Results 71 to 80 of about 25,017 (220)

Adaptation of the REINVENT neural network architecture to generate potential HIV-1 entry inhibitors

Informatika
Objectives. The main purpose of this work is to adapt the architecture of the REINVENT neural network to generate potential inhibitors of the HIV-1 envelope protein gp120 using in the learning process with reinforcement of molecular docking on GPUs ...
D. A. Varabyeu, A. D. Karpenko, A. V. Tuzikov, A. M. Andrianov   +3 more
doaj   +1 more source

Immunogenicity of a polyvalent HIV-1 candidate vaccine based on fourteen wild type gp120 proteins in golden hamsters

BMC Immunology, 2006
Background One of the major obstacles in the design of an effective vaccine against HIV-1 is the hypervariability of the HIV-1 envelope glycoprotein. Most HIV-1 vaccine candidates have utilized envelope glycoprotein from a single virus isolate, but to ...
Ghorbani Masoud, Anderson David E, Azizi Ali, Gee Katrina, Diaz-Mitoma Francisco   +4 more
doaj   +1 more source

A mechanistic understanding of allosteric immune escape pathways in the HIV-1 envelope glycoprotein. [PDF]

PLoS Computational Biology, 2013
The HIV-1 envelope (Env) spike, which consists of a compact, heterodimeric trimer of the glycoproteins gp120 and gp41, is the target of neutralizing antibodies. However, the high mutation rate of HIV-1 and plasticity of Env facilitates viral evasion from
Anurag Sethi, Jianhui Tian, Cynthia A Derdeyn, Bette Korber, S Gnanakaran   +4 more
doaj   +1 more source

Surfactant Protein D modulates HIV infection of both T-cells and dendritic cells.

PLoS ONE, 2013
Surfactant Protein D (SP-D) is an oligomerized C-type lectin molecule with immunomodulatory properties and involvement in lung surfactant homeostasis in the respiratory tract.
Jens Madsen, Gaurav D Gaiha, Nades Palaniyar, Tao Dong, Daniel A Mitchell, Howard W Clark   +5 more
doaj   +1 more source

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, Volume 36, Issue 26, 30 March 2026.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

HIV induces synaptic hyperexcitation via cGMP-dependent protein kinase II activation in the FIV infection model.

PLoS Biology, 2018
Over half of individuals infected with human immunodeficiency virus (HIV) suffer from HIV-associated neurocognitive disorders (HANDs), yet the molecular mechanisms leading to neuronal dysfunction are poorly understood. Feline immunodeficiency virus (FIV)
Keira Sztukowski, Kaila Nip, Paige N Ostwald, Matheus F Sathler, Julianna L Sun, Jiayi Shou, Emily T Jorgensen, Travis E Brown, John H Elder, Craig Miller, Franz Hofmann, Sue VandeWoude, Seonil Kim   +12 more
doaj   +1 more source

Theoretical Insights Into the Viral Protein–Metal Interaction Mechanisms for Antiviral Applications

ChemistryEurope, Volume 4, Issue 3, March 2026.
The atomic‐level understanding of the metal–protein interactions is still unclear to further improve the performance of noble metals in protein modifications. This work supplies critical theoretical insights from the atomic level to demonstrate the interaction behaviors between selective SARS‐CoV‐2 Spike protein fragments and Ag/Au.
Qiuyang Lu, Mingzi Sun, Lu Lu, Tong Wu, Zikang Li, Baian Chen, Ziqi Zhou, Shipeng Liang, Hon Ho Wong, Cheuk Hei Chan, Bolong Huang   +10 more
wiley   +1 more source

Helix-A peptide prevents gp120-mediated neuronal loss

Molecular Brain, 2019
Aim The human-immunodeficiency virus (HIV) envelope protein gp120 promotes synaptic damage similar to that observed in people living with HIV who have neurocognitive disorders.
Valeria Avdoshina, Francesca Taraballi, Ennio Tasciotti, Aykut Üren, Italo Mocchetti   +4 more
doaj   +1 more source

Broadly binding and functional antibodies and persisting memory B cells elicited by HIV vaccine PDPHV

npj Vaccines, 2022
Since publishing our original reports on the safety and immunogenicity of a polyvalent DNA prime-protein boost HIV vaccine (PDPHV) which elicited high titer antibody responses with broad specificity, neutralizing activities to multiple HIV-1 subtypes, as
Shixia Wang, Nicole L. Yates, Justin Pollara, Yegor Voronin, Sherry Stanfield-Oakley, Dong Han, Guangnan Hu, Wei Li, Guido Ferrari, Georgia D. Tomaras, Shan Lu   +10 more
doaj   +1 more source

Rectal Microbiome Composition Correlates with Humoral Immunity to HIV-1 in Vaccinated Rhesus Macaques. [PDF]

, 2019
The microbiome is an integral and dynamic component of the host and is emerging as a critical determinant of immune responses; however, its influence on vaccine immunogenicity is largely not well understood.
Dinasarapu, Ashok R, Durbin-Johnson, Blythe P, Elizaldi, Sonny R, Iyer, Smita S, Kozlowski, Pamela A, Raeman, Reben, Rolston, Matthew, Settles, Matthew, Verma, Anil, Walter, Korey A   +9 more
core   +1 more source