Results 61 to 70 of about 46,924 (216)
Frontiers in Cellular Neuroscience, 2019 Activation of the p75 neurotrophin receptor (p75NTR), by the proneurotrophin brain-derived neurotrophic factor (proBDNF), triggers loss of synapses and promotes neuronal death.
Andrew Speidell +5 more
doaj +1 more source
PLoS MedicineBackgroundAdjuvants are widely used to enhance and/or direct vaccine-induced immune responses yet rarely evaluated head-to-head. Our trial directly compared immune responses elicited by MF59 versus alum adjuvants in the RV144-like HIV vaccine regimen ...
Zoe Moodie +33 more
doaj +1 more source
Preliminary evaluation of KYNA ameliorates neuronal pyroptosis induced by HIV-1 gp120
International Journal of Infectious DiseasesBackgrounds: HIV-associated neurocognitive disorders (HAND) are the common complications in the central nervous system (CNS), mainly causing HIV dementia and leading to serious social economic load.
Dr Xuefeng Gao +5 more
doaj +1 more source
Crystal structure of the neutralizing Llama V(HH) D7 and its mode of HIV-1 gp120 interaction.
PLoS ONE, 2010 HIV-1 entry into host cells is mediated by the sequential binding of the envelope glycoprotein gp120 to CD4 and a chemokine receptor. Antibodies binding to epitopes overlapping the CD4-binding site on gp120 are potent inhibitors of HIV entry, such as the
Andreas Hinz +9 more
doaj +1 more source
Malang Neurology Journal, 2021 Background: Neuro-inflammation plays a role in the pathogenesis of HIV-associated dementia (HIV). Activation of microglia is essential for triggering inflammatory-mediated neurotoxicity.
Masruroh Rahayu +3 more
doaj +1 more source
Phage display selection of HIV specific conserved mimotopes with IgG from long-term non-progressors [PDF]
, 2005 Poster presentation Background The aim of this study is to identify conserved epitopes of HIV-1 neutralizing antibodies in polyclonal plasma from LTNP to finally derive vaccine candidates.
Antoni, Sascha +6 more
core +1 more source
A Review on Medicinal Chemistry and Biological Activity of Dihydropyrimidinones Against HIV
Archiv der Pharmazie, Volume 359, Issue 4, April 2026.This article presents the latest advances in the development of dihydropyrimidinone (DHPM) derivatives as promising candidates against HIV. By exploring their interactions with essential viral targets and highlighting innovative compounds with potent antiviral activity, we provide an updated perspective on the opportunities for new antiretroviral ...
Debora I. Leite +11 more
wiley +1 more source
HemaSphere, Volume 10, Issue 4, April 2026.Abstract Multiple myeloma (MM) cells interact with different components of the bone marrow (BM) microenvironment, which plays a critical role in MM progression and confers resistance to therapy. Here, we report that monocytes actively control MM cell metabolism by transferring mitochondria to MM cells, thereby increasing their mitochondrial content ...
Ramin Raoof +18 more
wiley +1 more source
The essential role of mitochondrial dynamics in antiviral immunity. [PDF]
, 2018 Viruses alter cellular physiology and function to establish cellular environment conducive for viral proliferation. Viral immune evasion is an essential aspect of viral persistence and proliferation.
Ahn, Dae-Gyun +3 more
core +2 more sources
Acta Microbiologica HellenicaPeople living with HIV (PLWH) receiving effective antiretroviral therapy (ART) continue to exhibit chronic immune activation and systemic inflammation despite virological suppression.
Alessia Mirabile +9 more
doaj +1 more source