Results 81 to 90 of about 5,218,351 (211)

Extending the Targets for Coronavirus Antivirals Beyond That of Approved Drugs: Insights From Preclinical Research

Microbial Biotechnology, Volume 19, Issue 5, May 2026.
Chemical structure of RIBOTAC inhibitor with metabolic handle binding as nucleotide analogue to SARS‐CoV‐2 RNA dependent RNA polymerase, its linker and the RNase L recruiter which binds RNase L monomers and mediates their dimerization that actives nuclease activity degrading the viral RNA.
Harald Brüssow
wiley   +1 more source

HIV induces synaptic hyperexcitation via cGMP-dependent protein kinase II activation in the FIV infection model.

PLoS Biology, 2018
Over half of individuals infected with human immunodeficiency virus (HIV) suffer from HIV-associated neurocognitive disorders (HANDs), yet the molecular mechanisms leading to neuronal dysfunction are poorly understood. Feline immunodeficiency virus (FIV)
Keira Sztukowski, Kaila Nip, Paige N Ostwald, Matheus F Sathler, Julianna L Sun, Jiayi Shou, Emily T Jorgensen, Travis E Brown, John H Elder, Craig Miller, Franz Hofmann, Sue VandeWoude, Seonil Kim   +12 more
doaj   +1 more source

X4 Human immunodeficiency virus type 1 gp120 promotes human hepatic stellate cell activation and collagen I expression through interactions with CXCR4.

PLoS ONE, 2012
Background & aimsPatients coinfected with HIV-1 and HCV develop more rapid liver fibrosis than patients monoinfected with HCV. HIV RNA levels correlate with fibrosis progression implicating HIV directly in the fibrotic process.
Feng Hong, Yedidya Saiman, Chuanping Si, Arevik Mosoian, Meena B Bansal   +4 more
doaj   +1 more source

Beyond the Barrier: Epithelial Cells as Immune Sentinels in the Female Genital Tract

American Journal of Reproductive Immunology, Volume 95, Issue 5, May 2026.
ABSTRACT Epithelial cells (ECs) of the female genital tract (FGT) serve as an essential barrier and the first line of defense against sexually transmitted pathogens. Beyond providing a physical barrier, these cells actively contribute to immune responses through pathogen recognition, cytokine release, and modulation of adaptive immune responses ...
Lauren Jirik, Shreya Joshi, Aisha Nazli, Charu Kaushic   +3 more
wiley   +1 more source

Human immunodeficiency virus 1 glycoprotein 120 induces endoplasmic reticulum stress in neurons

Cell Death and Disease
People living with Human Immunodeficiency Virus (HIV) (PLWH) may develop HIV-associated neurocognitive disorder (HAND) despite the use of antiretroviral therapy.
Christy Agbey, Lee A. Campbell, Thieu Phan, Gerard Ahern, Italo Mocchetti   +4 more
doaj   +1 more source

Helix-A peptide prevents gp120-mediated neuronal loss

Molecular Brain, 2019
Aim The human-immunodeficiency virus (HIV) envelope protein gp120 promotes synaptic damage similar to that observed in people living with HIV who have neurocognitive disorders.
Valeria Avdoshina, Francesca Taraballi, Ennio Tasciotti, Aykut Üren, Italo Mocchetti   +4 more
doaj   +1 more source

Behavioral Evidence for a Tau and HIV-gp120 Interaction

, 2022
Despite successful virologic control with combination antiretroviral therapy (cART), about half of people living with the human immunodeficiency virus-1 (HIV) develop an HIV-associated neurocognitive disorder (HAND).
Yin, Linda, Benamar, Khalid, Murali Vijayan, Linda Yin, P. Hemachandra Reddy, Khalid Benamar, Vijayan, Murali, Reddy, P. Hemachandra   +7 more
core   +1 more source

In Silico Identification of Novel Aromatic Compounds as Potential HIV-1 Entry Inhibitors Mimicking Cellular Receptor CD4

Viruses, 2019
Despite recent progress in the development of novel potent HIV-1 entry/fusion inhibitors, there are currently no licensed antiviral drugs based on inhibiting the critical interactions of the HIV-1 envelope gp120 protein with cellular receptor CD4.
Alexander M. Andrianov, Grigory I. Nikolaev, Yuri V. Kornoushenko, Wei Xu, Shibo Jiang, Alexander V. Tuzikov   +5 more
doaj   +1 more source

Search for antiviral functions of potentially protective antibodies against V2 region of HIV-1

Human Vaccines & Immunotherapeutics, 2020
In the only successful RV144 vaccine trial to date, high levels of antibodies (Abs) against the V2 region of the virus envelope protein gp120 correlated with reduced HIV-1 infection.
Miroslaw K. Gorny
doaj   +1 more source

Positive In Vivo Selection of the HIV-1 Envelope Protein gp120 Occurs at Surface-Exposed Regions [PDF]

, 2017
The rapid evolution of human immunodeficiency virus (HIV) envelope represents a major challenge to vaccine and drug development, particularly because the underlying mechanisms are not completely understood.
Joos, Beda, Günthard, Huldrych F., Böni, Jürg, Trkola, Alexandra, Wong, Joseph K., Schweizer, Andreas, Kuster, Herbert, Fischer, Marek, Weber, Rainer   +8 more
core