Results 241 to 250 of about 1,048,882 (334)

Retrospective analysis of CD4 trends at district levels in South Africa between 2013 and 2023. [PDF]

South Afr J HIV Med
Cassim N, da Silva P, Glencross DK, Stevens WS, Coetzee LM.   +4 more
europepmc   +1 more source

Correlation entre le diagnostic tdm et irm des lesions encephaliques et le taux de cd4 chez les pv-vih: a propos de 81 cas colligés au CHU de yopougon

, 2018
SANOGO, Abdoulaye Sidiki
openalex   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

Feasibility and testing outcomes of task-shared implementation of advanced HIV disease point of care tests in Beira (Mozambique) and Kinshasa (DRC). [PDF]

PLoS One
Ndlovu Z, Nhandara R, Govender K, Mpande-Nyasulu F, Kabwe E, Flores A, Mekiedje C, Kyembe L, Bimansha C, Tomas TC, Penna L, da Silva M, Tauro MJ, Bonde AJ, Miguel LR, Manusso PD, Mucinya G, Nzomukunda Y, Ndombe R, Chuy RI, Mboyo A, Ellman T, Fatti G.   +22 more
europepmc   +1 more source

Oral Streptococcus salivarius Couples Neutrophil IRGM1 Signaling to NET Formation and Colorectal Cancer Metastasis

Advanced Science, EarlyView.
The oral bacterium Streptococcus salivarius promotes colorectal cancer metastasis by inducing neutrophil extracellular trap (NET) formation. Mechanistically, IRGM1–IQGAP1 interaction activates Wnt5a–PI3K/AKT signaling in neutrophils, driving NET‐mediated tumor progression.
Fengyi Liu, Yuan Wang, Hengxuan Cai, Qianwen Yue, Xueli Liu, Xuanwen Bao, Zeng Wang, Xuehan Li, Lai Wei, Zhihua Zhang, Fan Xing, Yi Xu, Xianjun Li, Wei Xu   +13 more
wiley   +1 more source

Correction: Protective efficacy of a 'pan-fungal' vaccination strategy against experimental <i>Pneumocystis</i> infection in drug-immunosuppressed macaques. [PDF]

Front Immunol
Rabacal W, Hu A, Kirton G, Chapman TI, Wychrij D, Oworae KO, Norris KA.   +6 more
europepmc   +1 more source

Kinetics of Human Immunodeficiency Virus Type 1 Decay following Entry into Resting CD4 ⁺ T Cells

, 2005
Yan Zhou, Haili Zhang, Janet D. Siliciano, Robert F. Siliciano   +3 more
openalex   +1 more source

USP35 Acts as a Deubiquitinating Enzyme for ID3 to Promote Immune Escape in Colorectal Cancer

Advanced Science, EarlyView.
USP35 stabilizes ID3 expression by deubiquitinating the K2/K30 site, thereby upregulating PD‐L1 and promoting immune escape in colorectal cancer. IU1, an inhibitor of USP35 enzyme activity, has been shown to inhibit USP35, thereby accelerating ID3 degradation, enhancing CD8+ T cell killing, and reversing the immunosuppressive microenvironment ...
Wenxin Chen, Ling Wang, Hongmei Fan, Lisheng Li, Lingyu Zhang, Ruoxin Li, Fang Liu, Fuli Wen, Yunbin Ye, Chuanzhong Huang   +9 more
wiley   +1 more source

CD4⁺ T cells in cancer: dual roles, exhaustion, and therapeutic breakthroughs. [PDF]

Cancer Biol Med
Zhang Y, Xu J, Pan S, Wang Y, Zhao Q, Huang Z, Hu C, Cheng X.   +7 more
europepmc   +1 more source

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source