Results 71 to 80 of about 15,690 (179)

Mutant CD4 Molecules with Improved Binding to HIV Envelope Protein gp120 Selected by Phage Display

Virology, 1997
Phage-display methodology has been used to select variant CD4 proteins exhibiting increased binding to the surface envelope glycoprotein, gp120, of Human Immunodeficiency Virus Type-1. To facilitate the selection, a library of mutant CD4 proteins was constructed by cloning a PCR-generated error prone population of the first two domains of CD4 into the ...
Krykbaev, Rustem, McKeating, Jane, Jones, Ian   +2 more
openaire   +2 more sources

HIV-1 gp120 protein downregulates Nef induced IL-6 release in immature dentritic cells through interplay of DC-SIGN.

PLoS ONE, 2013
HIV-1 replication is a tightly controlled mechanism which demands the interplay of host as well as viral factors. Both gp120 (envelope glycoprotein) and Nef (regulatory protein) have been correlated with the development of AIDS disease in independent ...
Roni Sarkar, Debashis Mitra, Sekhar Chakrabarti   +2 more
doaj   +1 more source

Molecular evolution of HIV-1 CRF01_AE Env in Thai patients. [PDF]

PLoS ONE, 2011
BACKGROUND: The envelope glycoproteins (Env), gp120 and gp41, are the most variable proteins of human immunodeficiency virus type 1 (HIV-1), and are the major targets of humoral immune responses against HIV-1.
Samatchaya Boonchawalit, Duangrat Jullaksorn, Jiraporn Uttiyoung, Amara Yowang, Nongkran Krathong, Sununta Chautrakul, Akifumi Yamashita, Kazuyoshi Ikuta, Amornsak Roobsoong, Sangkom Kanitvittaya, Pathom Sawanpanyalert, Masanori Kameoka   +11 more
doaj   +1 more source

Immune non‐response despite effective antiretroviral therapy in people living with HIV: A review of potential mechanisms, biomarkers and therapeutic approaches

HIV Medicine, Volume 27, Issue 4, Page 498-512, April 2026.
Abstract Introduction A proportion of people living with HIV (PLWH) fail to restore their CD4 count or their CD4/CD8 ratio despite effective antiretroviral therapy (ART). PLWH with immune non‐response (INR) are at a higher risk of both AIDS and non‐AIDS events. The underlying mechanisms of INR remain unclear.
Charlotte Silvestre, Antoine Gross, Alain Makinson   +2 more
wiley   +1 more source

HIV-1 Envelope Induces Memory B Cell Responses That Correlate with Plasma Antibody Levels after Envelope gp120 Protein Vaccination or HIV-1 Infection [PDF]

The Journal of Immunology, 2009
Abstract Successful vaccines (i.e., tetanus and diphtheria) can induce long-lived Ab levels that are maintained by bone marrow plasma cells and plasma Ab levels do not correlate with numbers of blood memory B cells. Destruction of CD4+ T cells early in HIV-1 acute infection may result in insufficient induction of neutralizing Ab ...
Mattia, Bonsignori, M Anthony, Moody, Robert J, Parks, T Matt, Holl, Garnett, Kelsoe, Charles B, Hicks, Nathan, Vandergrift, Georgia D, Tomaras, Barton F, Haynes   +8 more
openaire   +2 more sources

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, Volume 36, Issue 26, 30 March 2026.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

Coupling of HIV-1 gp120-derived Core Protein to Paramagnetic Beads and Adsorption Assays

Bio-Protocol, 2015
Analysis of the functional activity in polyclonal serum following immunization of a complex protein or glycoprotein immunogen is a very important but tedious process.
Jidnyasa Ingale, Richard Wyatt
doaj   +1 more source

Theoretical Insights Into the Viral Protein–Metal Interaction Mechanisms for Antiviral Applications

ChemistryEurope, Volume 4, Issue 3, March 2026.
The atomic‐level understanding of the metal–protein interactions is still unclear to further improve the performance of noble metals in protein modifications. This work supplies critical theoretical insights from the atomic level to demonstrate the interaction behaviors between selective SARS‐CoV‐2 Spike protein fragments and Ag/Au.
Qiuyang Lu, Mingzi Sun, Lu Lu, Tong Wu, Zikang Li, Baian Chen, Ziqi Zhou, Shipeng Liang, Hon Ho Wong, Cheuk Hei Chan, Bolong Huang   +10 more
wiley   +1 more source

HIV-1 gp120 mannoses induce immunosuppressive responses from dendritic cells.

PLoS Pathogens, 2007
The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp120 is a vaccine immunogen that can signal via several cell surface receptors.
Meimei Shan, Per Johan Klasse, Kaustuv Banerjee, Antu K Dey, Sai Prasad N Iyer, Robert Dionisio, Dustin Charles, Lila Campbell-Gardener, William C Olson, Rogier W Sanders, John P Moore   +10 more
doaj   +1 more source

Preliminary evaluation of KYNA ameliorates neuronal pyroptosis induced by HIV-1 gp120

International Journal of Infectious Diseases
Backgrounds: HIV-associated neurocognitive disorders (HAND) are the common complications in the central nervous system (CNS), mainly causing HIV dementia and leading to serious social economic load.
Dr Xuefeng Gao, Mr Wenchang Wang, Ms Yanjun Zhang, Ms Miaochun Chen, Prof Min Long, Mr. Xuefeng Gao   +5 more
doaj   +1 more source