Specific HIV gp120-cleaving Antibodies Induced by Covalently Reactive Analog of gp120 [PDF]
Journal of Biological Chemistry, 2003 We report the results of efforts to strengthen and direct the natural nucleophilic activity of antibodies (Abs) for the purpose of specific cleavage of the human immunodeficiency virus-1 coat protein gp120. Phosphonate diester groups previously reported to form a covalent bond with the active site nucleophile of serine proteases (Paul, S., Tramontano ...
Sudhir, Paul +7 more
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Durable cytotoxic immune responses against gp120 elicited by recombinant SV40 vectors encoding HIV-1 gp120 +/- IL-15. [PDF]
, 2004 BACKGROUND: A vaccine that elicits durable, powerful anti-HIV immunity remains an elusive goal. In these studies we tested whether multiple treatments with viral vector-delivered HIV envelope antigen (gp120), with and without IL-15, could help to ...
Strayer, David S +4 more
core +5 more sources
Peptides presenting the binding site of human CD4 for the HIV-1 envelope glycoprotein gp120
Beilstein Journal of Organic Chemistry, 2012 Based on the structure of the HIV-1 glycoprotein gp120 in complex with its cellular receptor CD4, we have designed and synthesized peptides that mimic the binding site of CD4 for gp120.
Julia Meier +3 more
doaj +1 more source
AFM force measurements of the gp120–sCD4 and gp120 or CD4 antigen–antibody interactions [PDF]
Biochemical and Biophysical Research Communications, 2011 Soluble CD4 (sCD4), anti-CD4 antibody, and anti-gp120 antibody have long been regarded as entry inhibitors in human immunodeficiency virus (HIV) therapy. However, the interactions between these HIV entry inhibitors and corresponding target molecules are still poorly understood.
Yong, Chen +4 more
openaire +2 more sources
Insights from the interfaces of HIV-1 envelope (ENV) trimer viral protein GP160 (GP120-GP41)
International Journal of Research in Pharmaceutical Sciences, 2021 The Human Immunodeficiency Virus (HIV-1) type 1 viral protein is a life threatening virus causing HIV/AIDS in infected humans. The HIV-1 envelope (ENV) trimer glycoprotein GP160 (GP120-GP41) is gaining attention in recent years as a potential vaccine ...
Christina Nilofer, Arumugam Mohanapriya
doaj +1 more source
Physiological Corticosterone Attenautes GP120-Mediated Microglial Activation and is Associated with Reduced Anxiety-Like Behavior in GP120-Expressing Mice [PDF]
, 2022 Human immunodeficiency virus (HIV) persists as a global pandemic. Despite the benefits of combinatorial antiretroviral therapies (cART), virotoxic HIV proteins are still detectable within the central nervous system and approximately half of all cART ...
Moss, Emaya Marie
core +1 more source
, 2005 Single-chain derivatives of JRFL gp120 linked to the first two domains of human CD4 $(gp120-CD4_D_1_2)$ or to the CD4 miniprotein analog CD4M9 (gp120-M9), have been constructed.
Citron, Michael +14 more
core +2 more sources
X4 Human immunodeficiency virus type 1 gp120 promotes human hepatic stellate cell activation and collagen I expression through interactions with CXCR4. [PDF]
PLoS ONE, 2012 Patients coinfected with HIV-1 and HCV develop more rapid liver fibrosis than patients monoinfected with HCV. HIV RNA levels correlate with fibrosis progression implicating HIV directly in the fibrotic process.
Feng Hong +4 more
doaj +1 more source
Allosteric modulation of the HIV-1 gp120-gp41 association site by adjacent gp120 variable region 1 (V1) N-glycans linked to neutralization sensitivity. [PDF]
PLoS Pathogens, 2013 The HIV-1 gp120-gp41 complex, which mediates viral fusion and cellular entry, undergoes rapid evolution within its external glycan shield to enable escape from neutralizing antibody (NAb).
Heidi E Drummer +6 more
doaj +1 more source
Induction of cytolytic T lymphocytes directed towards the V3 loop of the human immunodeficiency virus type 1 external glycoprotein gp120 by p55gag/V3 chimeric vaccinia viruses [PDF]
, 1993 T cell-mediated cytotoxicity may play an important role in controlling infection by human immunodeficiency virus (HIV). In order to study the ability of rationally designed antigens to induce cytolytic T lymphocytes (CTLs) we replaced stretches of 30 to ...
Deml, Ludwig +4 more
core +1 more source