Results 171 to 180 of about 221,142 (316)

Investigating the potential of the Metastasis Associated Antigen 1 (MTA1) for cancer immunotherapy in a murine model

, 2007
Immunotherapeutic approaches to target antigens associated with metastasis could provide a valuable means of targeting metastatic cells specifically. Metastasis Associated Antigen (MTA1) is one such relatively novel antigen, which has been associated ...
Assudani, D
core  

PANX2 Suppresses Lung Adenocarcinoma Progression by Inducing Disulfidptosis and Enhancing Antitumor Immunity

Advanced Science, EarlyView.
ABSTRACT Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality with limited therapeutic options. Disulfidptosis, a novel cell death modality driven by disulfide stress, represents a promising target, yet its regulation in LUAD is poorly defined. Here, we identify Pannexin 2 (PANX2) as a tumor suppressor in LUAD.
Yi Chen, Zhao‐Yu Liu, Gao‐Wen Qu, Run‐Hao Zeng, Wen‐Xia Yao, Yong‐Bing Zhou, Xue Liang, Yu‐Xiong Lai   +7 more
wiley   +1 more source

BCMA‐Engineered Dendritic Cell‐Derived Exosomes as Bi‐Functional Therapeutics Orchestrating Cytokine Sequestration and Immune Activation for Multiple Myeloma

Advanced Science, EarlyView.
A dual‐function cell‐free therapeutic based on DC2.4 cell‐derived exosomes engineered to display BCMA. (Left) Soluble Ligand Sequestration (Decoy Function): DB Exo act as molecular decoys that predominantly sequester soluble APRIL with partial BAFF attenuation, effectively disrupting the NF‐κB survival signaling axis and suppressing myeloma cell ...
Yuqing Zeng, Chao He, Zhibin He, Hongbo Chen, Fang Cheng, Yongjiang Zheng   +5 more
wiley   +1 more source

Whole-protein screening and multi-modal profiling of antigen-specific CD4⁺ T cells at single-cell resolution. [PDF]

Nat Commun
Zhang R, Qi J, McKasson M, Choi J, Gutierrez V, Brennan C, Hong S, Chour W, Ng RH, Xie J, Yuan D, Webster A, Sidhu SK, Anderson A, Chen D, Edmark R, Murray KM, Li S, McDonald C, Rowen L, Wang S, Rasheed Y, Su Y, Wagner JR, Chen JM, Nawaly K, Fu J, Duven A, Forman SJ, Song M, Priceman SJ, Brown CE, Ribas A, Wong DJ, Paulson KG, Drescher CW, Puig-Saus C, Goldman JD, Trimble CL, Heath JR.   +39 more
europepmc   +1 more source

Identification of T CD4+ epitopes of tumoral antigens

, 2007
L'induction d'une immunité efficace contre les tumeurs nécessite de recruter des lymphocytes T CD4+ auxiliaires et spécifiques. De ce fait, les peptides de tumeurs présentés par les molécules HLA II sont de potentiels candidats pour l'immunothérapie anticancéreuse. Le but de ce travail a été l'identification de nouveaux épitopes T CD4+ dérivés de trois
openaire   +1 more source

The function and origin of the CD4+ T cell in the classical Hodgkin lymphoma microenvironment

, 2012
PhDClassical Hodgkin lymphoma (CHL) is a germinal centre B cell malignancy where the bulk of the tumour comprises a non-clonal immune infiltrate enriched for CD4+ T cells.
Greaves, Paul
core  

Tumor‐Infiltrating mregDCs Restrain Anti‐Tumor Immunity in Early Relapse HCC

Advanced Science, EarlyView.
Tumor‐infiltrating mregDCs are regulated by the TNFR2‐non‐canonical NF‐κB axis, which is mediated by TNF‐α secreted by CD161+CD8+ T cells. These mregDCs recruit CD161+CD8+ T cells via the CCL20‐CCR6 axis, forming a positive feedback loop that enhances immunosuppression, promotes early recurrence of HCC, and further confirms TNFR2 as a key therapeutic ...
Zefan Zhang, Lin Ding, Yu Zhong, Haokang Feng, Linglong Huang, Waidong Huang, Chunqing Wang, Arne Östman, Beili Wang, Jian Zhou, Jia Fan, Wei Guo, Liang Wu, Yunfan Sun   +13 more
wiley   +1 more source

How Epstein-Barr Virus Drives Multiple Sclerosis: New Mechanisms and Therapeutic Lessons. [PDF]

MedComm (2020)
Liu D, Fan W, Jiao P.
europepmc   +1 more source

Supramolecular Assembly of Stepped‐Persistent ROS Nanogenerator for Sustained Tumor Immunotherapy

Advanced Science, EarlyView.
ROS catalytic systems often fail to achieve both effective tumor elimination and persistent immune activation due to their monotonous ROS production profiles. A stepped‐persistent ROS nanogenerator was developed by supramolecularly assembling multiple ROS generation modules within a nanofiber structure to simultaneously extend ROS generation duration ...
Zhenqiang Wang, Ming Qin, Wenjing Lai, Shiwen Chen, Fengling Wang, Dandan Xie, Maohua Chen, Changpeng Hu, Kui Wang, Rong Zhang, Guobing Li   +10 more
wiley   +1 more source

Correction: The role of B cells in the pathogenesis of type 1 diabetes. [PDF]

Front Immunol
Wang YN, Li R, Huang Y, Chen H, Nie H, Liu L, Zou X, Zhong J, Zheng B, Gong Q.   +9 more
europepmc   +1 more source