Results 91 to 100 of about 46,924 (216)

Increasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational Design [PDF]

, 2011
Antibodies against the CD4 binding site (CD4bs) on the HIV-1 spike protein gp120 can show exceptional potency and breadth. We determined structures of NIH45-46, a more potent clonal variant of VRC01, alone and bound to gp120. Comparisons with VRC01-gp120
Abadir, Alexander, Bjorkman, Pamela J., Diskin, Ron, Gao, Han, Gnanapragasam, Priyanthi N. P., Klein, Florian, Marcovecchio, Paola M., Nussenzweig, Michel C., Scheid, Johannes F., Seaman, Michael S., West, Anthony P., Jr.   +10 more
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Involvement of metabotropic glutamate receptor 5, AKT/PI3K Signaling and NF-κB pathway in methamphetamine-mediated increase in IL-6 and IL-8 expression in astrocytes

Journal of Neuroinflammation, 2012
Methamphetamine (MA) is one of the commonly used illicit drugs and the central nervous system toxicity of MA is well documented. The mechanisms contributing to this toxicity have not been fully elucidated.
Shah Ankit, Silverstein Peter S, Singh Dhirendra P, Kumar Anil   +3 more
doaj   +1 more source

Stereochemistry of Polypeptide Conformation in Coarse Grained Analysis

, 2013
The conformations available to polypeptides are determined by the interatomic forces acting on the peptide units, whereby backbone torsion angles are restricted as described by the Ramachandran plot.
Hendrickson, Wayne A, Korkut, Anil
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A saposin-lipoprotein nanoparticle system for membrane proteins. [PDF]

, 2016
A limiting factor in membrane protein research is the ability to solubilize and stabilize such proteins. Detergents are used most often for solubilizing membrane proteins, but they are associated with protein instability and poor compatibility with ...
Armache, Jean-Paul, Briggs, John AG, Cheng, Yifan, Flayhan, Ali, Frauenfeld, Jens, Garoff, Henrik, Guettou, Fatma, Jegerschöld, Caroline, Löving, Robin, Löw, Christian, Moberg, Per, Nordlund, Pär, Sonnen, Andreas F-P, Zhu, Lin   +13 more
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Mimicking protein-protein interactions through peptide-peptide interactions: HIV-1 gp120 and CXCR4

Frontiers in Immunology, 2013
We have recently designed a soluble synthetic peptide that functionally mimics the HIV-1 coreceptor CXCR4, which is a chemokine receptor that belongs to the family of seven-transmembrane GPCRs.
Andrea eGross, Kalle eMöbius, Christina eHaußner, Norbert eDonhauser, Barbara eSchmidt, Jutta eEichler   +5 more
doaj   +1 more source

RNA interference approaches for treatment of HIV-1 infection. [PDF]

, 2015
HIV/AIDS is a chronic and debilitating disease that cannot be cured with current antiretroviral drugs. While combinatorial antiretroviral therapy (cART) can potently suppress HIV-1 replication and delay the onset of AIDS, viral mutagenesis often leads to
Bobbin, Maggie L, Burnett, John C, Rossi, John J   +2 more
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Use of silver nanoparticles increased inhibition of cell-associated HIV-1 infection by neutralizing antibodies developed against HIV-1 envelope proteins

Journal of Nanobiotechnology, 2011
Background HIV/AIDS pandemic is a worldwide public health issue. There is a need for new approaches to develop new antiviral compounds or other therapeutic strategies to limit viral transmission.
Garza Treviño Elsa N, Ixtepan-Turrent Liliana, Lara Humberto H, Singh Dinesh K   +3 more
doaj   +1 more source

The neck region of the C-type lectin DC-SIGN regulates its surface spatiotemporal organization and virus-binding capacity on antigen presenting cells [PDF]

, 2012
The C-type lectin DC-SIGN expressed on dendritic cells (DCs) facilitates capture and internalization of a plethora of different pathogens. Although it is known that DC-SIGN organizes in nanoclusters at the surface of DCs, the molecular mechanisms ...
Alvarez, Ashby, Bakker, Banchereau, Bonifaz, Cambi, Cambi, Cambi, Cambi, Cambi, Chung, de Bakker, de Witte, Feinberg, Feinberg, Gaborski, Geijtenbeek, Geijtenbeek, Geijtenbeek, Geijtenbeek, Gringhuis, Itano, Itano, Khoo, Koopman, Liu, Liu, Lozach, Lozach, Ludwig, Menon, Mitchell, Neumann, Pohlmann, Puig-Kröger, Rappocciolo, Regan, Serrano-Gómez, Sierra-Filardi, Simmons, Smith, Soilleux, Steinman, Tacken, Tacken, Théry, Trombetta, van Kooyk, Yu, Zhu   +49 more
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HIV-1 gp41-targeting fusion inhibitory peptides enhance the gp120-targeting protein-mediated inactivation of HIV-1 virions

Emerging Microbes and Infections, 2017
Protein- or peptide-based viral inactivators are being developed as novel antiviral drugs with improved efficacy, pharmacokinetics and toxicity profiles because they actively inactivate cell-free human immunodeficiency virus type 1 (HIV-1) virions before
Qianqian Qi, Qian Wang, Weizao Chen, Lanying Du, Dimiter S Dimitrov, Lu Lu, Shibo Jiang   +6 more
doaj   +1 more source

Characterization of the longitudinal HIV-1 quasispecies evolution in HIV-1 infected individuals co-infected with Mycobacterium tuberculosis [PDF]

, 2010
One of the earliest and most striking observations made about HIV is the extensive genetic variation that the virus has within individual hosts, particularly in the hypervariable regions of the env gene which is divided into 5 variable regions (V1-V5 ...
Leulebirhan, Tsigereda Biru
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