Results 11 to 20 of about 24,116 (179)
Neurobiology of Disease, 2010 HIV-1 effects on the blood–brain barrier (BBB) structure and function are still poorly understood in animal models based on direct administration of recombinant HIV proteins.
Jean-Pierre Louboutin +5 more
doaj +1 more source
HIV-1 gp120 mannoses induce immunosuppressive responses from dendritic cells.
PLoS Pathogens, 2007 The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp120 is a vaccine immunogen that can signal via several cell surface receptors.
Meimei Shan +10 more
doaj +1 more source
A Chimeric HIV-1 gp120 Fused with Vaccinia Virus 14K (A27) Protein as an HIV Immunogen. [PDF]
PLoS ONE, 2015 In the HIV vaccine field, there is a need to produce highly immunogenic forms of the Env protein with the capacity to trigger broad B and T-cell responses.
Aneesh Vijayan +8 more
doaj +1 more source
Frontiers in Neuroscience, 2021 Human immunodeficiency virus envelope glycoprotein 120 (gp120) leads to hyperalgesia. Long non-coding RNAs are characterized by the lack of a protein-coding sequence and may contribute to the development and maintenance of inflammatory and ...
Lichao Peng +20 more
doaj +1 more source
Endocytic Trafficking of HIV gp120 is Mediated by Dynamin and Plays a Role in gp120 Neurotoxicity [PDF]
Journal of Neuroimmune Pharmacology, 2017 Neurons that endocytose the human immunodeficiency virus-1 (HIV) protein gp120 exhibit neurite retraction and activation of caspase-3, suggesting that the endocytic process may be crucial for gp120-mediated neuronal injury. The goal of this study is to demonstrate that internalization and accumulation of gp120 play a role in its neurotoxic effects.
Erin D. Wenzel +5 more
openaire +2 more sources
Effect of naringin on gp120-induced injury mediated by P2X7 receptors in rat primary cultured microglia. [PDF]
PLoS ONE, 2017 Human immunodeficiency virus type-1 (HIV-1) envelope glycoprotein 120 has been shown to activate microglia, causing release of inflammatory and toxic factors.
Qiang Chen +8 more
doaj +1 more source
Specific HIV gp120-cleaving Antibodies Induced by Covalently Reactive Analog of gp120 [PDF]
Journal of Biological Chemistry, 2003 We report the results of efforts to strengthen and direct the natural nucleophilic activity of antibodies (Abs) for the purpose of specific cleavage of the human immunodeficiency virus-1 coat protein gp120. Phosphonate diester groups previously reported to form a covalent bond with the active site nucleophile of serine proteases (Paul, S., Tramontano ...
Sudhir, Paul +7 more
openaire +2 more sources
AFM force measurements of the gp120–sCD4 and gp120 or CD4 antigen–antibody interactions [PDF]
Biochemical and Biophysical Research Communications, 2011 Soluble CD4 (sCD4), anti-CD4 antibody, and anti-gp120 antibody have long been regarded as entry inhibitors in human immunodeficiency virus (HIV) therapy. However, the interactions between these HIV entry inhibitors and corresponding target molecules are still poorly understood.
Yong, Chen +4 more
openaire +2 more sources
eLife, 2015 The HIV-1 envelope protein gp120 is both the target of neutralizing antibodies and a major focus of vaccine efforts; however how it is delivered to B cells to elicit an antibody response is unknown.
Chung Park +3 more
doaj +1 more source
HIV-1gp120 induces neuronal apoptosis through enhancement of 4-aminopyridine-senstive outward K+ currents. [PDF]
PLoS ONE, 2011 Human immunodeficiency virus type 1 (HIV-1)-associated dementia (HAD) usually occurs late in the course of HIV-1 infection and the mechanisms underlying HAD pathogenesis are not well understood. Accumulating evidence indicates that neuronal voltage-gated
Lina Chen +5 more
doaj +1 more source