Results 31 to 40 of about 5,218,351 (211)

Super-resolution microscopy reveals specific recruitment of HIV-1 envelope proteins to viral assembly sites dependent on the envelope C-terminal tail [PDF]

, 2013
The inner structural Gag proteins and the envelope (Env) glycoproteins of human immunodeficiency virus (HIV-1) traffic independently to the plasma membrane, where they assemble the nascent virion. HIV-1 carries a relatively low number of glycoproteins in
Mike Heilemann, Barbara Müller, Walter Muranyi (212637), Malkusch, Sebastian, Müller, Barbara, Hans-Georg Kräusslich (7273), Walter Muranyi, Mike Heilemann (162287), Barbara Müller (212640), Sebastian Malkusch (383895), Muranyi, Walter, Hans-Georg Kräusslich, Kräusslich, Hans-Georg, Sebastian Malkusch, Heilemann, Mike, Malkusch Sebastian, Kräusslich Hans-Georg, Müller Barbara, Muranyi Walter, Heilemann Mike   +19 more
core   +2 more sources

Novel peptides based on HIV-1 gp120 sequence with homology to chemokines inhibit HIV infection in cell culture.

PLoS ONE, 2011
The sequential interaction of the envelope glycoprotein of the human immunodeficiency virus type 1 (HIV-1) with CD4 and certain chemokine coreceptors initiates host cell entry of the virus.
Oleg Chertov, Ning Zhang, Xin Chen, Joost J Oppenheim, Jacek Lubkowski, Connor McGrath, Raymond C Sowder, Bruce J Crise, Anatoli Malyguine, Michele A Kutzler, Amber D Steele, Earl E Henderson, Thomas J Rogers   +12 more
doaj   +1 more source

Assessment of HIV-1 entry inhibitors by MLV/HIV-1 pseudotyped vectors [PDF]

, 2005
Background: Murine leukemia virus (MLV) vector particles can be pseudotyped with a truncated variant of the human immunodeficiency virus type 1 (HIV-1) envelope protein (Env) and selectively target gene transfer to human cells expressing both CD4 and an ...
Sandra Siegert, Barbara S Schnierle, Schnierle Barbara S, Wagner Ralf, Ralf Wagner, Thaler Sonja, Siegert, Sandra, Schnierle, Barbara, Siegert Sandra, Thaler, Sonja, Wagner, Ralf, Sonja Thaler   +11 more
core   +1 more source

Rescue of adult hippocampal neurogenesis in a mouse model of HIV neurologic disease

Neurobiology of Disease, 2011
The prevalence of central nervous system (CNS) neurologic dysfunction associated with human immunodeficiency virus (HIV) infection continues to increase, despite the use of antiretroviral therapy.
Myoung-Hwa Lee, Tongguang Wang, Mi-Hyeon Jang, Joseph Steiner, Norman Haughey, Guo-li Ming, Hongjun Song, Avindra Nath, Arun Venkatesan   +8 more
doaj   +1 more source

HIV-1 inhibitory properties of eCD4-Igmim2 determined using an Env-mediated membrane fusion assay. [PDF]

PLoS ONE, 2018
Human Immunodeficiency Virus-1 (HIV-1) entry is dependent on the envelope glycoprotein (Env) that is present on the virion and facilitates fusion between the envelope and the cellular membrane.
Edward Yang, Matthew R Gardner, Amber S Zhou, Michael Farzan, Ann M Arvin, Stefan L Oliver   +5 more
doaj   +1 more source

Sequence-Conserved and Antibody-Accessible Sites in the V1V2 Domain of HIV-1 gp120 Envelope Protein [PDF]

AIDS Research and Human Retroviruses, 2014
The immune-correlates analysis of the RV144 trial suggested that epitopes targeted by protective antibodies (Abs) reside in the V1V2 domain of gp120. We mapped V1V2 positional sequence variation onto the conserved V1V2 structural fold and showed that while most of the solvent-accessible V1V2 amino acids vary between strains, there are two accessible ...
Shmelkov, Evgeny, Grigoryan, Arsen, Krachmarov, Chavdar, Abagyan, Ruben, Cardozo, Timothy   +4 more
openaire   +4 more sources

Slit2N/Robo1 inhibit HIV-gp120-induced migration and podosome formation in immature dendritic cells by sequestering LSP1 and WASp.

PLoS ONE, 2012
Cell-mediated transmission and dissemination of sexually-acquired human immunodeficiency virus 1 (HIV-1) in the host involves the migration of immature dendritic cells (iDCs).
Anil Prasad, Paula M Kuzontkoski, Ashutosh Shrivastava, Weiquan Zhu, Dean Y Li, Jerome E Groopman   +5 more
doaj   +1 more source

Gp120 on HIV-1 Virions Lacks O-Linked Carbohydrate.

PLoS ONE, 2015
As HIV-1-encoded envelope protein traverses the secretory pathway, it may be modified with N- and O-linked carbohydrate. When the gp120s of HIV-1 NL4-3, HIV-1 YU2, HIV-1 Bal, HIV-1 JRFL, and HIV-1 JRCSF were expressed as secreted proteins, the threonine ...
Elizabeth Stansell, Maria Panico, Kevin Canis, Poh-Choo Pang, Laura Bouché, Daniel Binet, Michael-John O'Connor, Elena Chertova, Julian Bess, Jeffrey D Lifson, Stuart M Haslam, Howard R Morris, Ronald C Desrosiers, Anne Dell   +13 more
doaj   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Mass Spectrometric Characterization of a Discontinuous Epitope of the HIV Envelope Protein HIV-gp120 Recognized by the Human Monoclonal Antibody 1331A [PDF]

The Journal of Immunology, 2000
Abstract The characterization of a discontinuous epitope in the C5 region of the HIV envelope protein HIV-gp120, recognized by 1331A, a human mAb, is reported. Regions involved in affinity binding in the HIV-gp120 molecule were identified by epitope excision/extraction methods followed by matrix assisted laser desorption-time of flight ...
E O, Hochleitner, M K, Gorny, S, Zolla-Pazner, K B, Tomer   +3 more
openaire   +2 more sources