GV1001 Reprograms CD47 Immune Checkpoint to Restore Macrophage Antitumor Activity in Oral Squamous Cell Carcinoma. [PDF]
Chen W +5 more
europepmc +1 more source
RNA Modifications: Current Understandings and Future Perspectives
Types of RNA modification. We have summarized the currently common types of RNA modifications, including ac4C, m6A, m1A, m5C, m3C, m7G, and ψ, and visually characterized their features through structural formulas. The characteristic structures are marked with a background color different from the background color.
Shiyu Xiao +7 more
wiley +1 more source
CD47 as a prognostic biomarker and potential immunotherapy target in penile squamous cell carcinoma. [PDF]
Zhang J +11 more
europepmc +1 more source
Expression of mouse CD47 on human cancer cells profoundly increases tumor metastasis in murine models [PDF]
core +1 more source
Targeting Tumor Stroma: Current Challenges and Future Directions
Figure 1. Mechanism of ECM reprogramming. Cancer‐associated fibroblasts (CAFs), cancer‐associated macrophages (CAMs), and other mesenchymal cells alter the ECM composition and increase its stiffness by depositing matrix components such as collagen and hyaluronic acid, and secreting cross‐linking agents like lysyl oxidase homolog 2 (LOXL2).
Siwei Wang +7 more
wiley +1 more source
Establishment of Predictive Models for Second Hepatoma Recurrence. [PDF]
Su M, Zhong W, Chen Z, Zhang G.
europepmc +1 more source
Efferocytosis: Signaling Pathways and New Therapeutic Strategies for Diseases
1. Efferocytosis coordinates molecular signaling and metabolic reprogramming to resolve inflammation. 2. Efferocytosis dysfunction underlies four conserved pathological hallmarks across diseases. 3. Therapeutic strategies targeting efferocytosis should be context‐dependent: enhance or inhibit based on disease type. ABSTRACT Efferocytosis—the phagocytic
Lei Wang +6 more
wiley +1 more source
Photodynamic therapy with zinc phthalocyanine suppresses immune checkpoints in human melanoma cells. [PDF]
Doustvandi MA +6 more
europepmc +1 more source
A Biomimetic Micro‐Nano System Maximizing ‘Active Transport and Retention’ Effect in Solid Tumors
The Active Transport and Retention (ATR) strategy is realized using a biomimetic micro‐nano system (PG@BAM‐LRC), achieving superior tumor accumulation and efficacy in low‐EPR pancreatic tumors. Platelet (PG)‐derived microcarriers enable tumor‐homing and MMP‐9‐responsive release of nanoliposomes (LRC), while berbamine (BAM) promotes transendothelial ...
Kaiyun Yang +4 more
wiley +1 more source
PAARH suppresses Kupffer cell phagocytosis to promote tumor liver metastasis by upregulating CD47. [PDF]
Li W +10 more
europepmc +1 more source

