Results 71 to 80 of about 46,924 (216)

Immunogenicity of the outer domain of a HIV-1 clade C gp120

Retrovirology, 2007
Background The possibility that a sub domain of a C clade HIV-1 gp120 could act as an effective immunogen was investigated. To do this, the outer domain (OD) of gp120CN54 was expressed and characterized in a construct marked by a re-introduced ...
Xu Xiaodong, Chen Hongying, Jones Ian M
doaj   +1 more source

Pulse waveform analysis in Zambian adults living with HIV on antiretroviral therapy: A cross‐sectional study of vascular dysfunction

Physiological Reports, Volume 14, Issue 8, April 2026.
Abstract People living with HIV (PLWH) experience a greater risk of cardiovascular disease due to HIV‐related vascular injury. Pulse waveform analysis can characterize arterial vascular dysfunction and this study compared arterial waveforms in PLWH on antiretroviral therapy (ART) with HIV‐negative controls.
Theresa Chikopela, Longa Kaluba, Shirley Mwaanga, Fastone M. Goma   +3 more
wiley   +1 more source

The Prefusogenic Intermediate of HIV-1 gp41 Contains Exposed C-peptide Regions [PDF]

, 2003
The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein is composed of a complex between the surface subunit gp120, which binds to cellular receptors, and the transmembrane subunit gp41.
Chan, David C., Koshiba, Takumi
core  

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, Volume 36, Issue 26, 30 March 2026.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

VH-RELATED IDIOTOPES DETECTED BY SITE-DIRECTED MUTAGENESIS [PDF]

, 1992
The function of the CD4 cell surface protein as coreceptor on T helper lymphocytes and as receptor for HIV makes this glycoprotein a prime target for an immune intervention with mAb.
Cheng, Y. H., Rieber, Ernst Peter, Riethmüller, Gert, Weiss, Elisabeth H., Weissenhorn, Winfried   +4 more
core   +1 more source

AFM force measurements of the gp120–sCD4 and gp120 or CD4 antigen–antibody interactions [PDF]

Biochemical and Biophysical Research Communications, 2011
Soluble CD4 (sCD4), anti-CD4 antibody, and anti-gp120 antibody have long been regarded as entry inhibitors in human immunodeficiency virus (HIV) therapy. However, the interactions between these HIV entry inhibitors and corresponding target molecules are still poorly understood.
Yong, Chen, Gucheng, Zeng, Sherry Shiyi, Chen, Qian, Feng, Zheng Wei, Chen   +4 more
openaire   +2 more sources

Theoretical Insights Into the Viral Protein–Metal Interaction Mechanisms for Antiviral Applications

ChemistryEurope, Volume 4, Issue 3, March 2026.
The atomic‐level understanding of the metal–protein interactions is still unclear to further improve the performance of noble metals in protein modifications. This work supplies critical theoretical insights from the atomic level to demonstrate the interaction behaviors between selective SARS‐CoV‐2 Spike protein fragments and Ag/Au.
Qiuyang Lu, Mingzi Sun, Lu Lu, Tong Wu, Zikang Li, Baian Chen, Ziqi Zhou, Shipeng Liang, Hon Ho Wong, Cheuk Hei Chan, Bolong Huang   +10 more
wiley   +1 more source

Infectious agents in atherosclerotic cardiovascular diseases through oxidative stress [PDF]

, 2017
Accumulating evidence demonstrates that vascular oxidative stress is a critical feature of atherosclerotic process, potentially triggered by several infectious agents that are considered as risk co-factors for the atherosclerotic cardiovascular diseases (
Di Pietro, M, Falasca, F, Filardo, S, Sessa, R., Turriziani, O   +4 more
core   +2 more sources

CD4‐Based Chimeric Antigen Receptor (CAR)‐T Cells With Resistance to HIV‐1 Infection and Enhanced Anti‐HIV Efficacy: Covalent Interaction Between CD4‐CAR and HIV‐1 Envelope Glycoprotein

Journal of Medical Virology, Volume 98, Issue 3, March 2026.
ABSTRACT The current highly active antiretroviral therapy (HAART or ART) effectively suppresses de novo HIV‐1 infection but fails to eliminate HIV reservoir cells, which leads to rapid viral rebound upon ART cessation. Chimeric antigen receptor (CAR) T cells engineered to target HIV‐1 Env⁺ cells offer a promising strategy to eliminate or control these ...
Yaoxian Lou, Xiuting He, Guangming Li, Martin Sikhondze, Jianping Ma, Hongwei Du, Xin Ouyang, Gianpietro Dotti, Mohammad Sajadi, Lishan Su   +9 more
wiley   +1 more source

Signal peptide exchange alters HIV-1 envelope antigenicity and immunogenicity

Frontiers in Immunology
IntroductionHIV-1 envelope (Env) is the key target for antibodies (Abs) against the virus and thus an important HIV-1 vaccine component. Env is synthesized from a gp160 precursor with a signal peptide (SP) at its N-terminus.
Chitra Upadhyay, Priyanka Rao, Mohammad Amin Behzadi, Roya Feyznezhad, Gregory S. Lambert, Rajnish Kumar, Madhu Kumar, Weiming Yang, Xunqing Jiang, Christina C. Luo, Arthur Nadas, James Arthos, Xiang-Peng Kong, Hui Zhang, Catarina E. Hioe, Catarina E. Hioe, J. Andrew Duty   +16 more
doaj   +1 more source