Results 91 to 100 of about 883,722 (384)

Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors

Nature Communications, 2018
Identifying tumor antigen-specific T cells from cancer patients has important implications for immunotherapy diagnostics and therapeutics. Here, we show that CD103+CD39+ tumor-infiltrating CD8 T cells (CD8 TIL) are enriched for tumor-reactive cells both ...
T. Duhen, Rebekka Duhen, Ryan Montler, Jake Moses, T. Moudgil, N. D. de Miranda, C. Goodall, T. Blair, B. Fox, J. Mcdermott, Shu-ching Chang, G. Grunkemeier, R. Leidner, R. Bell, A. Weinberg   +14 more
semanticscholar   +1 more source

Suboptimal SARS-CoV-2−specific CD8+ T cell response associated with the prominent HLA-A*02:01 phenotype

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance As the recall of CD8+ T cell memory promotes rapid recovery in, for example, influenza, we investigated circulating SARS-CoV-2−specific CD8+ T cells from COVID-19 patients.
Jennifer R. Habel, Thi H. O. Nguyen, C. E. van de Sandt, J. Juno, P. Chaurasia, Kathleen M. Wragg, M. Koutsakos, Luca Hensen, Xiaoxiao Jia, B. Chua, Wuji Zhang, Hyon-Xhi Tan, K. Flanagan, D. Doolan, J. Torresi, Weisan Chen, L. Wakim, Allen C. Cheng, P. Doherty, J. Petersen, J. Rossjohn, A. Wheatley, S. Kent, L. Rowntree, K. Kedzierska   +24 more
semanticscholar   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Effect Of Mangosteen (Garcinia Mangostana) Peel Extract Towards CD8 + T Lymphocytes And CD8 + CD38 Expression In HIV Patients With Antiretroviral Therapy [PDF]

, 2015
Background : HIV/AIDS still being an emerging disease and the AIDS epidemic in Indonesia is one of the fastest growing in Asia. Humans infected with HIV have been shown to be under chronic oxidative stress.
Komala, Ika
core  

Immunological Changes after Cancer Treatment and Participation in an Exercise Program [PDF]

, 2003
Purpose: The purpose of this investigation was to evaluate the impact of undertaking peripheral blood stem cell transplantation (PBST) on T-cell number and function, and to determine the role of a mixed type, moderate intensity exercise program in ...
Andrykowski, Birk, Brenner, Brittenden, Chess, Cohen, Dimeo, Hannet, Henon, Keast, Laperriere, Laperriere, Molrine, Mosmann, Nieman, Nordon, Peters, Pyne, Rigsby, Shephard, Shevde, Spitzer, Talmadge, Uh, Weidemann, Winningham, Woods, Young-Moo   +27 more
core   +2 more sources

CD8⁺T Cells: GITR Matters

The Scientific World Journal, 2012
As many members of the tumor necrosis factor receptor superfamily, glucocorticoid-induced TNFR-related gene (GITR) plays multiple roles mostly in the cells of immune system. CD8+T cells are key players in the immunity against viruses and tumors, and GITR has been demonstrated to be an essential molecule for these cells to mount an immune response.
RONCHETTI, Simona, NOCENTINI, Giuseppe, PETRILLO, MARIA GRAZIA, RICCARDI, Carlo   +3 more
openaire   +5 more sources

Skewed distribution of IL-7 receptor-α-expressing effector memory CD8+ T cells with distinct functional characteristics in oral squamous cell carcinoma.

PLoS ONE, 2014
CD8(+) T cells play important roles in anti-tumor immunity but distribution profile or functional characteristics of effector memory subsets during tumor progression are unclear.
Jang-Jaer Lee, Chiou-Yueh Yeh, Chiau-Jing Jung, Ching-Wen Chen, Mao-Kuang Du, Hui-Ming Yu, Chia-Ju Yang, Hui-Yi Lin, Andy Sun, Jenq-Yuh Ko, Shih Jung Cheng, Yen-Liang Chang, Jean-San Chia   +12 more
doaj   +1 more source

Quantitative multiplex immunofluorescence analysis identifies infiltrating PD1+CD8+ and CD8+ T cells as predictive of response to neoadjuvant chemotherapy in breast cancer

Thoracic Cancer, 2020
Background This study aimed to explore the potentially predictive role and dynamic changes of immune checkpoints on T cell subsets in patients with breast cancer receiving neoadjuvant chemotherapies.
Hongling Liang, Hongsheng Li, Zhi Xie, Tianen Jin, Yu Chen, Zhiyi Lv, Xiaojun Tan, Jia Li, Guodong Han, Weixing He, Ni Qiu, Ming Jiang, Jie Zhou, Haoming Xia, Yongtao Zhan, Lulu Cui, Weiling Guo, Jianqing Huang, Xuchao Zhang, Yi‐long Wu   +19 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Short-term antigen presentation and single clonal burst limit the magnitude of the CD8(+) T cell responses to malaria liver stages.

, 2002
Malaria sporozoites induce swift activation of antigen-specific CD8(+) T cells that inhibit the intracellular development of liver-stage parasites. The length of time of functional in vivo antigen presentation, estimated by monitoring the activation of ...
A. Morrot, Ahmed, Altman, Bruno, Bru  a-Romero, Busch, Carvalho, Carvalho, Clyde, F. Zavala, G.-i. Sano, Gilbert, Goossens, Gray, Herrington, Hou, J. C. R. Hafalla, Kaech, Kundig, L. H. Carvalho, Lalvani, Lau, Li, Mercado, Mullbacher, Murali-Krishna, Oehen, Oliveira-Ferreira, Plebanski, Plebanski, Renggli, Rodrigues, Rodrigues, Rodrigues, Rodrigues, Romero, Scheller, Schneider, Sedegah, Shinkai, Tanchot, van Stipdonk, Vanderberg, Veiga-Fernandes, Weiss   +44 more
core   +2 more sources