Results 181 to 190 of about 29,411 (265)

ITCH‐Mediated Ubiquitination and Degradation of THBS1: A Key Mechanism for Enhancing Mitochondrial Biogenesis and Alleviating Mouse Skeletal Muscle Atrophy

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim Skeletal muscle atrophy is tightly associated with maladaptive alterations in mitochondrial function and morphology. Itchy E3 ubiquitin‐protein ligase (ITCH) modulates mitochondria, and thrombospondin 1 (THBS1) positively regulates muscle atrophy, but their roles in muscle atrophy are unclear. Methods A muscle atrophy model was established
Wan Yu, Yanteng Wang, Na Li, Difei Wang
wiley   +1 more source

Disruption of the CD47-SIRPα Axis Causes Profound Reduction of Parasitaemia in Mice Infected With Babesia microti. [PDF]

Parasite Immunol
Mohammad S, Brasov I, Gottshall S, Robins S, Rashid S, Bradford R, Molestina RE.   +6 more
europepmc   +1 more source

Genomic Evolution and Immune Contexture With Therapeutic Relevance in Pancreatic Neuroendocrine Neoplasms

Cancer Science, Volume 117, Issue 10, Page 2619-2635, October 2026.
Lineage‐dependent immunogenomic landscapes and biologically informed therapy in pancreatic neuroendocrine neoplasms. Pancreatic neuroendocrine neoplasms display lineage‐dependent immunogenomic landscapes, in which genomic alterations, epigenetic states, antigen‐presentation status, immune‐cell infiltration, and suppressive microenvironments co‐evolve ...
Yohei Tabe, Eito Nakagawa, Daisuke Asano, Eriko Katsuta, Daisuke Ban, Shogo Kumagai   +5 more
wiley   +1 more source

Integrative Single‐Cell Transcriptomics, Multi‐Omics Analyses, and Computational Pharmacology Reveal Macrophage Heterogeneity and the Putative THBS1‐CD36 Axis in Coronary Atherosclerosis

Chemical Biology &Drug Design, Volume 108, Issue 4, October 2026.
Single‐cell and multi‐omics analyses identified THBS1+ macrophages as a terminally differentiated, hypoxia‐adaptive population driving coronary atherosclerosis through THBS1‐CD36 signaling with lymphatic endothelial cells. Targeting CD36 with SMS121 and leveraging a THBS1+ macrophage gene signature enabled therapeutic prediction and accurate risk ...
Jianpeng Li, Xinrui Liu, Run Shi, Lin Yang, Rong Gu   +4 more
wiley   +1 more source

Alantolactone inhibits T-cell lymphoma progression by suppressing CD47 expression via the PI3K/AKT and ERK signaling pathways. [PDF]

Apoptosis
Li X, Pang N, Chen Y, Pan T, Sun W, Chen B, Xie F, Mu Y, Li N.   +8 more
europepmc   +1 more source

ASXL1 in proinflammatory macrophages attenuates inflammatory activation and macrophage‐mediated renal tubular epithelial cell damage in acute kidney injury

Physiological Reports, Volume 14, Issue 19, October 2026.
ASXL1 in inflammatory macrophages attenuates renal tubular cell damage through coordinated histone modification of H3K27me3 and H3K4me3 in acute kidney injury. Abstract Macrophages are major contributors to inflammatory responses in acute kidney injury (AKI) and rapidly alter their gene expression through epigenetic regulation.
Yoshiyasu Ogura, Takehito Sugasawa, Masaomi Nangaku, Imari Mimura   +3 more
wiley   +1 more source

UBA1 enhances phagocytosis by suppressing CD47 expression in small cell lung cancer. [PDF]

Front Oncol
Li D, Li N, Liu Y, Chen J, Wang Z, Chen L, Wu H, Lan H.   +7 more
europepmc   +1 more source

Dynamic Remodeling of Oocyte‐Granulosa Cell Communication During Bovine Folliculogenesis Revealed by Transcriptomic Meta‐Analyses

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Bidirectional communication between oocytes and granulosa cells undergoes progressive remodeling during bovine folliculogenesis. Integrative transcriptomic analysis identified stage‐specific ligand‐receptor signaling networks coordinating structural, metabolic, and developmental processes.
Noemi Monferini, Ludovica Donadini, Pritha Dey, Federica Franciosi, Valentina Lodde, Maria Belen Rabaglino, Alberto Maria Luciano   +6 more
wiley   +1 more source

Therapeutic biologics interference in serological and pre-transfusion testing. [PDF]

Front Immunol
Trummer P, Habicht CP, Scharberg EA, Schneeweiß C.   +3 more
europepmc   +1 more source

Tackling anti-tumor macrophage function through genome engineering. [PDF]

Mol Ther Oncol
Kaushal R, Skeate JG, Crane AT.
europepmc   +1 more source