Results 61 to 70 of about 34,750 (223)

Immunogenicity of the outer domain of a HIV-1 clade C gp120

Retrovirology, 2007
Background The possibility that a sub domain of a C clade HIV-1 gp120 could act as an effective immunogen was investigated. To do this, the outer domain (OD) of gp120CN54 was expressed and characterized in a construct marked by a re-introduced ...
Xu Xiaodong, Chen Hongying, Jones Ian M
doaj   +1 more source

Crystal structures of HIV-1 gp120 envelope glycoprotein in complex with NBD analogues that target the CD4-binding site. [PDF]

PLoS ONE, 2014
Efforts to develop therapeutic agents that inhibit HIV-1 entry have led to the identification of several small molecule leads. One of the most promising is the NBD series, which binds within a conserved gp120 cavity and possesses para-halogen substituted
Young Do Kwon, Judith M LaLonde, Yongping Yang, Mark A Elban, Akihiro Sugawara, Joel R Courter, David M Jones, Amos B Smith, Asim K Debnath, Peter D Kwong   +9 more
doaj   +1 more source

Binding of HIV‐1 gp120 to the nicotinic receptor [PDF]

FEBS Letters, 1992
We previously described a significant sequence homology between HIV‐1 gp120 and the functional sites responsible for the specific binding of snake curare‐mimetic neurotoxins and rabies virus glycoprotein to the nicotinic acetylcholine receptor. Here we report findings about the existence of a mechanism of functional molecular mimicry which could enable
Bracci, Luisa, Lozzi, Luisa, Rustici, Mauro, Neri, Paolo   +3 more
openaire   +4 more sources

Structural insights into tyrosine sulfation of CCR5 by human tyrosylprotein sulfotransferase‐1

The FEBS Journal, Volume 293, Issue 21, Page 6552-6568, November 2026.
Post‐translational sulfation of the chemokine receptor CCR5 is involved in crucial biological processes such as viral infection and chemokine signaling. This sulfation is catalyzed by human tyrosylprotein sulfotransferases (hTPSTs) within the Golgi lumen. However, the detailed molecular mechanism remains unresolved.
Shinnosuke Tanaka, Hirai Asano, Kota Toyoda, Toshiaki Nishiyori, Hidetaka Kojo, Kazuto Kiyomatsu, Katsuhisa Kurogi, Yoichi Sakakibara, Etsuko Nishimoto, Takamasa Teramoto, Yoshimitsu Kakuta   +10 more
wiley   +1 more source

Brain-Derived Neurotrophic Factor Inhibits Human Immunodeficiency Virus-1/gp120-Mediated Cerebellar Granule Cell Death by Preventing gp120 Internalization

, 2003
The human immunodeficiency virus type 1 (HIV-1) envelope protein gp120 has been implicated in the pathogenesis of HIV-1 dementia. Thus, inhibition of gp120 activity could reduce HIV toxicity in the brain.
Italo Mocchetti, Alessia Bachis, Eugene O. Major   +2 more
core   +1 more source

Real‐world use and effectiveness of fostemsavir in a US clinical setting: Insights from Trio Health HIV Research Network

HIV Medicine, Volume 27, Issue 11, Page 1814-1822, November 2026.
Abstract Objective To describe real‐world patterns of use, virologic and immunologic outcomes and treatment persistence among people with HIV (PWH) initiating fostemsavir (FTR) in a diverse US cohort. Design Retrospective cohort study of adults receiving FTR in clinical practice, stratified by baseline viral suppression status.
Richard Elion, Cassidy Henegar, Isobel McEwen, Andrew Frick, Moti Ramgopal, Steven Santiago, Karam Mounzer, Gregory Huhn, Charles Walworth, Leigh Ragone, Vani Vannappagari   +10 more
wiley   +1 more source

Hinge sites of gp120 based on gp120 ternary complex ENM calculation.

, 2012
Hinge sites of gp120 based on gp120 ternary complex ENM calculation.
Wayne A. Hendrickson (107966), Anil Korkut (107963)   +1 more
core   +1 more source

The Inflammatory, Apoptotic, and Cardiovascular Role of Soluble and Tissue Gp120 in PLWH on Antiretroviral Therapy: Is Anti-gp120 Therapy Needed?

Acta Microbiologica Hellenica
People living with HIV (PLWH) receiving effective antiretroviral therapy (ART) continue to exhibit chronic immune activation and systemic inflammation despite virological suppression.
Alessia Mirabile, Dalida Bivona, Giuseppe Nicolò Conti, Andrea Marino, Benedetto Maurizio Celesia, Grazia Scuderi, Paolo Fagone, Serena Matera, Serena Spampinato, Giuseppe Nunnari   +9 more
doaj   +1 more source

Harnessing Extracellular Vesicles for Precision Diagnostics and Infectious Disease Management: Integrating Host‐ and Pathogen‐Derived Cues

Exploration, Volume 6, Issue 5, October 2026.
This review summarizes the diagnostic and monitoring potential of host‐pathogen extracellular vesicles (hpEVs) in infectious diseases, advances in their isolation and analysis, and challenges to clinical translation. ABSTRACT Conventional infectious disease diagnostics often rely on detecting pathogen‐derived factors or an immune response directed ...
Ming Zhou, Yongchun Pan, Bo Ning, Christopher J. Lyon, Yang Liu, Tony Hu   +5 more
wiley   +1 more source

The Lord of the Rings: Cysteine bonds crosslink the tail of siphovirus

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Long, non‐contractile tails composed of helical hexameric protein repeats that assemble into continuous tubular structures characterize siphoviruses. The siphovirus tail tube protein gp39 contains two cysteine residues per monomer. Cryo‐electron microscopy revealed that these cysteines are oriented toward the interface between the rings, which
Simona Povilonienė, Giedrius Sasnauskas, Giedrė Tamulaitienė, Greta Labutytė, Martynas Talaikis, Algirdas Mikšys, Aurelija Zajančkauskaitė, Lidija Truncaitė, Rolandas Meškys, Vida Časaitė   +9 more
wiley   +1 more source