Results 161 to 170 of about 665,801 (300)

Tumor vessel sabotage: CD4⁺ T cells enlist macrophages. [PDF]

Signal Transduct Target Ther
Ugel S, De Sanctis F.
europepmc   +1 more source

Functional maturation of CD4⁺CD25⁺CTLA4 ⁺CD45RA⁺ T regulatory cells in human neonatal T cell responses to environmental antigens/allergens

, 2004
Functional maturation of CD4+CD25+CTLA4 +CD45RA+ T regulatory cells in human neonatal T cell responses to environmental antigens ...
PG Holt (14457411), ME Wikström (14458890), BJ Holt (14457651), JW Upham (14458044), GP White (14459550), PD Sly (14453628), CA Thornton (14459547), MJ Sharp (14458614)   +7 more
core  

A Tumor‐Boundary Niche Enriched for PD‐1+CD8+T Cells and BTLA+B Cells Drives Resistance to Immunotherapy in NSCLC

Advanced Science, EarlyView.
A spatial niche composed of BTLA+B cells and CD8+T cells is enriched at the tumor boundary in non‐small cell lung cancer. Within this specialized niche, BTLA+B cells act as a dominant source of IL‐6, upregulating PD‐1 on CD8+T cells via STAT3 signaling.
Jiajuan Wu, Shiying Guo, Leilei Lv, Guiqin Fan, Yu Shen, Qiuxia Qu, Cheng Chen   +6 more
wiley   +1 more source

Discovery of CD4+ T cell-recognized B. pertussis antigens that reduce airway colonization. [PDF]

JCI Insight
Shamseldin MM, Hall JM, Lawrence GM, Hernandez GM, Liu Y, Aubrey AR, Verzani EK, Deora R, Lovett-Racke A, Abelin JG, Dubey P.   +10 more
europepmc   +1 more source

Identification of T CD4+ epitopes of tumoral antigens

, 2007
L'induction d'une immunité efficace contre les tumeurs nécessite de recruter des lymphocytes T CD4+ auxiliaires et spécifiques. De ce fait, les peptides de tumeurs présentés par les molécules HLA II sont de potentiels candidats pour l'immunothérapie anticancéreuse. Le but de ce travail a été l'identification de nouveaux épitopes T CD4+ dérivés de trois
openaire   +1 more source

Sonogenetics Nanomedicine Activates the cGAS‐STING Pathway for Immunotherapy of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
A HER3‐targeted sonogenetic lipid nanoparticle platform is developed for triple‐negative breast cancer therapy. An AI‐designed miniprotein inhibits HER3 signaling, while TRPV4 and NFAT‐responsive IL‐15 plasmids enable ultrasound‐controlled calcium signaling and cytokine expression. The system induces Ca2+ overload, ROS generation, mitochondrial damage,
Junya Song, Yan Liu, Shifeng Zhao, Cheng Zhu, Hongchang Guo, Jin Chang, Jun Kang   +6 more
wiley   +1 more source

M. smegmatis IKEPLUS Immunization Reveals the Mycobacterial Ribosome as a Source of Novel CD4+ T cell Antigens

, 2018
No vaccine candidate has had major success in reducing the enormous global burden of disease due to Mycobacterium tuberculosis (Mtb). Critical to the control of Mtb is the ability of a vaccine to induce a strong CD4+ Tcell response.
Kennedy, Steven C.
core  

Granzyme B PET Imaging Reveals Lgmn+ Macrophage‐Mediated Immune Evasion and Guides Immunotherapy in EGFR‐TKI‐Resistant NSCLC

Advanced Science, EarlyView.
Graphical illustration of 68Ga‐GZB PET/CT imaging reveals immune dynamics post‐EGFR‐TKI resistance in NSCLC; Lgmn+ macrophages‐derived Lgmn‐containing extracellular vesicles inhibit glycolysis, induce CD8+ T cell exhaustion, and targeting Lgmn restores immunotherapy sensitivity.
Dongliang Wang, Wenqin Luo, Qiufang Liu, Wenxuan Tang, Bin Zhu, Jiwei Chen, Qian Zhou, Shuang Tang, Xiaoping Xu, Shaoli Song   +9 more
wiley   +1 more source

Alpha-galactosylceramide as mRNA vaccine adjuvant modulates cellular immunity against tuberculosis and contributes to antigen-specific lung-associated T cells with a TRM-associated phenotype following prime-pull strategy. [PDF]

Front Immunol
Aernout I, Ehouarne T, Mwangi K, Ferrell KC, De Velder M, Swinnen J, Verplancke A, Van Moortel L, De Meyer M, Willems P, Franceschini L, Breckpot K, De Smedt SC, Impens F, Demangel C, Verbeke R, Lentacker I.   +16 more
europepmc   +1 more source

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source