Results 11 to 20 of about 25,017 (220)

Signal peptide of HIV envelope protein impacts glycosylation and antigenicity of gp120 [PDF]

Proceedings of the National Academy of Sciences, 2018
Significance Significant heterogeneity exists in the structure and antigenicity of HIV-1 envelope protein (Env) gp120 due, in part, to various posttranslational modifications. Using glycan and antigenic analysis, we show that the signal peptide (SP) of HIV Env can impact the glycan profile of gp120, which in turn impacts antigenicity of the ...
Yolitz, Jason, Schwing, Catherine, Chang, Julia, Van Ryk, Donald, Nawaz, Fatima, Wei, Danlan, Cicala, Claudia, Arthos, James, Fauci, Anthony S.   +8 more
openaire   +4 more sources

Human immunodeficiency virus envelope protein Gp120 induces proliferation but not apoptosis in osteoblasts at physiologic concentrations. [PDF]

PLoS ONE, 2011
Patients with HIV infection have decreased numbers of osteoblasts, decreased bone mineral density and increased risk of fracture compared to uninfected patients; however, the molecular mechanisms behind these associations remain unclear.
Nathan W Cummins, Anna Klicpera, Amy M Sainski, Gary D Bren, Sundeep Khosla, Jennifer J Westendorf, Andrew D Badley   +6 more
doaj   +1 more source

Surfactant protein D inhibits HIV-1 infection of target cells via interference with gp120-CD4 interaction and modulates pro-inflammatory cytokine production [PDF]

, 2014
© 2014 Pandit et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Al-Mozaini, MA, Gajbhiye, R, Gopal, S, Idicula-Thomas, S, Kishore, U, Kulkarni, V, Madan, T, Pandit, H, Patil, A, Qaseem, AS, Sonawani, A, Warke, H, Yadav, AK   +12 more
core   +11 more sources

Mapping the complete glycoproteome of virion-derived HIV-1 gp120 provides insights into broadly neutralizing antibody binding [PDF]

, 2016
The surface envelope glycoprotein (SU) of Human immunodeficiency virus type 1 (HIV-1), gp120SU plays an essential role in virus binding to target CD4+ T-cells and is a major vaccine target.
Bess, JW, Binet, D, Bouché, L, Canis, K, Chertova, E, Dell, A, Desrosiers, RC, Haslam, SM, Keele, BF, Lifson, JD, Morris, HR, North, SJ, O'Connor, MJ, Pang, PC, Panico, M, Rahman, D   +15 more
core   +1 more source

M‐tropic HIV envelope protein gp120 exhibits a different neuropathological profile than T‐tropic gp120 in rat striatum [PDF]

European Journal of Neuroscience, 2010
AbstractMost early human immunodeficiency virus type 1 (HIV‐1) strains are macrophage (M)‐tropic HIV variants and use the chemokine receptor CCR5 for infection. Neuronal loss and dementia are less severe among individuals infected with M‐tropic strains.
Alessia, Bachis, Maria I, Cruz, Italo, Mocchetti   +2 more
openaire   +2 more sources

Understanding the process of envelope glycoprotein incorporation into virions in simian and feline immunodeficiency viruses [PDF]

, 2014
The lentiviral envelope glycoproteins (Env) mediate virus entry by interacting with specific receptors present at the cell surface, thereby determining viral tropism and pathogenesis.
Affranchino, Jose Luis, Gonzalez, Silvia Adriana   +1 more
core   +4 more sources

X4 Human immunodeficiency virus type 1 gp120 promotes human hepatic stellate cell activation and collagen I expression through interactions with CXCR4. [PDF]

PLoS ONE, 2012
Patients coinfected with HIV-1 and HCV develop more rapid liver fibrosis than patients monoinfected with HCV. HIV RNA levels correlate with fibrosis progression implicating HIV directly in the fibrotic process.
Feng Hong, Yedidya Saiman, Chuanping Si, Arevik Mosoian, Meena B Bansal   +4 more
doaj   +1 more source

HIV-1 inhibitory properties of eCD4-Igmim2 determined using an Env-mediated membrane fusion assay. [PDF]

PLoS ONE, 2018
Human Immunodeficiency Virus-1 (HIV-1) entry is dependent on the envelope glycoprotein (Env) that is present on the virion and facilitates fusion between the envelope and the cellular membrane.
Edward Yang, Matthew R Gardner, Amber S Zhou, Michael Farzan, Ann M Arvin, Stefan L Oliver   +5 more
doaj   +1 more source

Dual-acting stapled peptides target both HIV-1 entry and assembly [PDF]

, 2013
Background: Previously, we reported the conversion of the 12-mer linear and cell-impermeable peptide CAI to a cell-penetrating peptide NYAD-1 by using an i,i + 4 hydrocarbon stapling technique and confirmed its binding to the C-terminal domain (CTD ...
Bhargava, P., Cooper, A., Curreli, F., Debnath, A.K., Freed, E.O., Lee, S., Mehta, M., Mercredi, P.Y., Scacalossi, D., Summers, M.F., Tong, X., Waheed, A.A., Zhang, H.   +12 more
core   +2 more sources

Novel peptides based on HIV-1 gp120 sequence with homology to chemokines inhibit HIV infection in cell culture.

PLoS ONE, 2011
The sequential interaction of the envelope glycoprotein of the human immunodeficiency virus type 1 (HIV-1) with CD4 and certain chemokine coreceptors initiates host cell entry of the virus.
Oleg Chertov, Ning Zhang, Xin Chen, Joost J Oppenheim, Jacek Lubkowski, Connor McGrath, Raymond C Sowder, Bruce J Crise, Anatoli Malyguine, Michele A Kutzler, Amber D Steele, Earl E Henderson, Thomas J Rogers   +12 more
doaj   +1 more source