Results 11 to 20 of about 46,924 (216)

Development of an Ultrasensitive ELISA Assay for Evaluating HIV-1 Envelope Glycoprotein as a Marker for Targeted Activator of Cell Kill [PDF]

Viruses
The HIV-1 envelope glycoprotein gp120 is prominently exposed on the surface of both HIV-1 virions and infected host cells, serving as a key marker of infection.
Guoxin Wu, Luca Sardo, Yuan Li, Steven D. Heron, BaoJen Shyong, Matthew Mazur, Daniel M. Gorman, Carl J. Balibar, Brian C. Magliaro, Craig Leach, Thomas Rush, Bonnie J. Howell   +11 more
doaj   +2 more sources

Highly efficient production of HIV-1AD8 gp120 in mammalian cells [PDF]

Journal of Virology
Human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins (Envs) interact with the CD4 receptor and CCR5/CXCR4 coreceptor expressed on target cells to mediate viral entry. Infection is initiated when the HIV-1 gp120 subunit of Envs binds to host
Tanvi Mathur, Shamim Ahmed, Durgadevi Parthasarathy, Alon Herschhorn   +3 more
doaj   +2 more sources

Immune non‐response despite effective antiretroviral therapy in people living with HIV: A review of potential mechanisms, biomarkers and therapeutic approaches [PDF]

HIV Medicine, Volume 27, Issue 4, Page 498-512, April 2026.
Abstract Introduction A proportion of people living with HIV (PLWH) fail to restore their CD4 count or their CD4/CD8 ratio despite effective antiretroviral therapy (ART). PLWH with immune non‐response (INR) are at a higher risk of both AIDS and non‐AIDS events. The underlying mechanisms of INR remain unclear.
Charlotte Silvestre, Antoine Gross, Alain Makinson   +2 more
wiley   +2 more sources

Exploring the impact of baseline and on‐treatment variables on durability of responses to fostemsavir through weeks 96 and 192 in the phase 3 BRIGHTE study [PDF]

HIV Medicine, Volume 27, Issue 3, Page 386-396, March 2026.
Abstract Objectives The gp120‐directed attachment inhibitor fostemsavir was effective in people with multidrug‐resistant (MDR) HIV‐1 in the BRIGHTE study. Understanding factors associated with virologic response can help clinicians optimize treatment and identify individuals for fostemsavir‐based regimens.
M. Gartland, X. Wang, Q. Liao, B. Li, F. Du, M. Krystal, A. R. Tenorio, A. Pierce, J. R. Castillo‐Mancilla   +8 more
wiley   +2 more sources

Human immunodeficiency virus 1 glycoprotein 120 induces endoplasmic reticulum stress in neurons [PDF]

Cell Death and Disease
People living with Human Immunodeficiency Virus (HIV) (PLWH) may develop HIV-associated neurocognitive disorder (HAND) despite the use of antiretroviral therapy.
Christy Agbey, Lee A. Campbell, Thieu Phan, Gerard Ahern, Italo Mocchetti   +4 more
doaj   +2 more sources

Stoichiometry of HIV-1 envelope glycoprotein protomers with changes that stabilize or destabilize the pretriggered conformation [PDF]

mBio
During human immunodeficiency virus (HIV-1) entry into host cells, binding to the receptors, CD4 and CCR5/CXCR4, triggers conformational changes in the metastable envelope glycoprotein (Env) trimer ((gp120-gp41)3).
Zhiqing Zhang, Saumya Anang, Qian Wang, Hanh T. Nguyen, Hung-Ching Chen, Ta-Jung Chiu, Derek Yang, Amos B. Smith, Joseph G. Sodroski   +8 more
doaj   +2 more sources

Mapping the complete glycoproteome of virion-derived HIV-1 gp120 provides insights into broadly neutralizing antibody binding [PDF]

, 2016
The surface envelope glycoprotein (SU) of Human immunodeficiency virus type 1 (HIV-1), gp120SU plays an essential role in virus binding to target CD4+ T-cells and is a major vaccine target.
Bess, JW, Binet, D, Bouché, L, Canis, K, Chertova, E, Dell, A, Desrosiers, RC, Haslam, SM, Keele, BF, Lifson, JD, Morris, HR, North, SJ, O'Connor, MJ, Pang, PC, Panico, M, Rahman, D   +15 more
core   +1 more source

HIV-1 gp120 mannoses induce immunosuppressive responses from dendritic cells.

PLoS Pathogens, 2007
The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp120 is a vaccine immunogen that can signal via several cell surface receptors.
Meimei Shan, Per Johan Klasse, Kaustuv Banerjee, Antu K Dey, Sai Prasad N Iyer, Robert Dionisio, Dustin Charles, Lila Campbell-Gardener, William C Olson, Rogier W Sanders, John P Moore   +10 more
doaj   +1 more source

Effect of naringin on gp120-induced injury mediated by P2X7 receptors in rat primary cultured microglia. [PDF]

PLoS ONE, 2017
Human immunodeficiency virus type-1 (HIV-1) envelope glycoprotein 120 has been shown to activate microglia, causing release of inflammatory and toxic factors.
Qiang Chen, Hui Wu, Jia Tao, Chenglong Liu, Zeyu Deng, Yang Liu, Guoqiao Chen, Baoyun Liu, Changshui Xu   +8 more
doaj   +1 more source

Long Non-coding RNA Uc.48+ Small Interfering RNA Alleviates Neuroinflammatory Hyperalgesia in Gp120-Treated Rats via the P2Y12 Receptor

Frontiers in Neuroscience, 2021
Human immunodeficiency virus envelope glycoprotein 120 (gp120) leads to hyperalgesia. Long non-coding RNAs are characterized by the lack of a protein-coding sequence and may contribute to the development and maintenance of inflammatory and ...
Lichao Peng, Bing Wu, Bing Wu, Liran Shi, Liran Shi, Lifang Zou, Lifang Zou, Lin Li, Lin Li, Runan Yang, Runan Yang, Xiumei Xu, Xiumei Xu, Guilin Li, Guilin Li, Shuangmei Liu, Shuangmei Liu, Chunping Zhang, Chunping Zhang, Shangdong Liang, Shangdong Liang   +20 more
doaj   +1 more source