Results 31 to 40 of about 25,017 (220)

Role of the transcription factor E2F1 in CXCR4-mediated neurotoxicity and HIV neuropathology

Neurobiology of Disease, 2007
This study sought to determine the role of the transcription factor E2F1 in CXCR4-mediated neurotoxicity and HIV neuropathology. We studied the effect of the HIV envelope protein gp120 on the expression of E2F1-dependent apoptotic proteins in human and ...
Saori Shimizu, Muhammad Z. Khan, Randi L Hippensteel, Anjum Parkar,, Ramesh Raghupathi, Olimpia Meucci   +5 more
doaj   +1 more source

HIV-1 Envelope Protein gp120 Promotes Proliferation and the Activation of Glycolysis in Glioma Cell [PDF]

Cancers, 2018
Patients infected with human immunodeficiency virus (HIV) are more prone to developing cancers, including glioblastomas (GBMs). The median survival for HIV positive GBM patients is significantly shorter than for those who are uninfected, despite the fact that they receive the same treatments.
Gabriel Valentín-Guillama, Sheila López, Yuriy V. Kucheryavykh, Nataliya E. Chorna, Jose Pérez, Jescelica Ortiz-Rivera, Michael Inyushin, Vladimir Makarov, Aníbal Valentín-Acevedo, Alfredo Quinones-Hinojosa, Nawal Boukli, Lilia Y. Kucheryavykh   +11 more
openaire   +2 more sources

Learning impairment following intracerebral administration of the HIV envelope protein gp120 or a VIP antagonist [PDF]

Brain Research, 1992
The external envelope glycoprotein (gp120) of the human immunodeficiency virus (HIV) has been shown to be toxic to neurons in culture. To further investigate the neurological effects of gp120, the involvement of this protein with the acquisition of spatial discrimination was assessed.
J R, Glowa, L V, Panlilio, D E, Brenneman, I, Gozes, M, Fridkin, J M, Hill   +5 more
openaire   +2 more sources

Human CNS cultures exposed to HIV-1 gp120 reproduce dendritic injuries of HIV-1-associated dementia

Journal of Neuroinflammation, 2004
HIV-1-associated dementia remains a common subacute to chronic central nervous system degeneration in adult and pediatric HIV-1 infected populations.
Hammond Robert R, Walsh Kimberley A, Iskander Sam   +2 more
doaj   +1 more source

Generation and characterization of a bivalent protein boost for future clinical trials: HIV-1 subtypes CR01_AE and B gp120 antigens with a potent adjuvant. [PDF]

PLoS ONE, 2018
The RV144 Phase III clinical trial with ALVAC-HIV prime and AIDSVAX B/E subtypes CRF01_AE (A244) and B (MN) gp120 boost vaccine regime in Thailand provided a foundation for the future development of improved vaccine strategies that may afford protection ...
Yingxia Wen, Hung V Trinh, Christine E Linton, Chiara Tani, Nathalie Norais, DeeAnn Martinez-Guzman, Priyanka Ramesh, Yide Sun, Frank Situ, Selen Karaca-Griffin, Christopher Hamlin, Sayali Onkar, Sai Tian, Susan Hilt, Padma Malyala, Rushit Lodaya, Ning Li, Gillis Otten, Giuseppe Palladino, Kristian Friedrich, Yukti Aggarwal, Celia LaBranche, Ryan Duffy, Xiaoying Shen, Georgia D Tomaras, David C Montefiori, William Fulp, Raphael Gottardo, Brian Burke, Jeffrey B Ulmer, Susan Zolla-Pazner, Hua-Xin Liao, Barton F Haynes, Nelson L Michael, Jerome H Kim, Mangala Rao, Robert J O'Connell, Andrea Carfi, Susan W Barnett   +38 more
doaj   +1 more source

Surfactant protein D binds to human immunodeficiency virus (HIV) envelope protein gp120 and inhibits HIV replication

Journal of General Virology, 2005
The envelope protein (gp120) of human immunodeficiency virus (HIV) contains highly conserved mannosylated oligosaccharides. These glycoconjugates contribute to resistance to antibody neutralization, and binding to cell surface lectins on macrophages and dendritic cells. Mannose-binding lectin (MBL) binds to gp120 and plays a role in defence against the
Meschi, Joseph, Crouch, Erika C, Skolnik, Paul, Yahya, Khabirah, Holmskov, Uffe, Leth-Larsen, Rikke, Tornoe, Ida, Tecle, Tesfaldet, White, Mitchell R, Hartshorn, Kevan L   +9 more
openaire   +3 more sources

HIV-1 gp120 Protein Activates Cyclin-Dependent Kinase 1, a Possible Link to Central Nervous System Cell Death

Viruses, 2022
Human immunodeficiency virus-1 (HIV-1)-associated neurodegenerative disorder (HAND) is frequently reported in HIV-infected individuals. The gp120 envelope viral protein has been implicated in the pathogenesis of HAND in HIV-1-infected patients; however ...
Adonira Saro, Zhaolin Gao, Piniel Alphayo Kambey, Min Li, Jufang Huang   +4 more
doaj   +1 more source

A saposin-lipoprotein nanoparticle system for membrane proteins. [PDF]

, 2016
A limiting factor in membrane protein research is the ability to solubilize and stabilize such proteins. Detergents are used most often for solubilizing membrane proteins, but they are associated with protein instability and poor compatibility with ...
Armache, Jean-Paul, Briggs, John AG, Cheng, Yifan, Flayhan, Ali, Frauenfeld, Jens, Garoff, Henrik, Guettou, Fatma, Jegerschöld, Caroline, Löving, Robin, Löw, Christian, Moberg, Per, Nordlund, Pär, Sonnen, Andreas F-P, Zhu, Lin   +13 more
core   +2 more sources

Super-resolution microscopy reveals specific recruitment of HIV-1 envelope proteins to viral assembly sites dependent on the envelope C-terminal tail [PDF]

, 2013
The inner structural Gag proteins and the envelope (Env) glycoproteins of human immunodeficiency virus (HIV-1) traffic independently to the plasma membrane, where they assemble the nascent virion. HIV-1 carries a relatively low number of glycoproteins in
Heilemann, Mike, Kräusslich, Hans-Georg, Malkusch, Sebastian, Muranyi, Walter, Müller, Barbara   +4 more
core   +14 more sources

Does Antibody Stabilize the Ligand Binding in GP120 of HIV-1 Envelope Protein? Evidence from MD Simulation [PDF]

Molecules, 2021
CD4-mimetic HIV-1 entry inhibitors are small sized molecules which imitate similar conformational flexibility, in gp120, to the CD4 receptor. However, the mechanism of the conformational flexibility instigated by these small sized inhibitors is little known.
Yadav, Shalini, Pandey, Vishnudatt, Tiwari, Rakesh Kumar, Ojha, Rajendra Prasad, Dubey, Kshatresh Dutta   +4 more
openaire   +3 more sources