Results 71 to 80 of about 15,684 (181)

Preliminary evaluation of KYNA ameliorates neuronal pyroptosis induced by HIV-1 gp120

International Journal of Infectious Diseases
Backgrounds: HIV-associated neurocognitive disorders (HAND) are the common complications in the central nervous system (CNS), mainly causing HIV dementia and leading to serious social economic load.
Dr Xuefeng Gao, Mr Wenchang Wang, Ms Yanjun Zhang, Ms Miaochun Chen, Prof Min Long, Mr. Xuefeng Gao   +5 more
doaj   +1 more source

The HIV-1 envelope protein gp120 is captured and displayed for B cell recognition by SIGN-R1+ lymph node macrophages

eLife, 2015
The HIV-1 envelope protein gp120 is both the target of neutralizing antibodies and a major focus of vaccine efforts; however how it is delivered to B cells to elicit an antibody response is unknown.
Chung Park, James Arthos, Claudia Cicala, John H Kehrl   +3 more
doaj   +1 more source

Recent Developments in HIV Antivirals: The Prospect of Prophylactic Drugs to Change the Pandemic

Microbial Biotechnology, Volume 19, Issue 2, February 2026.
Replication cycle of HIV‐1. The scheme provides an overview from virus entry over reverse transcription of viral RNA into viral DNA, provirus DNA integration into the host genome, genome expression by transcription and translation, proteolytic processing of the viral polyproteins, viral maturation to viral release from the cell. The various targets for
Harald Brüssow
wiley   +1 more source

Chimera X Interface to Enhance Understanding in Biochemistry and Immunology

Biochemistry and Molecular Biology Education, Volume 54, Issue 1, Page 92-102, January/February 2026.
ABSTRACT Proteins are essential in biological systems, acting in transport, catalysis, and immune defense processes. However, these biomolecules' structural and functional complexity makes teaching and understanding these topics challenging. To address this difficulty, this study aimed to develop tutorials that facilitate learning and teaching about ...
Dalpiaz Giovana, Krohn Muriel Schiling, Groehs Eduarda, Anjos André da Silva, Meireles R. Mariana   +4 more
wiley   +1 more source

Atomic force microscopy fishing and mass spectrometry identification of gp120 on immobilized aptamers

International Journal of Nanomedicine, 2014
Yuri D Ivanov,1 Natalia S Bukharina,1 Tatyana O Pleshakova,1 Pavel A Frantsuzov,1 Elena Yu Andreeva,1 Anna L Kaysheva,1,2 Victor G Zgoda,1 Alexander A Izotov,1 Tatyana I Pavlova,1 Vadim S Ziborov,1 Sergey P Radko,1 Sergei A Moshkovskii,1 Alexander I ...
Ivanov YD, Bukharina NS, Pleshakova TO, Frantsuzov PA, Andreeva EY, Kaysheva AL, Zgoda VG, Izotov AA, Pavlova TI, Ziborov VS, Radko SP, Moshkovskii SA, Archakov AI   +12 more
doaj  

Tyrosine-sulfated V2 peptides inhibit HIV-1 infection via coreceptor mimicry

EBioMedicine, 2016
Tyrosine sulfation is a post-translational modification that facilitates protein-protein interaction. Two sulfated tyrosines (Tys173 and Tys177) were recently identified within the second variable (V2) loop of the major HIV-1 envelope glycoprotein, gp120,
Raffaello Cimbro, Francis C. Peterson, Qingbo Liu, Christina Guzzo, Peng Zhang, Huiyi Miao, Donald Van Ryk, Xavier Ambroggio, Darrell E. Hurt, Luca De Gioia, Brian F. Volkman, Michael A. Dolan, Paolo Lusso   +12 more
doaj   +1 more source

Search for antiviral functions of potentially protective antibodies against V2 region of HIV-1

Human Vaccines & Immunotherapeutics, 2020
In the only successful RV144 vaccine trial to date, high levels of antibodies (Abs) against the V2 region of the virus envelope protein gp120 correlated with reduced HIV-1 infection.
Miroslaw K. Gorny
doaj   +1 more source

Generation and Characterization of a Bivalent HIV-1 Subtype C gp120 Protein Boost for Proof-of-Concept HIV Vaccine Efficacy Trials in Southern Africa.

PLoS ONE, 2016
The viral envelope glycoprotein (Env) is the major target for antibody (Ab)-mediated vaccine development against the Human Immunodeficiency Virus type 1 (HIV-1).
Carlo Zambonelli, Antu K Dey, Susan Hilt, Samuel Stephenson, Eden P Go, Daniel F Clark, Mark Wininger, Celia Labranche, David Montefiori, Hua-Xin Liao, Ronald I Swanstrom, Heather Desaire, Barton F Haynes, Andrea Carfi, Susan W Barnett   +14 more
doaj   +1 more source

Immunogenicity and protection mediated by dmLT and alum adjuvants for an HIV-1 vaccine

Frontiers in Immunology
The development of an effective HIV-1 vaccine is of paramount importance to global health. Here, we compared the influence of two adjuvants, Escherichia coli double-mutant heat-labile toxin (dmLT) and alum, on the protective immunity induced by a ...
Kasey Stokdyk, Kasey Stokdyk, Anusmita Sahoo, Anusmita Sahoo, Sailaja Gangadhara, Sailaja Gangadhara, LaTonya D. Williams, LaTonya D. Williams, Tiffany M. Styles, Tiffany M. Styles, Caleb A. Hellman, Caleb A. Hellman, Lu Zhang, Lu Zhang, Ahmad J. Odeh, Ahmad J. Odeh, Shelby Flaherty, Xiaoying Shen, Mohammad Arif Rahman, Elizabeth B. Norton, Genoveffa Franchini, David Montefiori, Pamela A. Kozlowski, Georgia D. Tomaras, Georgia D. Tomaras, Rama Rao Amara, Rama Rao Amara   +26 more
doaj   +1 more source

Reversal of Cognitive Impairment in gp120 Transgenic Mice by the Removal of the p75 Neurotrophin Receptor

Frontiers in Cellular Neuroscience, 2019
Activation of the p75 neurotrophin receptor (p75NTR), by the proneurotrophin brain-derived neurotrophic factor (proBDNF), triggers loss of synapses and promotes neuronal death.
Andrew Speidell, Gino Paolo Asuni, Valeria Avdoshina, Serena Scognamiglio, Patrick Forcelli, Italo Mocchetti   +5 more
doaj   +1 more source