Results 71 to 80 of about 18,453 (236)

Canine distemper virus neutralization activity is low in human serum and it is sensitive to an amino acid substitution in the hemagglutinin protein [PDF]

, 2015
© 2015 Elsevier Inc.Serum was analyzed from 146 healthy adult volunteers in eastern Africa to evaluate measles virus (MV) and canine distemper virus (CDV) neutralizing antibody (nAb) prevalence and potency.
Allen, S, Anzala, O, Domi, A, Driscoll, J, Fast, P, Gilmour, J, Kamali, A, Karita, E, Parks, CL, Price, MA, Sanders, EJ, Wallace, OL, Wright, KJ, Zhang, X   +13 more
core   +1 more source

T cells from newly diagnosed multiple sclerosis patients have enhanced responsiveness to CD46 activation

Clinical and Experimental Neuroimmunology, EarlyView.
Abstract Objective To evaluate the responsiveness of T cells from newly diagnosed multiple sclerosis (MS) patients to CD46 co‐stimulation, a membrane co‐factor protein potentially involved in MS pathogenesis. Methods T cells from MS patients and non‐diseased symptomatic controls (SC) were activated in vitro with or without αCD46 antibody co‐stimulation.
Linda Sundvall, Litten S. Rossen, Vivien R. Schack, Bettina Bundgaard, Peter V. Rasmussen, Thor Petersen, Per Höllsberg   +6 more
wiley   +1 more source

Regulators of complement activity mediate inhibitory mechanisms through a common C3b‐binding mode [PDF]

, 2016
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Atkinson, John P, Bertram, Paula, Forneris, Federico, Granneman, Joke CM, Gros, Piet, Hauhart, Richard, Lambris, John D, Lin, Zhuoer, Liszewski, M. Kathryn, Ricklin, Daniel, Sfyroera, Georgia, Tzekou, Apostolia, Volokhina, Elena, Wu, Jin, Xue, Xiaoguang   +14 more
core   +2 more sources

Anti-Neu5Gc and anti-non-Neu5Gc antibodies in healthy humans. [PDF]

PLoS ONE, 2017
Our group previously investigated the levels of anti-Gal and anti-nonGal IgM and IgG in a cohort of 75 healthy humans of various backgrounds, and found some significant differences related to factors such as age, gender, ABO blood group, diet ...
Bingsi Gao, Cassandra Long, Whayoung Lee, Zhongqiang Zhang, Xiaotian Gao, Doug Landsittel, Mohamed Ezzelarab, David Ayares, Yuliang Huang, David K C Cooper, Yi Wang, Hidetaka Hara   +11 more
doaj   +1 more source

PD‐L1 Promotes Immunological Tolerance and Enhances Visual Protection of hESC‐RPE Grafts in Retinal Degeneration

Cell Proliferation, EarlyView.
We generated immune‐tolerant mature hESC‐RPE cells by overexpressing PD‐L1. PD‐L1‐expressing hESC‐RPE grafts exhibited significantly higher survival, reduced apoptosis and enhanced visual protection in retinal degeneration models, which presents an alternative target to improve the efficiency of hESC‐RPE‐based therapy for AMD. ABSTRACT Immune rejection
Bowen Li, Xue Zhang, Yajie Fang, Min Chen, Qiyou Li, Yuxiao Zeng, Chunge Ren, Chengang Wang, Yingxue Lv, Jia Lu, Hongling Liu, Yong Liu   +11 more
wiley   +1 more source

Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism

Nature Communications, 2018
The induction of human CD4+ Th1 cells requires autocrine stimulation of the complement receptor CD46 in direct crosstalk with a CD4+ T cell-intrinsic NLRP3 inflammasome. However, it is unclear whether human cytotoxic CD8+ T cell (CTL) responses also rely
G. Arbore, E. West, J. Rahman, G. Le Friec, Nathalie Niyonzima, M. Pirooznia, I. Tunc, P. Pavlidis, N. Powell, Yuesheng Li, Po-ching Liu, A. Servais, L. Couzi, V. Frémeaux-Bacchi, L. Plaçais, A. Ferraro, Patrick R. Walsh, D. Kavanagh, B. Afzali, P. Lavender, H. Lachmann, C. Kemper   +21 more
semanticscholar   +1 more source

Production and Functional Verification of 8‐Gene (GGTA1, CMAH, β4GalNT2, hCD46, hCD55, hCD59, hTBM, hCD39)‐Edited Donor Pigs for Xenotransplantation

Cell Proliferation, EarlyView.
Schematic representation of generation of 8‐gene‐edited cloned pigs and their verification by pig to non‐human primate kidney xenotransplantation. ABSTRACT Gene‐edited (GE) pig‐to‐human xenotransplantation continues to make breakthroughs, but which kind of gene combination is suitable for organ‐specific transplantation remains unclear.
Jiaoxiang Wang, Kaixiang Xu, Tao Liu, Heng Zhao, Muhammad Ameen Jamal, Gen Chen, Xiaoying Huo, Chang Yang, Deling Jiao, Taiyun Wei, Hanfei Huang, Hongfang Zhao, Jianxiong Guo, Fengchong Wang, Xiong Zhang, Kai Liu, Siming Qu, Gang Wang, Hui Guo, Gang Chen, Hong‐Ye Zhao, Zhong Zeng, Kefeng Dou, Hong‐Jiang Wei   +23 more
wiley   +1 more source

Plac1+ Tumor Cell‐Treg Interplay Supports Tumorigenesis and Progression of Head and Neck Cancer

Advanced Science, Volume 12, Issue 17, May 8, 2025.
Meng et al. screen genes in the CTAs family and find Plac1 is specifically expressed in head and neck squamous cell carcinoma (HNSCC) cells. They reveal that Plac1 expression promotes HNSCC progression directly by activating PI3K/AKT signaling pathway.
Xiaoyan Meng, Zhonglong Liu, Lu Zhao, Ran Li, Luoman Gan, Liren Cao, Jingjing Sun, Lingfang Zhang, Yue He   +8 more
wiley   +1 more source

Complement in Motion: The Evolution of CD46 from a Complement Regulator to an Orchestrator of Normal Cell Physiology

Journal of Immunology, 2019
T he classic pathogen-fighting functions of our microbe sensing systems, such as the TLRs, the Nod-like receptors, and several proteins of the complement system, had been defined relatively rapidly after their discovery (1, 2).
M. Liszewski, C. Kemper
semanticscholar   +1 more source

Complexities in human herpesvirus-6A and -6B binding to host cells [PDF]

, 2006
Human herpesvirus-6A and -6B uses the cellular receptor CD46 for fusion and infection of the host cell. The viral glycoprotein complex gH–gL from HHV-6A binds to the short consensus repeat 2 and 3 in CD46. Although all the major isoforms of CD46 bind the
Höllsberg, Per, Pedersen, Simon Metz
core   +1 more source