Results 81 to 90 of about 15,690 (179)

The HIV-1 envelope protein gp120 is captured and displayed for B cell recognition by SIGN-R1+ lymph node macrophages

eLife, 2015
The HIV-1 envelope protein gp120 is both the target of neutralizing antibodies and a major focus of vaccine efforts; however how it is delivered to B cells to elicit an antibody response is unknown.
Chung Park, James Arthos, Claudia Cicala, John H Kehrl   +3 more
doaj   +1 more source

Exploring the impact of baseline and on‐treatment variables on durability of responses to fostemsavir through weeks 96 and 192 in the phase 3 BRIGHTE study

HIV Medicine, Volume 27, Issue 3, Page 386-396, March 2026.
Abstract Objectives The gp120‐directed attachment inhibitor fostemsavir was effective in people with multidrug‐resistant (MDR) HIV‐1 in the BRIGHTE study. Understanding factors associated with virologic response can help clinicians optimize treatment and identify individuals for fostemsavir‐based regimens.
M. Gartland, X. Wang, Q. Liao, B. Li, F. Du, M. Krystal, A. R. Tenorio, A. Pierce, J. R. Castillo‐Mancilla   +8 more
wiley   +1 more source

Atomic force microscopy fishing and mass spectrometry identification of gp120 on immobilized aptamers

International Journal of Nanomedicine, 2014
Yuri D Ivanov,1 Natalia S Bukharina,1 Tatyana O Pleshakova,1 Pavel A Frantsuzov,1 Elena Yu Andreeva,1 Anna L Kaysheva,1,2 Victor G Zgoda,1 Alexander A Izotov,1 Tatyana I Pavlova,1 Vadim S Ziborov,1 Sergey P Radko,1 Sergei A Moshkovskii,1 Alexander I ...
Ivanov YD, Bukharina NS, Pleshakova TO, Frantsuzov PA, Andreeva EY, Kaysheva AL, Zgoda VG, Izotov AA, Pavlova TI, Ziborov VS, Radko SP, Moshkovskii SA, Archakov AI   +12 more
doaj  

Search for antiviral functions of potentially protective antibodies against V2 region of HIV-1

Human Vaccines & Immunotherapeutics, 2020
In the only successful RV144 vaccine trial to date, high levels of antibodies (Abs) against the V2 region of the virus envelope protein gp120 correlated with reduced HIV-1 infection.
Miroslaw K. Gorny
doaj   +1 more source

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, Volume 15, Issue 6, 9 February 2026.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

Tyrosine-sulfated V2 peptides inhibit HIV-1 infection via coreceptor mimicry

EBioMedicine, 2016
Tyrosine sulfation is a post-translational modification that facilitates protein-protein interaction. Two sulfated tyrosines (Tys173 and Tys177) were recently identified within the second variable (V2) loop of the major HIV-1 envelope glycoprotein, gp120,
Raffaello Cimbro, Francis C. Peterson, Qingbo Liu, Christina Guzzo, Peng Zhang, Huiyi Miao, Donald Van Ryk, Xavier Ambroggio, Darrell E. Hurt, Luca De Gioia, Brian F. Volkman, Michael A. Dolan, Paolo Lusso   +12 more
doaj   +1 more source

Generation and Characterization of a Bivalent HIV-1 Subtype C gp120 Protein Boost for Proof-of-Concept HIV Vaccine Efficacy Trials in Southern Africa.

PLoS ONE, 2016
The viral envelope glycoprotein (Env) is the major target for antibody (Ab)-mediated vaccine development against the Human Immunodeficiency Virus type 1 (HIV-1).
Carlo Zambonelli, Antu K Dey, Susan Hilt, Samuel Stephenson, Eden P Go, Daniel F Clark, Mark Wininger, Celia Labranche, David Montefiori, Hua-Xin Liao, Ronald I Swanstrom, Heather Desaire, Barton F Haynes, Andrea Carfi, Susan W Barnett   +14 more
doaj   +1 more source

Reversal of Cognitive Impairment in gp120 Transgenic Mice by the Removal of the p75 Neurotrophin Receptor

Frontiers in Cellular Neuroscience, 2019
Activation of the p75 neurotrophin receptor (p75NTR), by the proneurotrophin brain-derived neurotrophic factor (proBDNF), triggers loss of synapses and promotes neuronal death.
Andrew Speidell, Gino Paolo Asuni, Valeria Avdoshina, Serena Scognamiglio, Patrick Forcelli, Italo Mocchetti   +5 more
doaj   +1 more source

Immunogenicity and protection mediated by dmLT and alum adjuvants for an HIV-1 vaccine

Frontiers in Immunology
The development of an effective HIV-1 vaccine is of paramount importance to global health. Here, we compared the influence of two adjuvants, Escherichia coli double-mutant heat-labile toxin (dmLT) and alum, on the protective immunity induced by a ...
Kasey Stokdyk, Kasey Stokdyk, Anusmita Sahoo, Anusmita Sahoo, Sailaja Gangadhara, Sailaja Gangadhara, LaTonya D. Williams, LaTonya D. Williams, Tiffany M. Styles, Tiffany M. Styles, Caleb A. Hellman, Caleb A. Hellman, Lu Zhang, Lu Zhang, Ahmad J. Odeh, Ahmad J. Odeh, Shelby Flaherty, Xiaoying Shen, Mohammad Arif Rahman, Elizabeth B. Norton, Genoveffa Franchini, David Montefiori, Pamela A. Kozlowski, Georgia D. Tomaras, Georgia D. Tomaras, Rama Rao Amara, Rama Rao Amara   +26 more
doaj   +1 more source

Signal peptide exchange alters HIV-1 envelope antigenicity and immunogenicity

Frontiers in Immunology
IntroductionHIV-1 envelope (Env) is the key target for antibodies (Abs) against the virus and thus an important HIV-1 vaccine component. Env is synthesized from a gp160 precursor with a signal peptide (SP) at its N-terminus.
Chitra Upadhyay, Priyanka Rao, Mohammad Amin Behzadi, Roya Feyznezhad, Gregory S. Lambert, Rajnish Kumar, Madhu Kumar, Weiming Yang, Xunqing Jiang, Christina C. Luo, Arthur Nadas, James Arthos, Xiang-Peng Kong, Hui Zhang, Catarina E. Hioe, Catarina E. Hioe, J. Andrew Duty   +16 more
doaj   +1 more source