Results 51 to 60 of about 15,690 (179)
BMC Immunology, 2006 Background One of the major obstacles in the design of an effective vaccine against HIV-1 is the hypervariability of the HIV-1 envelope glycoprotein. Most HIV-1 vaccine candidates have utilized envelope glycoprotein from a single virus isolate, but to ...
Ghorbani Masoud +4 more
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A mechanistic understanding of allosteric immune escape pathways in the HIV-1 envelope glycoprotein. [PDF]
PLoS Computational Biology, 2013 The HIV-1 envelope (Env) spike, which consists of a compact, heterodimeric trimer of the glycoproteins gp120 and gp41, is the target of neutralizing antibodies. However, the high mutation rate of HIV-1 and plasticity of Env facilitates viral evasion from
Anurag Sethi +4 more
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Structural Insights Into Man9 Recognition by the HIV Antibody 2G12 Revealed by Paramagnetic NMR
Advanced Science, Volume 13, Issue 31, 4 June 2026.The HIV gp120 glycoprotein displays Man9 oligomannose structures that are recognized by the neutralizing antibody 2G12. Detailed characterization of the binding epitope in solution is important for immunogen design but remains challenging, since the signals of the terminal mannoses from the three arms of Man9 (D1, D2, and D3) cannot be distinguished in
Adrián Silva‐Díaz +7 more
wiley +1 more source
Transgenic mice expressing HIV-1 envelope protein gp120 in the brain as an animal model in neuroAIDS research [PDF]
Journal of NeuroVirology, 2017 HIV-1 infection causes injury to the central nervous system (CNS) and is often associated with neurocognitive disorders. One model for brain damage seen in AIDS patients is the transgenic (tg) mouse expressing a soluble envelope protein gp120 of HIV-1 LAV in the brain in astrocytes under the control of the promoter of glial fibrillary acidic protein ...
Victoria E. Thaney +6 more
openaire +4 more sources
Human immunodeficiency virus 1 glycoprotein 120 induces endoplasmic reticulum stress in neurons
Cell Death and DiseasePeople living with Human Immunodeficiency Virus (HIV) (PLWH) may develop HIV-associated neurocognitive disorder (HAND) despite the use of antiretroviral therapy.
Christy Agbey +4 more
doaj +1 more source
Protein Science, Volume 35, Issue 6, June 2026.Abstract Membrane fusion between HIV and host cells requires interaction between the N‐terminal and C‐terminal repeat regions (NHR and CHR) of the gp41 envelope subunit. A deep hydrophobic pocket (HP) on the surface of NHR is considered crucial in this interaction.
Daniel Polo‐Megías +9 more
wiley +1 more source
PLoS Biology, 2018 Over half of individuals infected with human immunodeficiency virus (HIV) suffer from HIV-associated neurocognitive disorders (HANDs), yet the molecular mechanisms leading to neuronal dysfunction are poorly understood. Feline immunodeficiency virus (FIV)
Keira Sztukowski +12 more
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Surfactant Protein D modulates HIV infection of both T-cells and dendritic cells.
PLoS ONE, 2013 Surfactant Protein D (SP-D) is an oligomerized C-type lectin molecule with immunomodulatory properties and involvement in lung surfactant homeostasis in the respiratory tract.
Jens Madsen +5 more
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American Journal of Reproductive Immunology, Volume 95, Issue 6, June 2026.ABSTRACT HIV transmission through the female and male reproductive tracts is governed by spatially organized interactions between virions, epithelial barriers, and tissue‐resident immune cells. Imaging approaches have been central to defining these earliest events, progressing from classical histology and immunohistochemistry (IHC) to modern ...
Ann M. Carias +3 more
wiley +1 more source
Helix-A peptide prevents gp120-mediated neuronal loss
Molecular Brain, 2019 Aim The human-immunodeficiency virus (HIV) envelope protein gp120 promotes synaptic damage similar to that observed in people living with HIV who have neurocognitive disorders.
Valeria Avdoshina +4 more
doaj +1 more source