Results 91 to 100 of about 34,750 (223)

Nuclear phosphoinositide-specific phospholipase C β1 controls cytoplasmic CCL2 mRNA levels in HIV-1 gp120-stimulated primary human macrophages.

PLoS ONE, 2013
HIV-1 envelope glycoprotein gp120 induces, independently of infection, the release of CCL2 from macrophages. In turn, this chemokine acts as an autocrine factor enhancing viral replication.
Francesca Spadaro, Serena Cecchetti, Cristina Purificato, Michela Sabbatucci, Franca Podo, Carlo Ramoni, Sandra Gessani, Laura Fantuzzi   +7 more
doaj   +1 more source

The first structure of HIV-1 gp120 with CD4 and CCR5 receptors

Cell & Bioscience, 2019
Shaik et al. recently published online the cryo-electron microscopy structure of HIV-1 gp120 in complex with CD4 and CCR5 receptors. This is the first structure of the ternary HIV-1 gp120/CD4/CCR5 complex.
Yongjun Guan
doaj   +1 more source

Interactions between coevolving residues in GP120.

, 2015
(A) The contact (hydrogen bonds) maps from molecular dynamics simulation of GP120; (B-F) Snapshots of the interactions between coevolving residues in protein sector of gp120 during molecular dynamics simulations of 0 ns, 1 ns, 2 ns, 5 ns, and 10 ns ...
Yuedong Gao (691658), Gonghua Li (691659), Jingfei Huang (240104), Yuqi Zhao (3512822), Yanjie Wang (444557)   +4 more
core   +1 more source

Comprehensive Characterization of Reference Standard Lots of HIV-1 Subtype C Gp120 Proteins for Clinical Trials in Southern African Regions

Vaccines, 2016
Two HIV-1 subtype C gp120 protein candidates were the selected antigens for several experimental vaccine regimens now under evaluation in HVTN 100 Phase I/II clinical trial aiming to support the start of the HVTN 702 Phase IIb/III trial in southern ...
Zihao Wang, Clarisse Lorin, Marguerite Koutsoukos, David Franco, Babak Bayat, Ying Zhang, Andrea Carfi, Susan W. Barnett, Frederick Porter   +8 more
doaj   +1 more source

Mapping of the HD5-binding site in HIV-1 gp120.

, 2013
Competition of HD5 with a panel of anti-gp120 mAbs with various epitope specificity for binding to plastic-immobilized recombinant gp120 in ELISA. The plates were coated with gp120BaL at 2 µg/mL; HD5 at 5.6 µM was added prior to the anti-gp120 mAbs, all ...
Lia Vassena (172328), Paolo Lusso (172366), Lucinda Furci (305268), Monica Tolazzi (165833), Francesca Sironi (213418)   +4 more
core   +1 more source

Involvement of metabotropic glutamate receptor 5, AKT/PI3K Signaling and NF-κB pathway in methamphetamine-mediated increase in IL-6 and IL-8 expression in astrocytes

Journal of Neuroinflammation, 2012
Methamphetamine (MA) is one of the commonly used illicit drugs and the central nervous system toxicity of MA is well documented. The mechanisms contributing to this toxicity have not been fully elucidated.
Shah Ankit, Silverstein Peter S, Singh Dhirendra P, Kumar Anil   +3 more
doaj   +1 more source

Design, synthesis and evaluation of peptide libraries as potential anti-HIV compounds, via inhibition of gp120/cell membrane interactions, using the gp120/cd4/fab17 crystal structure

, 2002
The crystal structure of a gp120/CD4/Fab17b complex was analysed leading to the design of several peptide libraries in the hope of obtaining novel gp120/cell membrane receptor interaction inhibitors, especially inhibitors of gp120/CD4 and gp120/chemokine
Pritchard, Martyn, Klimkait, Thomas, Boussard, Cyrille, Doyle, Valerie E., Mahmood, Naheed, Gilbert, Ian H. ; id_orcid   +5 more
core   +1 more source

Mimicking protein-protein interactions through peptide-peptide interactions: HIV-1 gp120 and CXCR4

Frontiers in Immunology, 2013
We have recently designed a soluble synthetic peptide that functionally mimics the HIV-1 coreceptor CXCR4, which is a chemokine receptor that belongs to the family of seven-transmembrane GPCRs.
Andrea eGross, Kalle eMöbius, Christina eHaußner, Norbert eDonhauser, Barbara eSchmidt, Jutta eEichler   +5 more
doaj   +1 more source

MCPs elicit antibodies to cryptic epitopes of gp120.

, 2013
(A) Binding of MAb 11A8 to gp120 is not inhibited by antisera to gp120. Competition for gp120MN binding of biotinylated MAb 11A8 and murine sera was evaluated in ELISA as described in Materials and Methods.
Hanna C. Kelker (368168), Fred T. Valentine (368170), Vincenza R. Itri (368169)   +2 more
core   +1 more source

gp120 shedding assay.

, 2012
(A) The CD4-induced gp120 shedding assay was done by Western blot analysis of Envs obtained from supernatants of 293T cells transfected with the plasmid DNA encoding 4.J2 and YU2 Env variants as well as JRFL Env. HIV-1 gp120 shedding upon binding of sCD4
Jayanta Bhattacharya (131652), Rajesh Ringe (131627)   +1 more
core   +1 more source