Results 71 to 80 of about 17,628 (245)

CD46 knock-out using CRISPR/Cas9 editing of hTERT immortalized human cells modulates complement activation.

PLoS ONE, 2019
The kidney is especially sensitive to diseases associated with overactivation of the complement system. While most of these diseases affect kidney glomeruli and the microvasculature, there is also evidence for tubulointerstitial deposition of complement ...
Matthias Wieser, Teresa Francisci, Daniel Lackner, Tilmann Buerckstuemmer, Kamilla Wasner, Wolf Eilenberg, Anton Stift, Markus Wahrmann, Georg A Böhmig, Johannes Grillari, Regina Grillari-Voglauer   +10 more
doaj   +1 more source

Organ Transplantation: Current Status, Challenges, and Future Prospects

MedComm, Volume 7, Issue 1, January 2026.
Organ transplantation success relies on precise modulation of the alloimmune response across distinct temporal phases of rejection. Hyperacute rejection results from preformed antibodies activating complement and causing thrombosis, while acute rejection involves T cell‐ and antibody‐mediated mechanisms that drive endothelial activation and ...
Xinqiang Li, Ruidong Ding, Jinzhen Cai
wiley   +1 more source

Native and engineered tropism of vectors derived from a rare species D adenovirus serotype 43 [PDF]

, 2016
Unique molecular properties of species D adenoviruses (Ads)-the most diverse yet underexplored group of Ads-have been used to develop improved gene vectors. The low seroprevalence in humans of adenovirus serotype 43 (Ad43), an otherwise unstudied species
Amalfitano, Arnberg, Baker, Bammler, Barouch, Barry, Barry, Barry, Boulanger, Byrnes, Curiel, Curiel, Curiel, Curiel, Cusack, Drescher, Engler, Finberg, Follen, Francischetti, Gall, Goudsmit, Havenga, Hemmi, Hendriks, Holterman, Krasnykh, Krasnykh, Krasnykh, Krasnykh, Lieber, Lieber, Lieber, Mansfield, Mehtali, Morrison, Nemerow, Nemerow, Nemerow, Nemerow, Pettersson, Richardson, Schmidt, Shayakhmetov, Sprangers, Stahl, Stehle, Stehle, Stehle, van Rooijen, Wadell, Wadell, Wickham, Wickham, Wickham   +54 more
core   +1 more source

Alteration of membrane complement regulators is associated with transporter status in patients on peritoneal dialysis. [PDF]

PLoS ONE, 2017
INTRODUCTION:A growing body of evidence from animal models and cell culture studies indicate an important role of a local regulatory complement system (CS) in peritoneal injury during peritoneal dialysis (PD).
Daniel Kitterer, Dagmar Biegger, Stephan Segerer, Niko Braun, M Dominik Alscher, Joerg Latus   +5 more
doaj   +1 more source

Single‐Cell Multi‐Omics Reveals B2M‐Mediated Myeloid Reprogramming and Constructs a Predictive Model for Early Hepatocellular Carcinoma Recurrence

The FASEB Journal, Volume 39, Issue 24, 31 December 2025.
Single‐cell multi‐omics integration reveals that B2M‐mediated immune reprogramming drives early HCC recurrence by affecting myeloid cell activity. ABSTRACT Early recurrence remains a major challenge in the management of hepatocellular carcinoma (HCC), yet its molecular mechanisms are not fully understood.
Zhenyao Tan, Yezhen Tang, Bendong Chen, Yongxue Lv, Bozhi Zhang, Kejun Liu, Yang Bu   +6 more
wiley   +1 more source

Human CD46 aberrant splicing in transgenic mice

Gene, 1997
RNA analysis of mice transgenic for human CD46 reveals almost undetectable levels of the expected transcript and the accumulation of a 900 nt shorter species. cDNA cloning and sequence analysis of this variant demonstrate an aberrant splicing of the transgene RNA.
L C, Mulder, M, Rossini, M, Mora
openaire   +2 more sources

Analysis of meteorological data from RRS Charles Darwin cruises CD46 and CD47 (BOFS experiment) [PDF]

, 1993
The IOSDL MultiMet meteorological instrumentation system was used during the BOFS experiment on RRS Charles Darwin cruises 46 and 47. This report describes and evaluates the quality of the meteorological data obtained.
Birch, K.G., Pascal, R.W., Taylor, P.K., Tiddy, R.J.   +3 more
core  

Myasthenia gravis thymus: complement vulnerability of epithelial and myoid cells, complement attack on them, and correlations with autoantibody status. [PDF]

, 2007
Am J Pathol. 2007 Sep;171(3):893-905. Epub 2007 Aug 3. Myasthenia gravis thymus: complement vulnerability of epithelial and myoid cells, complement attack on them, and correlations with autoantibody status.
Adams, Alexander Marx, Angela Vincent, Aurea Canelhas, B. Paul Morgan, Beeson, Berrih, Castleman, Cole, Dashiell, Daveau, Davies, Drachman, Engel, Erik Niks, Evoli, Flores, Fosbrink, Francesco Scaravilli, French, Gasque, Graus, Hageman, Hoch, Hsi, Jan J.G.M. Verschuuren, Kaminski, Kaminski, Kyewski, Lampert, Lauriola, Leite, Lin, MacLennan, MacLennan, Margaret Jones, Maria I. Leite, Mason, Matthews, McConville, Meraouna, Monsinjon, Morgan, Morgan, Morgan, Nakano, Navenot, Nick Willcox, Ohta, Philipp Ströbel, Plested, Pratt, Ralf Gold, Roxanis, Roxanis, Rus, Safar, Sanders, Schluep, Schluep, Shiono, Sims, Sonia Berrih-Aknin, Spreadbury, Sprott, Tzartos, van Beek, Vincent, Vincent, Wakkach, Wekerle, Zhang   +71 more
core   +2 more sources

Automaton-based parsing for lexicalized grammars [PDF]

, 1997
In wide-coverage lexicalized grammars many of the elementary structures have substructures in common. This means that during parsing some of the computation associated with different structures is duplicated. This paper explores ways in which the grammar
Evans, Roger, Weir, David
core   +2 more sources

Microparticle-mediated transfer of the viral receptors CAR and CD46, and the CFTR channel in a CHO cell model confers new functions to target cells.

PLoS ONE, 2012
Cell microparticles (MPs) released in the extracellular milieu can embark plasma membrane and intracellular components which are specific of their cellular origin, and transfer them to target cells.
Gaëlle Gonzalez, Cyrielle Vituret, Attilio Di Pietro, Marc Chanson, Pierre Boulanger, Saw-See Hong   +5 more
doaj   +1 more source