Peptides presenting the binding site of human CD4 for the HIV-1 envelope glycoprotein gp120
Beilstein Journal of Organic Chemistry, 2012 Based on the structure of the HIV-1 glycoprotein gp120 in complex with its cellular receptor CD4, we have designed and synthesized peptides that mimic the binding site of CD4 for gp120.
Julia Meier +3 more
doaj +1 more source
Molecular evolution of HIV-1 CRF01_AE Env in Thai patients. [PDF]
PLoS ONE, 2011 BACKGROUND: The envelope glycoproteins (Env), gp120 and gp41, are the most variable proteins of human immunodeficiency virus type 1 (HIV-1), and are the major targets of humoral immune responses against HIV-1.
Samatchaya Boonchawalit +11 more
doaj +1 more source
Blood-Brain Barrier Abnormalities Caused by HIV-1 gp120: Mechanistic and Therapeutic Implications
The Scientific World Journal, 2012 The blood-brain barrier (BBB) is compromised in many systemic and CNS diseases, including HIV-1 infection of the brain. We studied BBB disruption caused by HIV-1 envelope glycoprotein 120 (gp120) as a model.
Jean-Pierre Louboutin, David S. Strayer
doaj +1 more source
Structural dynamics of HIV-1 envelope Gp120 outer domain with V3 loop. [PDF]
PLoS ONE, 2012 BACKGROUND: The net charge of the hypervariable V3 loop on the HIV-1 envelope gp120 outer domain plays a key role in modulating viral phenotype. However, the molecular mechanisms underlying the modulation remain poorly understood.
Masaru Yokoyama +4 more
doaj +1 more source
The V2 domain of HIV gp120 mimics an interaction between CD4 and integrin ⍺4β7.
PLoS Pathogens, 2023 The CD4 receptor, by stabilizing TCR-MHC II interactions, plays a central role in adaptive immunity. It also serves as the HIV docking receptor. The HIV gp120 envelope protein binds directly to CD4.
Donald Van Ryk +17 more
doaj +1 more source
PLoS Pathogens, 2023 Recent HIV-1 vaccine development has centered on "near native" soluble envelope glycoprotein (Env) trimers that are artificially stabilized laterally (between protomers) and apically (between gp120 and gp41).
Tommy Tong +7 more
doaj +1 more source
Resveratrol-decreased hyperalgesia mediated by the P2X receptor in gp120-treated rats
Molecular Pain, 2017 Background Chronic pain is a common symptom in human immunodeficiency virus (HIV)-1 infection/acquired immunodeficiency syndrome patients. The literature shows that the HIV envelope glycoprotein 120 (gp120) can directly cause hyperalgesia by stimulating ...
Bing Wu +13 more
doaj +1 more source
Allosteric modulation of the HIV-1 gp120-gp41 association site by adjacent gp120 variable region 1 (V1) N-glycans linked to neutralization sensitivity. [PDF]
PLoS Pathogens, 2013 The HIV-1 gp120-gp41 complex, which mediates viral fusion and cellular entry, undergoes rapid evolution within its external glycan shield to enable escape from neutralizing antibody (NAb).
Heidi E Drummer +6 more
doaj +1 more source
X4 Human immunodeficiency virus type 1 gp120 promotes human hepatic stellate cell activation and collagen I expression through interactions with CXCR4. [PDF]
PLoS ONE, 2012 Patients coinfected with HIV-1 and HCV develop more rapid liver fibrosis than patients monoinfected with HCV. HIV RNA levels correlate with fibrosis progression implicating HIV directly in the fibrotic process.
Feng Hong +4 more
doaj +1 more source
Comparing Antigenicity and Immunogenicity of Engineered gp120 [PDF]
Journal of Virology, 2005 ABSTRACTWe have engineered monomeric gp120 in such a way as to favorably present the conserved epitope for the broadly neutralizing antibody b12 while lowering the exposure of epitopes recognized by some weakly neutralizing and nonneutralizing antibodies.
Suganya, Selvarajah +5 more
openaire +2 more sources