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American Journal of Clinical Pathology
Abstract Objectives Recent studies show that blocking CD47-SIRPα interactions is a promising target in checkpoint inhibition for cancer immunotherapy. However, to date, the expression of CD47 is not well characterized in various hematolymphoid neoplasms.
Jingjing Zhang +6 more
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Abstract Objectives Recent studies show that blocking CD47-SIRPα interactions is a promising target in checkpoint inhibition for cancer immunotherapy. However, to date, the expression of CD47 is not well characterized in various hematolymphoid neoplasms.
Jingjing Zhang +6 more
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Brustkrebs: MET+, CD47+ – Prognose düster
Im Focus Onkologie, 2014Sind in Mammakarzinomen des Luminaltyps die Marker MET und CD47 nachweisbar, spricht das fur eine schlechte Prognose: Die Patientinnen leben im Schnitt rund zehn Jahre kurzer als Frauen, deren Tumoren fur MET und CD47 negativ sind.
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Blood, 2005
Comment on Piccio et al, page [2421][1] In the present issue of Blood , Piccio and colleagues report that a member of the signal-regulatory protein (SIRP) family, SIRPβ2, is expressed by T cells, binds to CD47, and costimulates T-cell proliferation.
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Comment on Piccio et al, page [2421][1] In the present issue of Blood , Piccio and colleagues report that a member of the signal-regulatory protein (SIRP) family, SIRPβ2, is expressed by T cells, binds to CD47, and costimulates T-cell proliferation.
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[CD47 and leukemia stem cells].
Zhongguo shi yan xue ye xue za zhi, 2011CD47, also known as integrin-associated protein (IAP), is an immunoglobulin-like protein. It can inhibit the phagocytosis of macrophages through binding with signal-regulatory protein alpha chain of inhibitory receptor on macrophage (SIRPα). The expression of CD47 on normal hematopoietic stem cells (HSCs) is useful for maintaining the stability of HSCs
Qian-Song, Cheng, Xing-Bing, Wang
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Mechanismy regulace povrchové exprese CD47
2017CD47 glycoprotein can be found on the surface of all healthy cells in our body. The interaction of CD47 with inhibitory receptor SIRPα on the macrophage leads to the inhibition of phagocytosis. This makes CD47 irreplaceable for the safe recognition of own cells and removal of aged or apoptotic cells.
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