Results 11 to 20 of about 5,218,351 (211)

PET imaging of HIV-1 envelope protein gp120 using 18F-labeled nanobodies

iScience
Summary: Radiolabeled antibodies against the HIV-1 envelope protein, gp120, have been previously tested in animal models and in people with HIV (PWH). Nanobodies offer advantages over antibodies, including smaller size and faster clearance, which allow ...
Neysha Martinez-Orengo, Swati Shah, Jianhao Lai, Falguni Basuli, Anna Lyndaker, Mitchell L. Turner, Morteza Peiravi, Suman Sourabh, Kevon Sampson, Peng Zhang, Rolf E. Swenson, Paolo Lusso, Frank Maldarelli, Avindra Nath, Chuen-Yen Lau, Dima A. Hammoud   +15 more
doaj   +3 more sources

Surfactant protein D binds to human immunodeficiency virus (HIV) envelope protein gp120 and inhibits HIV replication

Journal of General Virology, 2005
The envelope protein (gp120) of human immunodeficiency virus (HIV) contains highly conserved mannosylated oligosaccharides. These glycoconjugates contribute to resistance to antibody neutralization, and binding to cell surface lectins on macrophages and dendritic cells.
Meschi, Joseph, Crouch, Erika C, Skolnik, Paul, Yahya, Khabirah, Holmskov, Uffe, Leth-Larsen, Rikke, Tornoe, Ida, Tecle, Tesfaldet, White, Mitchell R, Hartshorn, Kevan L   +9 more
openaire   +3 more sources

Effect of Glycosylation on an Immunodominant Region in the V1V2 Variable Domain of the HIV-1 Envelope gp120 Protein. [PDF]

PLoS Computational Biology, 2016
Heavy glycosylation of the envelope (Env) surface subunit, gp120, is a key adaptation of HIV-1; however, the precise effects of glycosylation on the folding, conformation and dynamics of this protein are poorly understood. Here we explore the patterns of
Jianhui Tian, Cesar A López, Cynthia A Derdeyn, Morris S Jones, Abraham Pinter, Bette Korber, S Gnanakaran   +6 more
doaj   +4 more sources

Peripheral nerve exposure to HIV viral envelope protein gp120 induces neuropathic pain and spinal gliosis

Journal of Neuroimmunology, 2001
Painful sensory neuropathy is a common and debilitating consequence of human immunodeficiency virus (HIV). The underlying causes of neuropathic pain are most likely not due to direct infection of the nervous system by active virus. The goal of this study was to determine whether epineural exposure to the HIV-1 envelope protein gp120 could lead to ...
U, Herzberg, J, Sagen
openaire   +3 more sources

Role of the HIV-1 GP120 conserved domain 5 in envelope protein maturation and viral entry.

, 2007
Role of the HIV-1 GP120 conserved domain 5 in envelope protein maturation and viral ...
Jayita. Sen (7987124)
core   +5 more sources

Surfactant protein D inhibits HIV-1 infection of target cells via interference with gp120-CD4 interaction and modulates pro-inflammatory cytokine production [PDF]

, 2014
© 2014 Pandit et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Al-Mozaini, MA, Pandit Hrishikesh, Yadav Ajit Kumar, Gopal, S, Idicula-Thomas, S, Uday Kishore (504246), Al-Mozaini Maha Ahmed, Vijay Kulkarni, Himangi Warke, Gopal Sandhya, Asif S Qaseem, Sonawani, A, Kulkarni, V, Warke Himangi, Hrishikesh Pandit, Patil, A, Himangi Warke (504243), Idicula-Thomas Susan, Anushree Patil (600836), Gajbhiye, R, Yadav, AK, Sandhya Gopal (600833), Kulkarni Vijay, Archana Sonawani (413679), Warke, H, Susan Idicula-Thomas, Taruna Madan, Sonawani Archana, Asif S. Qaseem, Maha Ahmed Al-Mozaini, Archana Sonawani, Hrishikesh Pandit (504240), Ajit Kumar Yadav (600834), Rahul Gajbhiye (600837), Qaseem, AS, Madan, T, Madan Taruna, Sandhya Gopal, Ajit Kumar Yadav, Qaseem Asif S., Gajbhiye Rahul, Rahul Gajbhiye, Patil Anushree, Pandit, H, Asif S. Qaseem (600835), Kishore Uday, Anushree Patil, Vijay Kulkarni (600838), Maha Ahmed Al-Mozaini (600839), Kishore, U, Taruna Madan (504241), Susan Idicula-Thomas (318974), Uday Kishore   +52 more
core   +2 more sources

HIV-gp120

, 2021
Deciphering the glycosylation of viral envelope (Env) glycoprotein is critical for evaluating viral invasion and the host’s immune response, and developing preventive vaccines and antiviral drugs.
Yong Zhang (9437864)
core   +1 more source

Induction of cytolytic T lymphocytes directed towards the V3 loop of the human immunodeficiency virus type 1 external glycoprotein gp120 by p55gag/V3 chimeric vaccinia viruses [PDF]

, 1993
T cell-mediated cytotoxicity may play an important role in controlling infection by human immunodeficiency virus (HIV). In order to study the ability of rationally designed antigens to induce cytolytic T lymphocytes (CTLs) we replaced stretches of 30 to ...
Deml, Ludwig, Böltz, T., Wagner, Ralf, Modrow, Susanne, Wolf, Hans J.   +4 more
core   +1 more source

Novel Cell type-specific aptamer-siRNA delivery system for HIV-1 therapy [PDF]

, 2007
The successful use of small interfering RNAs (siRNAs) for therapeutic purposes requires safe and efficient delivery to specific cells and tissues. Here we demonstrate cell type-specific delivery of anti-HIV siRNAs via fusion to an anti-gp120 aptamer. The
Haitang Li, John Zaia, John Rossi, Jiehua Zhou, Shirley Li   +4 more
core   +1 more source

Learning impairment following intracerebral administration of the HIV envelope protein gp120 or a VIP antagonist [PDF]

Brain Research, 1992
The external envelope glycoprotein (gp120) of the human immunodeficiency virus (HIV) has been shown to be toxic to neurons in culture. To further investigate the neurological effects of gp120, the involvement of this protein with the acquisition of spatial discrimination was assessed.
Glowa, John R., Panlilio, Leigh V., Brenneman, Douglas E., Gozes, Illana, Fridkin, Mati, Hill, Joanna M.   +5 more
openaire   +3 more sources