Results 31 to 40 of about 24,116 (179)
The HIV-1 Env gp120 Inner Domain Shapes the Phe43 Cavity and the CD4 Binding Site
mBio, 2020 The HIV-1 envelope glycoproteins (Env) undergo conformational changes upon interaction of the gp120 exterior glycoprotein with the CD4 receptor. The gp120 inner domain topological layers facilitate the transition of Env to the CD4-bound conformation. CD4
Jérémie Prévost +23 more
doaj +1 more source
HIV-gp120 and physical dependence to buprenorphine [PDF]
Drug and Alcohol Dependence, 2015 Opioids are among the most effective and commonly used analgesics in clinical practice for severe pain. However, the use of opioid medications is clinically limited by several adverse properties including dependence. While opioid dependence is a complex health condition, the treatment of HIV-infected individuals with opioid dependence presents ...
J, Palma, M E, Abood, K, Benamar
openaire +2 more sources
Chemistry – A European Journal, EarlyView.The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik +3 more
wiley +1 more source
Cancer pain: current practice and emerging targets
British Journal of Pharmacology, EarlyView.Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye +5 more
wiley +1 more source
Myeloid-derived suppressor cells and the pathogenesis of human immunodeficiency virus infection
Open Biology, 2021 There are several mechanisms by which human immunodeficiency virus (HIV) can mediate immune dysfunction and exhaustion during the course of infection.
Mahmoud Mohammad Yaseen +2 more
doaj +1 more source
Binding of HIV‐1 gp120 to the nicotinic receptor [PDF]
FEBS Letters, 1992 We previously described a significant sequence homology between HIV‐1 gp120 and the functional sites responsible for the specific binding of snake curare‐mimetic neurotoxins and rabies virus glycoprotein to the nicotinic acetylcholine receptor. Here we report findings about the existence of a mechanism of functional molecular mimicry which could enable
Bracci, Luisa +3 more
openaire +4 more sources
Structural insights into tyrosine sulfation of CCR5 by human tyrosylprotein sulfotransferase‐1
The FEBS Journal, EarlyView.Structural analysis of human tyrosylprotein sulfotransferase‐1 (hTPST1) bound to a CCR5 N‐terminal peptide reveals how hTPST1 recognizes the Tyr3 sulfation site. Structure‐guided models of additional CCR5 sulfation states and full‐length assemblies provide a framework for understanding CCR5 tyrosine sulfation, a post‐translational modification relevant
Shinnosuke Tanaka +10 more
wiley +1 more source
Glia, Volume 74, Issue 8, August 2026.Single‐nucleus multiomic profiling of postmortem brain reveals coordinated immune, metabolic, and epigenomic reprogramming in glia of people with HIV consistent with maladaptive trained immunity sustaining neuroinflammation in HAND. ABSTRACT HIV‐associated neurocognitive disorders (HAND) remain prevalent in people with HIV (PWH) despite effective ...
Siera Martinez +8 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2019 Activation of the p75 neurotrophin receptor (p75NTR), by the proneurotrophin brain-derived neurotrophic factor (proBDNF), triggers loss of synapses and promotes neuronal death.
Andrew Speidell +5 more
doaj +1 more source
Malang Neurology Journal, 2021 Background: Neuro-inflammation plays a role in the pathogenesis of HIV-associated dementia (HIV). Activation of microglia is essential for triggering inflammatory-mediated neurotoxicity.
Masruroh Rahayu +3 more
doaj +1 more source