Results 91 to 100 of about 394,438 (273)

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source

Cytomegalovirus Colitis in Primary Hypogammaglobulinemia With Normal CD4+ T Cells: Deficiency of CMV-Specific CD8+ T Cells

Frontiers in Immunology, 2019
CMV colitis has been reported in immunocompromized patients with severe deficiency of CD4+ T cells and T cell functions. In this study we present an extensive immunological analysis in a patient with primary hypogammaglobulinemia and CMV colitis who had ...
Sudhanshu Agrawal, Amrita Khokhar, Sudhir Gupta   +2 more
doaj   +1 more source

Positive selection determines T cell receptor V beta 14 gene usage by CD8+ T cells. [PDF]

, 1989
Nan‐Shih Liao, Jonathan S. Maltzman, David H. Raulet   +2 more
openalex   +1 more source

Designing of CD8+ and CD8+-overlapped CD4+ epitope vaccine by targeting late and early proteins of human papillomavirus

Biologics: Targets & Therapy, 2018
Satyavani Kaliamurthi,1 Gurudeeban Selvaraj,1 Aman Chandra Kaushik,2 Ke-Ren Gu,1,3 Dong-Qing Wei1,2 1Centre of Interdisciplinary Science – Computational Life Sciences, College of Food Science and Engineering, Henan University of Technology ...
Kaliamurthi S, Selvaraj G, Kaushik AC, Gu KR, Wei DQ   +4 more
doaj  

The Roles of CD8⁺ and CD4⁺ Cells in Tumor Rejection [PDF]

, 1989
Heiichiro Udono, Masahiro Mieno, Hiroshi Shiku, Eiichi Nakayama   +3 more
openalex   +1 more source

Epigenome‐wide association study, meta‐analysis, and multiscore profiling of whole blood in Parkinson's disease

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objectives An increasing body of evidence indicates altered DNA methylation in Parkinson's disease, yet the reproducibility and utility of such methylation changes are largely unexplored. We aimed to further elucidate the role of dysregulated DNA methylation in Parkinson's disease and to evaluate the biomarker potential of methylation‐based ...
Ingeborg Haugesag Lie, Manuela M. X. Tan, Maren Stolp Andersen, Mathias Toft, Lasse Pihlstrøm   +4 more
wiley   +1 more source

Prognostic significance of CD8 and TCF1 double positive T cell subset in microsatellite unstable gastric cancer

Scientific Reports
Microsatellite instability-high (MSI-H) gastric cancer (GC) exhibits high tumor-infiltrating lymphocyte (TIL) density. Despite the recognized significance of the immune microenvironment in MSI-H GC, our understanding of TIL remains limited.
Juhyeong Park, Soo Kyung Nam, Yoonjin Kwak, Hyeon Jeong Oh, Seong-Ho Kong, Do Joong Park, Hyuk-Joon Lee, Han-Kwang Yang, Hye Seung Lee   +8 more
doaj   +1 more source

The T-cell receptor gamma chain-CD3 complex: implication in the cytotoxic activity of a CD3+ CD4- CD8- human natural killer clone. [PDF]

, 1987
Balbino Alarcón, JE de Vries, Carolyn L. Pettey, Arthur W. Boylston, Hans Yssel, Cox Terhorst, Hergen Spits   +6 more
openalex   +1 more source

CSF cytokine, chemokine and injury biomarker profile of glial fibrillary acidic protein (GFAP) autoimmunity

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Defining the CSF cytokine/chemokine and injury biomarker signature of glial fibrillary acidic protein (GFAP) autoimmunity can inform immunopathogenesis. CSF GFAP‐IgG‐positive samples (N = 98) were tested for 17 cytokines/chemokines, neurofilament light chain (NfL), and GFAP (ELLA, Bio‐Techne).
Yahel Segal, Georgios Mangioris, Vanda Lennon, Binxia Yang, Divyanshu Dubey, Eoin P. Flanagan, Andrew McKeon, John R. Mills, Michel Toledano, Ivana Vodopivec, Sean J. Pittock, Anastasia Zekeridou   +11 more
wiley   +1 more source

Imbalances within the peripheral blood T-helper (CD4+) and T-suppressor (CD8+) cell populations in the reconstitution phase after human bone marrow transplantation [PDF]

, 1988
Andrea Velardi, Adelmo Terenzi, S Cucciaioni, R Millo, CE Grossi, F Grignani, MF Martelli   +6 more
openalex   +1 more source