Results 21 to 30 of about 5,218,351 (211)

Positive In Vivo Selection of the HIV‐1 Envelope Protein gp120 Occurs at Surface‐Exposed Regions [PDF]

The Journal of Infectious Diseases, 2007
The rapid evolution of human immunodeficiency virus (HIV) envelope represents a major challenge to vaccine and drug development, particularly because the underlying mechanisms are not completely understood. To explore whether distinct patterns of positive selection within the envelope glycoprotein (gp) 120 exist and are associated with functionally ...
Joos, B, Fischer, M, Schweizer, A, Kuster, H, Böni, J, Wong, J K, Weber, R, Trkola, A, Gunthard, H F   +8 more
openaire   +4 more sources

Effect of chloroquine on reducing HIV-1 replication in vitro and the DC-SIGN mediated transfer of virus to CD4⁺ T-lymphocytes

Retrovirology, 2007
Background Chloroquine (CQ) has been shown to inhibit HIV-1 replication in vitro as well as in vivo and has been proposed to alter the glycosylation pattern of the gp120 envelope.
Paxton William A, Pollakis Georgios, Baan Elly, Naarding Marloes A   +3 more
doaj   +1 more source

M‐tropic HIV envelope protein gp120 exhibits a different neuropathological profile than T‐tropic gp120 in rat striatum [PDF]

European Journal of Neuroscience, 2010
AbstractMost early human immunodeficiency virus type 1 (HIV‐1) strains are macrophage (M)‐tropic HIV variants and use the chemokine receptor CCR5 for infection. Neuronal loss and dementia are less severe among individuals infected with M‐tropic strains.
Alessia, Bachis, Maria I, Cruz, Italo, Mocchetti   +2 more
openaire   +2 more sources

Entry Inhibitors Directed Towards Glycoprotein gp120: An Overview on a Promising Target for HIV-1 Therapy [PDF]

, 2013
In spite of the unquestionable positive impact of HAART in the treatment of HIV infection, the discovery and development of novel agents directed towards other targets of the replicative cycle of the virus that differ from those targeted by the ...
Flores, Aida, Quesada, Ernesto, Quesada del Sol, Ernesto, Flores Aguilar-Amat, Aída   +3 more
core   +2 more sources

Human CNS cultures exposed to HIV-1 gp120 reproduce dendritic injuries of HIV-1-associated dementia

Journal of Neuroinflammation, 2004
HIV-1-associated dementia remains a common subacute to chronic central nervous system degeneration in adult and pediatric HIV-1 infected populations.
Hammond Robert R, Walsh Kimberley A, Iskander Sam   +2 more
doaj   +1 more source

HIV-1 gp120 Protein Activates Cyclin-Dependent Kinase 1, a Possible Link to Central Nervous System Cell Death

Viruses, 2022
Human immunodeficiency virus-1 (HIV-1)-associated neurodegenerative disorder (HAND) is frequently reported in HIV-infected individuals. The gp120 envelope viral protein has been implicated in the pathogenesis of HAND in HIV-1-infected patients; however ...
Adonira Saro, Zhaolin Gao, Piniel Alphayo Kambey, Min Li, Jufang Huang   +4 more
doaj   +1 more source

Genetic and immunological characterization of new subtype G envelope expressing HIV-1 pseudoviruses [PDF]

, 2014
Includes bibliographical references.One of the greatest challenges for the development of an effective HIV-1 vaccine is the high genetic diversity of this pathogen and the complex escape mechanisms employed by the envelope gp120 and gp41 glycoprotein ...
Essomba, Rene Ghislain
core   +1 more source

Binding of HIV-1 gp120 to DC-SIGN promotes ASK-1-dependent activation-induced apoptosis of human dendritic cells.

PLoS Pathogens, 2013
During disease progression to AIDS, HIV-1 infected individuals become increasingly immunosuppressed and susceptible to opportunistic infections. It has also been demonstrated that multiple subsets of dendritic cells (DC), including DC-SIGN⁺ cells, become
Yongxiong Chen, Shiuh-Lin Hwang, Vera S F Chan, Nancy P Y Chung, Shu-Rong Wang, Zhongye Li, Jing Ma, Chia-Wei Lin, Ya-Ju Hsieh, Kao-Ping Chang, Sui-Sum Kung, Yi-Chia Wu, Cheng-Wei Chu, Hsiao-Ting Tai, George F Gao, Bojian Zheng, Kazunari K Yokoyama, Jonathan M Austyn, Chen-Lung S Lin   +18 more
doaj   +1 more source

Amelioration of Neurotoxic Effects of HIV Envelope Protein gp120 by Fibroblast Growth Factor: A Strategy for Neuroprotection [PDF]

Journal of Neuropathology & Experimental Neurology, 2001
Approximately two thirds of patients with human immunodeficiency virus encephalitis (HIVE) show cognitive impairment and neurodegeneration, while one third are cognitively unimpaired and their neuronal populations are preserved. Thus, it is possible that these individuals might have the capacity to produce neurotrophic factors capable of protecting ...
Everall, I P, Trillo-Pazos, G, Bell, C, Mallory, M, Sanders, V, Masliah, E   +5 more
openaire   +2 more sources

Coupling of HIV-1 gp120-derived Core Protein to Paramagnetic Beads and Adsorption Assays

Bio-Protocol, 2015
Analysis of the functional activity in polyclonal serum following immunization of a complex protein or glycoprotein immunogen is a very important but tedious process.
Jidnyasa Ingale, Richard Wyatt
doaj   +1 more source