Results 61 to 70 of about 24,116 (179)

A Review on Medicinal Chemistry and Biological Activity of Dihydropyrimidinones Against HIV

Archiv der Pharmazie, Volume 359, Issue 4, April 2026.
This article presents the latest advances in the development of dihydropyrimidinone (DHPM) derivatives as promising candidates against HIV. By exploring their interactions with essential viral targets and highlighting innovative compounds with potent antiviral activity, we provide an updated perspective on the opportunities for new antiretroviral ...
Debora I. Leite, Fernando B. Macedo, Murilo Marinho de C. Lima, Isabelle S. Brum, Jonathan Fragoso Miranda de Oliveira, Ana Clara S. Costa, Stella C. Duarte, Sarah Moon, Stefany de Castro B. Moura, Andressa P. de Oliveira, Nubia Boechat, Monica M. Bastos   +11 more
wiley   +1 more source

Involvement of metabotropic glutamate receptor 5, AKT/PI3K Signaling and NF-κB pathway in methamphetamine-mediated increase in IL-6 and IL-8 expression in astrocytes

Journal of Neuroinflammation, 2012
Methamphetamine (MA) is one of the commonly used illicit drugs and the central nervous system toxicity of MA is well documented. The mechanisms contributing to this toxicity have not been fully elucidated.
Shah Ankit, Silverstein Peter S, Singh Dhirendra P, Kumar Anil   +3 more
doaj   +1 more source

Monocyte‐mediated metabolic rewiring via CD31‐CD38 interactions promotes growth and drug‐resistance in multiple myeloma

HemaSphere, Volume 10, Issue 4, April 2026.
Abstract Multiple myeloma (MM) cells interact with different components of the bone marrow (BM) microenvironment, which plays a critical role in MM progression and confers resistance to therapy. Here, we report that monocytes actively control MM cell metabolism by transferring mitochondria to MM cells, thereby increasing their mitochondrial content ...
Ramin Raoof, Giada Dal Collo, Helga Simon‐Molas, Panagiota Tzortzi, Konxhe Kulaj, Elif N. Demirez, Crescenzo Massaro, Renée Poels, Charlotte L. B. M. Korst, Chloe A. O'Neill, Wassilis S. C. Bruins, Marloes E. C. Broekmans, Payam Behradkia, Maria Krevvata, Sonja Zweegman, Arnon P. Kater, Serena R. Baglio, Tuna Mutis, Niels W. C. J. van de Donk   +18 more
wiley   +1 more source

Mimicking protein-protein interactions through peptide-peptide interactions: HIV-1 gp120 and CXCR4

Frontiers in Immunology, 2013
We have recently designed a soluble synthetic peptide that functionally mimics the HIV-1 coreceptor CXCR4, which is a chemokine receptor that belongs to the family of seven-transmembrane GPCRs.
Andrea eGross, Kalle eMöbius, Christina eHaußner, Norbert eDonhauser, Barbara eSchmidt, Jutta eEichler   +5 more
doaj   +1 more source

HIV‐Associated Pulmonary Arterial Hypertension in Resource‐Limited Settings: A “Forgotten” Diagnosis, a Great Imitator, and a Multi‐Hit Pulmonary Vasculopathy

Pulmonary Circulation, Volume 16, Issue 2, June 2026.
ABSTRACT HIV‐associated pulmonary arterial hypertension (HIV‐PAH) remains one of the most consequential cardiopulmonary complications in people living with HIV (PLWH), persisting despite expanded antiretroviral therapy (ART) coverage. Although contemporary hemodynamic criteria define pulmonary hypertension (PH) as mean pulmonary arterial pressure (mPAP)
Emmanuel Eroume A Egom, Mfopa Adamou, Ibrahima Djouldé, Njimona Ibrahim, Mountchissi Célestin, Lum Abenwi Ambe, Medou Mba Fabrice, Moustapha, René Kamgang   +8 more
wiley   +1 more source

Use of silver nanoparticles increased inhibition of cell-associated HIV-1 infection by neutralizing antibodies developed against HIV-1 envelope proteins

Journal of Nanobiotechnology, 2011
Background HIV/AIDS pandemic is a worldwide public health issue. There is a need for new approaches to develop new antiviral compounds or other therapeutic strategies to limit viral transmission.
Garza Treviño Elsa N, Ixtepan-Turrent Liliana, Lara Humberto H, Singh Dinesh K   +3 more
doaj   +1 more source

HIV-1 gp41-targeting fusion inhibitory peptides enhance the gp120-targeting protein-mediated inactivation of HIV-1 virions

Emerging Microbes and Infections, 2017
Protein- or peptide-based viral inactivators are being developed as novel antiviral drugs with improved efficacy, pharmacokinetics and toxicity profiles because they actively inactivate cell-free human immunodeficiency virus type 1 (HIV-1) virions before
Qianqian Qi, Qian Wang, Weizao Chen, Lanying Du, Dimiter S Dimitrov, Lu Lu, Shibo Jiang   +6 more
doaj   +1 more source

How Vaccinating People Living With HIV May Guide bNAb‑Based Vaccines

Journal of the International AIDS Society, Volume 29, Issue 5, May 2026.
Penny L. Moore, Leonidas Stamatatos, Alexandra Trkola   +2 more
wiley   +1 more source

HIV-1 gp120 Promotes Lysosomal Exocytosis in Human Schwann Cells

Frontiers in Cellular Neuroscience, 2019
Human immunodeficiency virus type 1 (HIV-1) associated neuropathy is the most common neurological complication of HIV-1, with debilitating pain affecting the quality of life.
Gaurav Datta, Nicole M. Miller, Zahra Afghah, Jonathan D. Geiger, Xuesong Chen   +4 more
doaj   +1 more source

Antibodies to the CD4-binding site of HIV-1 gp120 suppress gp120-specific CD4 T cell response while enhancing antibody response

Infectious Agents and Cancer, 2008
Background The binding of Abs to the CD4-binding site (CD4bs) of HIV-1 envelope gp120 has been shown to obstruct the processing and generation of helper epitopes from this antigen, resulting in poor presentation of various gp120 epitopes by MHC class II ...
Hioe Catarina E, Chen Pei-de, Tuen Michael, Visciano Maria   +3 more
doaj   +1 more source