Results 71 to 80 of about 34,750 (223)

Effect of HIV gp120 on MMP production.

, 2013
(a) Effect of increasing concentrations of HIV gp120 on mRNA expression of MMP-9 and MMP-2 in Vk2/E6E7 cells. (b) Effect of increasing concentrations of HIV gp120 on MMP-9 and MMP-2 activity.
Deepak N. Modi (336287), Jyotsna S. Gokral (338837), Atmaram H. Bandivdekar (338839), Sashaina E. Fanibunda (338835)   +3 more
core   +1 more source

Molecular recognition of CCR5 by an HIV-1 gp120 V3 loop.

PLoS ONE, 2014
The binding of protein HIV-1 gp120 to coreceptors CCR5 or CXCR4 is a key step of the HIV-1 entry to the host cell, and is predominantly mediated through the V3 loop fragment of HIV-1 gp120.
Phanourios Tamamis, Christodoulos A Floudas   +1 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, Volume 600, Issue 17, Page 2526-2546, September 2026.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

HD5 binds to both gp120 and CD4, and blocks the interaction of CD4 with gp120.

, 2013
(A) Effect of HD5 on HIV-1 envelope-mediated fusion after pre-incubation with effector cells (expressing the viral envelope) or target cells (expressing CD4 and the coreceptor).
Lia Vassena (172328), Paolo Lusso (172366), Lucinda Furci (305268), Monica Tolazzi (165833), Francesca Sironi (213418)   +4 more
core   +1 more source

Structure of an HIV-2 gp120 in Complex with CD4 [PDF]

Journal of Virology, 2016
ABSTRACT HIV-2 is a nonpandemic form of the virus causing AIDS, and the majority of HIV-2-infected patients exhibit long-term nonprogression. The HIV-1 and HIV-2 envelope glycoproteins, the sole targets of neutralizing antibodies, share 30 to 40% identity.
Davenport, Yunji W, West, Anthony P, Bjorkman, Pamela J   +2 more
openaire   +5 more sources

Real‐World Experience With Lenacapavir and/or Fostemsavir as Emerging Therapies for the Management of Multidrug‐Resistant HIV‐1 in Southeastern France

Journal of Medical Virology, Volume 98, Issue 9, September 2026.
ABSTRACT Lenacapavir and fostemsavir, two recently approved anti‐HIV‐1 agents, are promising options for people with difficult‐to‐treat HIV; however, real‐world data remain limited. This study aimed to describe the epidemiological, clinical, and virological profiles of people receiving combination antiretroviral regimens, including lenacapavir and/or ...
Syrine Boujamline, Celine Boschi, Hugo Bes‐Barlandier, Christelle Tomei, Amelie Menard, Saadia Mokhtari, Isabelle Ravaux, Yacine Belkhir, Nadege Neant, Caroline Solas, Philippe Colson, Matthieu Million   +11 more
wiley   +1 more source

The effect of LSA on the gp120-specific mAb binding.

, 2013
gp120-specific mAbs were incubated in the presence of various concentrations of LSA with immobilized gp120IIIB (A), gp120ADA (B) or gp120YU-2 (C) in a 96-well plate.
Qin Wang (109812), Hongyong Song (324484), Min Qiu (324481), Zhongping Yuan (324483), Zhiwei Wu (324485), Zhiwei Chen (254191), Ying Chu (324482)   +6 more
core   +1 more source

Antibodies to the CD4-binding site of HIV-1 gp120 suppress gp120-specific CD4 T cell response while enhancing antibody response

Infectious Agents and Cancer, 2008
Background The binding of Abs to the CD4-binding site (CD4bs) of HIV-1 envelope gp120 has been shown to obstruct the processing and generation of helper epitopes from this antigen, resulting in poor presentation of various gp120 epitopes by MHC class II ...
Hioe Catarina E, Chen Pei-de, Tuen Michael, Visciano Maria   +3 more
doaj   +1 more source

Targeting Human Immunodeficiency Virus Integrase Beyond the Active Site: The Discovery and Development of Allosteric Integrase Inhibitors

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Human immunodeficiency virus (HIV) allosteric integrase inhibitors (ALLINIs) offer a vital alternative to standard therapies by targeting noncatalytic sites. By inducing aberrant integrase multimerization, they disrupt viral maturation. This review explores their medicinal chemistry evolution, detailing structural insights, structure–activity ...
Francesco Saccoliti, Elisa Patacchini, Emanuele Cara, Laura Zarbo, Antonella Messore, Aurora Albano, Giuseppe Ruggieri, Valentina Noemi Madia, Luigi Scipione, Roberta Costi, Roberto Di Santo   +10 more
wiley   +1 more source

Signal peptide exchange alters HIV-1 envelope antigenicity and immunogenicity

Frontiers in Immunology
IntroductionHIV-1 envelope (Env) is the key target for antibodies (Abs) against the virus and thus an important HIV-1 vaccine component. Env is synthesized from a gp160 precursor with a signal peptide (SP) at its N-terminus.
Chitra Upadhyay, Priyanka Rao, Mohammad Amin Behzadi, Roya Feyznezhad, Gregory S. Lambert, Rajnish Kumar, Madhu Kumar, Weiming Yang, Xunqing Jiang, Christina C. Luo, Arthur Nadas, James Arthos, Xiang-Peng Kong, Hui Zhang, Catarina E. Hioe, Catarina E. Hioe, J. Andrew Duty   +16 more
doaj   +1 more source