Results 31 to 40 of about 15,684 (181)

Full‐Length Next‐Generation Sequencing of 11 HLA Loci of More Than 1000 Individuals From Clinical Cohorts in East and West Africa

HLA, Volume 108, Issue 1, July 2026.
ABSTRACT HLA loci have been implicated in several diseases, including HIV‐1, from different world populations. It is necessary to characterise HLA allele variation at the population level prior to investigating associations linked to human diseases. In global databases, limited high‐resolution HLA allele types generated by next‐generation sequencing ...
Yvonne V. Rosario, Aviva Geretz, Lakshmi Rani Iyer, Philip K. Ehrenberg, Alýa Tyson, Hannah Kibuuka, Fred Wabwire‐Mangen, Lucas Maganga, Abdulwasiu Tiamiyu, Jonah Maswai, Josphat Kosgei, Frederick Sawe, Gary R. Matyas, Merlin L. Robb, Julie A. Ake, Rasmi Thomas   +15 more
wiley   +1 more source

Specific binding of HIV-1 envelope protein gp120 to the structural membrane proteins ezrin and moesin

Virus Research, 1997
The observation that HIV in vitro can infect CD4- and Gal-C-negative brain cell lines has stimulated this study to identify alternative gp120-binding proteins on brain cells. HIV-1 gp120 binding proteins of the CD4-negative and Gal-C-negative, non-productively infectable human glioblastoma cell line D54 were purified by affinity chromatography over a ...
Hecker, Claudia, Weise, Christoph, Schneider-Schaulies, Jürgen, Holmes, Harvey C, ter Meulen, Volker   +4 more
openaire   +2 more sources

Structural Insights Into Man9 Recognition by the HIV Antibody 2G12 Revealed by Paramagnetic NMR

Advanced Science, Volume 13, Issue 31, 4 June 2026.
The HIV gp120 glycoprotein displays Man9 oligomannose structures that are recognized by the neutralizing antibody 2G12. Detailed characterization of the binding epitope in solution is important for immunogen design but remains challenging, since the signals of the terminal mannoses from the three arms of Man9 (D1, D2, and D3) cannot be distinguished in
Adrián Silva‐Díaz, Paola Oquist‐Phillips, Noelia de la Cruz, Inés Lera‐Lasso, Laura Castañar, Javier Rojo, Javier Ramos‐Soriano, Ángeles Canales   +7 more
wiley   +1 more source

Investigating the role of a conserved hydrophobic pocket of gp41 in the anti‐HIV activity of fusion inhibitors

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Membrane fusion between HIV and host cells requires interaction between the N‐terminal and C‐terminal repeat regions (NHR and CHR) of the gp41 envelope subunit. A deep hydrophobic pocket (HP) on the surface of NHR is considered crucial in this interaction.
Daniel Polo‐Megías, Mario Cano‐Muñoz, Laura Sánchez‐Martínez, Sara Lestani, Christiane Moog, Thomas Decoville, María Carmen Salinas‐García, José Antonio Gavira, Ana Cámara‐Artigas, Francisco Conejero‐Lara   +9 more
wiley   +1 more source

Slit2/Robo4 signaling modulates HIV-1 gp120-induced lymphatic hyperpermeability.

PLoS Pathogens, 2012
Dissemination of HIV in the host involves transit of the virus and virus-infected cells across the lymphatic endothelium. HIV may alter lymphatic endothelial permeability to foster dissemination, but the mechanism is largely unexplored.
Xuefeng Zhang, Jinlong Yu, Paula M Kuzontkoski, Weiquan Zhu, Dean Y Li, Jerome E Groopman   +5 more
doaj   +1 more source

In Silico Identification of Novel Aromatic Compounds as Potential HIV-1 Entry Inhibitors Mimicking Cellular Receptor CD4

Viruses, 2019
Despite recent progress in the development of novel potent HIV-1 entry/fusion inhibitors, there are currently no licensed antiviral drugs based on inhibiting the critical interactions of the HIV-1 envelope gp120 protein with cellular receptor CD4.
Alexander M. Andrianov, Grigory I. Nikolaev, Yuri V. Kornoushenko, Wei Xu, Shibo Jiang, Alexander V. Tuzikov   +5 more
doaj   +1 more source

Functional Mimetics of the HIV-1 CCR5 Co-Receptor Displayed on the Surface of Magnetic Liposomes. [PDF]

PLoS ONE, 2015
Chemokine G protein coupled receptors, principally CCR5 or CXCR4, function as co-receptors for HIV-1 entry into CD4+ T cells. Initial binding of the viral envelope glycoprotein (Env) gp120 subunit to the host CD4 receptor induces a cascade of structural ...
Alona Kuzmina, Karin Vaknin, Garik Gdalevsky, Maria Vyazmensky, Robert S Marks, Ran Taube, Stanislav Engel   +6 more
doaj   +1 more source

The Spatial Biology of HIV Transmission and Infection: Imaging the Female and Male Reproductive Tracts

American Journal of Reproductive Immunology, Volume 95, Issue 6, June 2026.
ABSTRACT HIV transmission through the female and male reproductive tracts is governed by spatially organized interactions between virions, epithelial barriers, and tissue‐resident immune cells. Imaging approaches have been central to defining these earliest events, progressing from classical histology and immunohistochemistry (IHC) to modern ...
Ann M. Carias, Claudia C. Stroupe, Thatiane Russo, Thomas J. Hope   +3 more
wiley   +1 more source

HIV‐1 Envelope Protein gp120 Is Present at High Concentrations in Secondary Lymphoid Organs of Individuals with Chronic HIV‐1 Infection [PDF]

The Journal of Infectious Diseases, 2009
The envelope protein of human immunodeficiency virus type 1 (HIV-1)--glycoprotein 120 (gp120)--has been demonstrated to dysregulate T cell function in vitro. We obtained autopsy tissues from individuals with chronic HIV-1 infection to determine whether there was enough gp120 in lymphoid tissues and/or blood to elicit these effects.
Santosuosso M, Righi E, Lindstrom V, Leblanc PR, Poznansky MC   +4 more
openaire   +3 more sources

Adaptation of the REINVENT neural network architecture to generate potential HIV-1 entry inhibitors

Informatika
Objectives. The main purpose of this work is to adapt the architecture of the REINVENT neural network to generate potential inhibitors of the HIV-1 envelope protein gp120 using in the learning process with reinforcement of molecular docking on GPUs ...
D. A. Varabyeu, A. D. Karpenko, A. V. Tuzikov, A. M. Andrianov   +3 more
doaj   +1 more source