of synapses and promotes neuronal death.
Andrew Speidell +5 more
doaj +1 more source
Cancer pain: current practice and emerging targets
British Journal of Pharmacology, EarlyView.Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye +5 more
wiley +1 more source
, 2015 Representative binding curves of different HIV-1 proteins with a panel of well-known neutralizing Abs, such as quaternary conformation dependent antibodies PG9 (A) and PG16 (B); bnAbs targeting the CD4 binding site b12 (C) and VRC01 (D); the glycan ...
César Santiago (146919) +8 more
core +1 more source
VirusesThe HIV-1 envelope glycoprotein gp120 is prominently exposed on the surface of both HIV-1 virions and infected host cells, serving as a key marker of infection.
Guoxin Wu +11 more
doaj +1 more source
Crystal structure of the neutralizing Llama V(HH) D7 and its mode of HIV-1 gp120 interaction.
PLoS ONE, 2010 HIV-1 entry into host cells is mediated by the sequential binding of the envelope glycoprotein gp120 to CD4 and a chemokine receptor. Antibodies binding to epitopes overlapping the CD4-binding site on gp120 are potent inhibitors of HIV entry, such as the
Andreas Hinz +9 more
doaj +1 more source
Peripheral targets for neuropathic pain
British Journal of Pharmacology, EarlyView.Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour +3 more
wiley +1 more source
Lithium ameliorates HIV-gp120-mediated neurotoxicity
, 2002 To investigate the protective effects of lithium against HIV-gp120-mediated toxicity in vivo, mice were exposed to lithium and gp120 and levels of the neuronal markers, microtubule-associated protein-2 and NeuN, and the astrocyte marker, glial fibrillary
Bell, C +6 more
core +1 more source