Results 1 to 10 of about 8,084 (99)

Myokine SIRPα exacerbates kidney disease in diabetes [PDF]

JCI Insight
Mechanisms responsible for skeletal muscle kidney crosstalk have not been defined. We have determined that a circulating mediator, signal regulatory protein α (SIRPα), impairs intracellular insulin-mediated functions.
Jiao Wu, Elisa Russo, Daniela Verzola, Qingtian Li, Helena Zhang, Bhuvaneswari Krishnan, David Sheikh-Hamad, Zhaoyong Hu, William E. Mitch, Sandhya S. Thomas   +9 more
doaj   +2 more sources

SIRPα maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosis

EBioMedicine, 2022
Summary: Background: To determine whether SIRPα can be a diagnostic marker of pulmonary tuberculosis (PTB) and the molecular mechanism of SIRPα regulating macrophages to kill Mycobacterium tuberculosis (MTB).
Di Wang, Yunkai Lin, Feihong Xu, Hui Zhang, Xiaoyan Zhu, Zhen Liu, Yuan Hu, Guanjun Dong, Bingqi Sun, Yanhong Yu, Guoren Ma, Zhigang Tang, Diana Legarda, Adrian Ting, Yuan Liu, Jia Hou, Liwei Dong, Huabao Xiong   +17 more
doaj   +1 more source

Leishmania Infection-Induced Proteolytic Processing of SIRPα in Macrophages

Pathogens, 2023
The shedding of cell surface receptors may bring synergistic outcomes through the loss of receptor-mediated cell signaling and competitive binding of the shed soluble receptor to its ligand.
Hana Hirai, Jing Hong, Wataru Fujii, Chizu Sanjoba, Yasuyuki Goto   +4 more
doaj   +1 more source

Regulation of Phagocyte Migration by Signal Regulatory Protein-Alpha Signaling. [PDF]

PLoS ONE, 2015
Signaling through the inhibitory receptor signal regulatory protein-alpha (SIRPα) controls effector functions in phagocytes. However, there are also indications that interactions between SIRPα and its ligand CD47 are involved in phagocyte ...
Julian Alvarez-Zarate, Hanke L Matlung, Takashi Matozaki, Taco W Kuijpers, Isabelle Maridonneau-Parini, Timo K van den Berg   +5 more
doaj   +1 more source

'Clustering' SIRPα into the plasma membrane lipid microdomains is required for activated monocytes and macrophages to mediate effective cell surface interactions with CD47. [PDF]

PLoS ONE, 2013
SIRPα, an ITIMs-containing signaling receptor, negatively regulates leukocyte responses through extracellular interactions with CD47. However, the dynamics of SIRPα-CD47 interactions on the cell surface and the governing mechanisms remain unclear.
Binh Ha, Zhiyuan Lv, Zhen Bian, Xiugen Zhang, Aarti Mishra, Yuan Liu   +5 more
doaj   +1 more source

Anomalous Levels of CD47/Signal Regulatory Protein Alpha in the Hippocampus Lead to Excess Microglial Engulfment in Mouse Model of Perioperative Neurocognitive Disorders

Frontiers in Neuroscience, 2022
BackgroundPerioperative neurocognitive disorders (PNDs) are common complications of surgical patients, which can lead to prolonged hospitalization, increased complications, and decreased independence and quality of life. However, the underlying molecular
Min Shui, Yi Sun, Dandan Lin, Ziyi Xue, Jianhui Liu, Anshi Wu, Changwei Wei   +6 more
doaj   +1 more source

Modified exosomal SIRPα variants alleviate white matter injury after intracerebral hemorrhage via microglia/macrophages

Biomaterials Research, 2022
Background Despite limited efficiency, modulation of microglia/macrophages has shown to attenuate neuroinflammation after intracerebral hemorrhage (ICH).
Xinjie Gao, Heng Yang, Weiping Xiao, Jiabin Su, Yuwen Zhang, He Wang, Wei Ni, Yuxiang Gu   +7 more
doaj   +1 more source

Tumor-associated macrophages and macrophage-related immune checkpoint expression in sarcomas

OncoImmunology, 2020
Early trials for immune checkpoint inhibitors in sarcomas have delivered mixed results, and efforts to improve outcomes now look to combinatorial strategies with novel immunotherapeutics, including some that target macrophages.
Amanda R. Dancsok, Dongxia Gao, Anna F. Lee, Sonja Eriksson Steigen, Jean-Yves Blay, David M. Thomas, Robert G. Maki, Torsten O. Nielsen, Elizabeth G. Demicco   +8 more
doaj   +1 more source

Structural analysis and binding sites of inhibitors targeting the CD47/SIRPα interaction in anticancer therapy

Computational and Structural Biotechnology Journal, 2021
Cluster of differentiation 47 (CD47)/signal regulatory protein alpha (SIRPα) is a negative innate immune checkpoint signaling pathway that restrains immunosurveillance and immune clearance, and thus has aroused wide interest in cancer immunotherapy ...
Bo Huang, Zhaoshi Bai, Xinyue Ye, Chenyu Zhou, Xiaolin Xie, Yuejiao Zhong, Kejiang Lin, Lingman Ma   +7 more
doaj   +1 more source

SIRPα blockade improves the antitumor immunity of radiotherapy in colorectal cancer

Cell Death Discovery, 2023
High-dose hypofractionated radiotherapy (HRT) is an important anticancer treatment modality that activates antitumor host immune responses. However, HRT for oligometastases of colorectal cancer (CRC) has shown frustrating results in the clinic.
Kai Ji, Yuhan Zhang, Shengpeng Jiang, Lin Sun, Baozhong Zhang, Dongzhi Hu, Jun Wang, Lujun Zhao, Ping Wang, Zhen Tao   +9 more
doaj   +1 more source