Results 11 to 20 of about 34,750 (223)

Blood-Brain Barrier Abnormalities Caused by HIV-1 gp120: Mechanistic and Therapeutic Implications [PDF]

The Scientific World Journal, 2012
The blood-brain barrier (BBB) is compromised in many systemic and CNS diseases, including HIV-1 infection of the brain. We studied BBB disruption caused by HIV-1 envelope glycoprotein 120 (gp120) as a model.
Jean-Pierre Louboutin, David S. Strayer
doaj   +3 more sources

HIV-1 gp120 mannoses induce immunosuppressive responses from dendritic cells.

PLoS Pathogens, 2007
The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp120 is a vaccine immunogen that can signal via several cell surface receptors.
Meimei Shan, Per Johan Klasse, Kaustuv Banerjee, Antu K Dey, Sai Prasad N Iyer, Robert Dionisio, Dustin Charles, Lila Campbell-Gardener, William C Olson, Rogier W Sanders, John P Moore   +10 more
doaj   +2 more sources

HIV-gp120

, 2021
Deciphering the glycosylation of viral envelope (Env) glycoprotein is critical for evaluating viral invasion and the host’s immune response, and developing preventive vaccines and antiviral drugs.
Yong Zhang (9437864)
core   +1 more source

Novel Cell type-specific aptamer-siRNA delivery system for HIV-1 therapy [PDF]

, 2007
The successful use of small interfering RNAs (siRNAs) for therapeutic purposes requires safe and efficient delivery to specific cells and tissues. Here we demonstrate cell type-specific delivery of anti-HIV siRNAs via fusion to an anti-gp120 aptamer. The
Haitang Li, John Zaia, John Rossi, Jiehua Zhou, Shirley Li   +4 more
core   +1 more source

Effect of naringin on gp120-induced injury mediated by P2X7 receptors in rat primary cultured microglia. [PDF]

PLoS ONE, 2017
Human immunodeficiency virus type-1 (HIV-1) envelope glycoprotein 120 has been shown to activate microglia, causing release of inflammatory and toxic factors.
Qiang Chen, Hui Wu, Jia Tao, Chenglong Liu, Zeyu Deng, Yang Liu, Guoqiao Chen, Baoyun Liu, Changshui Xu   +8 more
doaj   +1 more source

Surfactant protein D inhibits HIV-1 infection of target cells via interference with gp120-CD4 interaction and modulates pro-inflammatory cytokine production [PDF]

, 2014
© 2014 Pandit et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Al-Mozaini, MA, Pandit Hrishikesh, Yadav Ajit Kumar, Gopal, S, Idicula-Thomas, S, Uday Kishore (504246), Al-Mozaini Maha Ahmed, Vijay Kulkarni, Himangi Warke, Gopal Sandhya, Asif S Qaseem, Sonawani, A, Kulkarni, V, Warke Himangi, Hrishikesh Pandit, Patil, A, Himangi Warke (504243), Idicula-Thomas Susan, Anushree Patil (600836), Gajbhiye, R, Yadav, AK, Sandhya Gopal (600833), Kulkarni Vijay, Archana Sonawani (413679), Warke, H, Susan Idicula-Thomas, Taruna Madan, Sonawani Archana, Asif S. Qaseem, Maha Ahmed Al-Mozaini, Archana Sonawani, Hrishikesh Pandit (504240), Ajit Kumar Yadav (600834), Rahul Gajbhiye (600837), Qaseem, AS, Madan, T, Madan Taruna, Sandhya Gopal, Ajit Kumar Yadav, Qaseem Asif S., Gajbhiye Rahul, Rahul Gajbhiye, Patil Anushree, Pandit, H, Asif S. Qaseem (600835), Kishore Uday, Anushree Patil, Vijay Kulkarni (600838), Maha Ahmed Al-Mozaini (600839), Kishore, U, Taruna Madan (504241), Susan Idicula-Thomas (318974), Uday Kishore   +52 more
core   +2 more sources

The HIV-1 envelope protein gp120 is captured and displayed for B cell recognition by SIGN-R1+ lymph node macrophages

eLife, 2015
The HIV-1 envelope protein gp120 is both the target of neutralizing antibodies and a major focus of vaccine efforts; however how it is delivered to B cells to elicit an antibody response is unknown.
Chung Park, James Arthos, Claudia Cicala, John H Kehrl   +3 more
doaj   +1 more source

Entry Inhibitors Directed Towards Glycoprotein gp120: An Overview on a Promising Target for HIV-1 Therapy [PDF]

, 2013
In spite of the unquestionable positive impact of HAART in the treatment of HIV infection, the discovery and development of novel agents directed towards other targets of the replicative cycle of the virus that differ from those targeted by the ...
Flores, Aida, Quesada, Ernesto, Quesada del Sol, Ernesto, Flores Aguilar-Amat, Aída   +3 more
core   +2 more sources

HIV-1gp120 induces neuronal apoptosis through enhancement of 4-aminopyridine-senstive outward K+ currents. [PDF]

PLoS ONE, 2011
Human immunodeficiency virus type 1 (HIV-1)-associated dementia (HAD) usually occurs late in the course of HIV-1 infection and the mechanisms underlying HAD pathogenesis are not well understood. Accumulating evidence indicates that neuronal voltage-gated
Lina Chen, Jianuo Liu, Changshui Xu, James Keblesh, Weijin Zang, Huangui Xiong   +5 more
doaj   +1 more source

Endocytic Trafficking of HIV gp120 is Mediated by Dynamin and Plays a Role in gp120 Neurotoxicity [PDF]

Journal of Neuroimmune Pharmacology, 2017
Neurons that endocytose the human immunodeficiency virus-1 (HIV) protein gp120 exhibit neurite retraction and activation of caspase-3, suggesting that the endocytic process may be crucial for gp120-mediated neuronal injury. The goal of this study is to demonstrate that internalization and accumulation of gp120 play a role in its neurotoxic effects.
Erin D. Wenzel, Alessia Bachis, Valeria Avdoshina, Francesca Taraballi, Ennio Tasciotti, Italo Mocchetti   +5 more
openaire   +2 more sources