Results 271 to 280 of about 136,526 (307)
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Critical Reviews in Clinical Laboratory Sciences, 2002
CD44 is a multistructural and multifunctional cell surface molecule involved in cell proliferation, cell differentiation, cell migration, angiogenesis, presentation of cytokines, chemokines, and growth factors to the corresponding receptors, and docking of proteases at the cell membrane, as well as in signaling for cell survival.
David, Naor +4 more
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CD44 is a multistructural and multifunctional cell surface molecule involved in cell proliferation, cell differentiation, cell migration, angiogenesis, presentation of cytokines, chemokines, and growth factors to the corresponding receptors, and docking of proteases at the cell membrane, as well as in signaling for cell survival.
David, Naor +4 more
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European Journal of Cancer, 1995
Alternative splicing of ten different variant exons (v1-v10) is responsible for the creation of a large number of different CD44 surface proteins. Some of these proteins play decisive roles in the metastatic spread of rat tumours. Also in human cancers, CD44 splice variants are frequently expressed in advanced states of tumorigenesis.
Herrlich, P., Pals, S. T., Ponta, H.
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Alternative splicing of ten different variant exons (v1-v10) is responsible for the creation of a large number of different CD44 surface proteins. Some of these proteins play decisive roles in the metastatic spread of rat tumours. Also in human cancers, CD44 splice variants are frequently expressed in advanced states of tumorigenesis.
Herrlich, P., Pals, S. T., Ponta, H.
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Expression of CD44s and CD44 splice variants in human melanoma
Oncology Reports, 2002The ability of tumor cells to adhere and detach from extracellular matrix and endothelial cells, is a crucial step in the metastatic process and may alter the clinical prognosis of some human tumors such as melanomas. CD44, the major cell surface receptor for hyaluronate, has been implicated in cell adhesion and in tumor progression.
Stella Maris, Ranuncolo +10 more
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Frontiers in Bioscience, 1998
In this review we discuss the structural elements of CD44 that have been shown to be involved in specific functions. To this end, we focus primarily on experiments in which CD44 constructs are transfected into cells whose function is then assayed. The hyaluronan binding function of CD44 has been assayed in cell lines and in fusion proteins, termed CD44-
J, Lesley, R, Hyman
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In this review we discuss the structural elements of CD44 that have been shown to be involved in specific functions. To this end, we focus primarily on experiments in which CD44 constructs are transfected into cells whose function is then assayed. The hyaluronan binding function of CD44 has been assayed in cell lines and in fusion proteins, termed CD44-
J, Lesley, R, Hyman
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CD44 in inflammation and metastasis
Glycoconjugate Journal, 1997CD44 is a major cell surface receptor for the glycosaminoglycan, hyaluronan (HA). CD44 binds HA specifically, although certain chondroitin-sulfate containing proteoglycans may also be recognized. CD44 binding of HA is regulated by the cells in which it is expressed. Thus, CD44 expression alone does not correlate with HA binding activity.
J, Lesley +4 more
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CD44 in hematological neoplasias
Annals of Hematology, 2011The CD44 protein family spans a large group of transmembrane glycoproteins acquired by alternative splicing and post-translational modifications. The great heterogeneity in molecular structure is reflected in its various important functions: CD44 mediates (1) interaction between cell and extracellular matrix, (2) signal submission, e.g., by acting as ...
Magdalena Katharina, Hertweck +2 more
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The International Journal of Biochemistry & Cell Biology, 2002
CD44 is a widely expressed cell surface hyaluronan receptor which plays a key role in mediating cell migration. A number of recent papers demonstrating an interplay between CD44 and matrix metalloproteinases (MMPs) have shed important insights into the molecular mechanisms underlying these events.
Clare M, Isacke, Helen, Yarwood
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CD44 is a widely expressed cell surface hyaluronan receptor which plays a key role in mediating cell migration. A number of recent papers demonstrating an interplay between CD44 and matrix metalloproteinases (MMPs) have shed important insights into the molecular mechanisms underlying these events.
Clare M, Isacke, Helen, Yarwood
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Blood, 2006
CD44, a transmembrane adhesion molecule involved in binding and metabolism of hyaluronan, has additional functions in inflammatory and immune responses, contributing to the ingestion and clearance of particles and apoptotic cells. Our goal was to determine the specific role of CD44 in phagocytosis and whether it functions as a primary or accessory ...
Eric, Vachon +10 more
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CD44, a transmembrane adhesion molecule involved in binding and metabolism of hyaluronan, has additional functions in inflammatory and immune responses, contributing to the ingestion and clearance of particles and apoptotic cells. Our goal was to determine the specific role of CD44 in phagocytosis and whether it functions as a primary or accessory ...
Eric, Vachon +10 more
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Expression of CD44 and the pattern of CD44 alternative splicing in uveal melanoma
Melanoma Research, 1996In cutaneous melanoma, the standard CD44 molecule is abundantly expressed, whereas the expression of certain splice variants is related to tumour progression and to the metastatic potential of the cell line. In the present study we have investigated the expression of CD44 and the pattern of CD44 alternative splicing in uveal melanoma in relation to the
Danen, E.H.J. +4 more
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Clinical Orthopaedics & Related Research, 2004
Stability of cell-matrix interactions promotes tissue homeostasis, and matrix receptors provide for the assembly and retention of matrix as well as the linkage to the signal transduction pathways activated in response to changes within the extracellular matrix. Therefore, changes in cell-matrix interactions may influence cell responses to cytokines and
Cheryl B, Knudson, Warren, Knudson
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Stability of cell-matrix interactions promotes tissue homeostasis, and matrix receptors provide for the assembly and retention of matrix as well as the linkage to the signal transduction pathways activated in response to changes within the extracellular matrix. Therefore, changes in cell-matrix interactions may influence cell responses to cytokines and
Cheryl B, Knudson, Warren, Knudson
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