Results 141 to 150 of about 9,613 (181)

Recombinant transmembrane CD59 (CD59‐TM) confers complement resistance to GPI‐anchored protein defective melanoma cells*

Journal of Cellular Physiology, 2002
AbstractProtectin (CD59) is a glycosylphosphatidylinositol (GPI)‐anchored cell membrane glycoprotein, broadly expressed on melanocytic cells, that represents the main restriction factor of complement (C)‐mediated lysis of human melanoma cells. Levels of CD59 expression may impair the clinical efficacy of C‐activating monoclonal antibodies (mAb); thus ...
De Nardo C, Fonsatti E, Sigalotti L, Calabro' L, Colizzi F, Cortini E, Coral S, Altomonte M, Maio M   +8 more
openaire   +3 more sources

Detection of CD59 Using Flow Cytometry

2013
CD59 is the single regulator of the terminal complement pathway. It has been implicated in disease such as Paroxysmal nocturnal hemoglobinuria (PMH) and cancer. Expression of CD59 protects normal and malignant cells from the cytotoxic potential of the complement system.
openaire   +2 more sources

Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets

Proceedings of the National Academy of Sciences of the United States of America, 2022
Benjamin KING, Omar Hmeadi, Anna Blom
exaly  

Soluble CD59 in pregnancy and infancy

Immunology Letters, 1993
L, Bjørge, T S, Jensen, C A, Vedeler, E, Ulvestad, E K, Kristoffersen, R, Matre   +5 more
openaire   +2 more sources

CD59

1998
Alexandra Davies, Peter Lachmann
openaire   +1 more source

CD59

1997
A. Neil Barclay, Marion H. Brown, S.K. Alex Law, Andrew J. McKnight, Michael G. Tomlinson, P. Anton van der Merwe   +5 more
openaire   +1 more source

CD59

2006
openaire   +1 more source

CD59

2011
openaire   +1 more source

Complement Regulator CD59 Protects Against Atherosclerosis by Restricting the Formation of Complement Membrane Attack Complex

Circulation Research, 2009
Xuebin Qin, Weiguo Hu, JOSÉ Halperin
exaly  

CD59

2000
openaire   +1 more source