Results 51 to 60 of about 24,116 (179)

The Inflammatory, Apoptotic, and Cardiovascular Role of Soluble and Tissue Gp120 in PLWH on Antiretroviral Therapy: Is Anti-gp120 Therapy Needed?

Acta Microbiologica Hellenica
People living with HIV (PLWH) receiving effective antiretroviral therapy (ART) continue to exhibit chronic immune activation and systemic inflammation despite virological suppression.
Alessia Mirabile, Dalida Bivona, Giuseppe Nicolò Conti, Andrea Marino, Benedetto Maurizio Celesia, Grazia Scuderi, Paolo Fagone, Serena Matera, Serena Spampinato, Giuseppe Nunnari   +9 more
doaj   +1 more source

Immunogenicity of the outer domain of a HIV-1 clade C gp120

Retrovirology, 2007
Background The possibility that a sub domain of a C clade HIV-1 gp120 could act as an effective immunogen was investigated. To do this, the outer domain (OD) of gp120CN54 was expressed and characterized in a construct marked by a re-introduced ...
Xu Xiaodong, Chen Hongying, Jones Ian M
doaj   +1 more source

The Impact of Surfactant Protein‐D Gene Polymorphism on COVID‐19 Clinical Outcomes

Immunity, Inflammation and Disease, Volume 14, Issue 5, May 2026.
ABSTRACT Background COVID‐19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), presents a broad spectrum of clinical manifestations, ranging from asymptomatic cases to severe, life‐threatening respiratory complications. Pulmonary surfactant‐associated protein D (SP‐D) is a critical component of pulmonary immune defense.
Nadia Nasirzadeh Kolsari, Azarakhsh Azaran, Roya Pirmoradi, Maryam Moradi, Roohangiz Nashibi, Shahram Jalilian   +5 more
wiley   +1 more source

Shaping T cell - B cell collaboration in the response to human immunodeficiency virus type 1 envelope glycoprotein gp120 by peptide priming. [PDF]

PLoS ONE, 2013
Prime-boost vaccination regimes have shown promise for obtaining protective immunity to HIV. Poorly understood mechanisms of cellular immunity could be responsible for improved humoral responses. Although CD4+ T-cell help promotes B-cell development, the
N Kalaya Steede, Blake J Rust, Mohammad M Hossain, Lucy C Freytag, James E Robinson, Samuel J Landry   +5 more
doaj   +1 more source

Discovery of 4‐Quinazolinone‐Containing Phenylalanine Derivatives as Potent, Resistant‐Tolerant HIV Capsid Inhibitors

MedComm, Volume 7, Issue 5, May 2026.
Novel phenylalanine derivatives were identified as HIV‐1 capsid inhibitors. IC‐2i showed significant anti‐HIV‐1 activity at picomolar concentrations. ABSTRACT The HIV‐1 capsid (CA) is a validated antiviral target that plays critical roles in both the early and late stages of the viral life cycle.
Xujie Zhang, Lin Sun, Laura Walsham, Yuexi Ma, Dang Ding, Mei Wang, Fabao Zhao, Jian Zhang, Zhao Wang, Shujing Xu, Xiangyi Jiang, Yang Zhou, Erik De Clercq, Christophe Pannecouque, Chin‐Ho Chen, David C. Goldstone, Xinyong Liu, Alexej Dick, Peng Zhan   +18 more
wiley   +1 more source

Extending the Targets for Coronavirus Antivirals Beyond That of Approved Drugs: Insights From Preclinical Research

Microbial Biotechnology, Volume 19, Issue 5, May 2026.
Chemical structure of RIBOTAC inhibitor with metabolic handle binding as nucleotide analogue to SARS‐CoV‐2 RNA dependent RNA polymerase, its linker and the RNase L recruiter which binds RNase L monomers and mediates their dimerization that actives nuclease activity degrading the viral RNA.
Harald Brüssow
wiley   +1 more source

Signal peptide exchange alters HIV-1 envelope antigenicity and immunogenicity

Frontiers in Immunology
IntroductionHIV-1 envelope (Env) is the key target for antibodies (Abs) against the virus and thus an important HIV-1 vaccine component. Env is synthesized from a gp160 precursor with a signal peptide (SP) at its N-terminus.
Chitra Upadhyay, Priyanka Rao, Mohammad Amin Behzadi, Roya Feyznezhad, Gregory S. Lambert, Rajnish Kumar, Madhu Kumar, Weiming Yang, Xunqing Jiang, Christina C. Luo, Arthur Nadas, James Arthos, Xiang-Peng Kong, Hui Zhang, Catarina E. Hioe, Catarina E. Hioe, J. Andrew Duty   +16 more
doaj   +1 more source

Beyond the Barrier: Epithelial Cells as Immune Sentinels in the Female Genital Tract

American Journal of Reproductive Immunology, Volume 95, Issue 5, May 2026.
ABSTRACT Epithelial cells (ECs) of the female genital tract (FGT) serve as an essential barrier and the first line of defense against sexually transmitted pathogens. Beyond providing a physical barrier, these cells actively contribute to immune responses through pathogen recognition, cytokine release, and modulation of adaptive immune responses ...
Lauren Jirik, Shreya Joshi, Aisha Nazli, Charu Kaushic   +3 more
wiley   +1 more source

Membrane Vesicles from Lacticaseibacillus Casei BL23 Exhibit Antimicrobial Activity Against Escherichia coli and Immunostimulatory Effects on Human Peripheral Blood Mononuclear Cells

Advanced Healthcare Materials, Volume 15, Issue 16, 24 April 2026.
Membrane vesicles derived from the probiotic Lacticaseibacillus casei BL23 demonstrate antimicrobial properties against Escherichia coli and a potential biological effect in improving the overall survival of C. elegans infected with Pseudomonas aeruginosa. These vesicles stimulated immune responses in primary cells without causing toxicity. Our results
Cecilia L. D'Antoni, Leila Pourtalebi Jahromi, Lorenzo Sana, Ana Paula Domínguez Rubio, Maja Dorfner, Jennifer Munkert, Heike Danzer, Philipp Arnold, Mikhail Lebedev, Esther Zanin, Oscar E. Pérez, Gregor Fuhrmann   +11 more
wiley   +1 more source

Comprehensive Characterization of Reference Standard Lots of HIV-1 Subtype C Gp120 Proteins for Clinical Trials in Southern African Regions

Vaccines, 2016
Two HIV-1 subtype C gp120 protein candidates were the selected antigens for several experimental vaccine regimens now under evaluation in HVTN 100 Phase I/II clinical trial aiming to support the start of the HVTN 702 Phase IIb/III trial in southern ...
Zihao Wang, Clarisse Lorin, Marguerite Koutsoukos, David Franco, Babak Bayat, Ying Zhang, Andrea Carfi, Susan W. Barnett, Frederick Porter   +8 more
doaj   +1 more source