Results 101 to 110 of about 729,582 (283)

Agonist Anti-GITR Antibody Enhances Vaccine-Induced CD8+ T-Cell Responses and Tumor Immunity [PDF]

, 2006
Adam D. Cohen, Adi Diab, Miguel‐Angel Perales, Jedd D. Wolchok, Gabrielle Rizzuto, Taha Merghoub, Deonka Huggins, Cailian Liu, Mary Jo Turk, Nicholas P. Restifo, Shimon Sakaguchi, Alan N. Houghton   +11 more
openalex   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

Enhancing Natural Killer and CD8 + T Cell-Mediated Anticancer Cytotoxicity and Proliferation of CD8 + T Cells with HLA-E Monospecific Monoclonal Antibodies [PDF]

, 2019
Cytotoxic NK/CD8+ T cells interact with MHC-I ligands on tumor cells through either activating or inhibiting receptors. One of the inhibitory receptors is CD94/NKG2A.
Asgharzadeh, Shahab, Devarajan, Asokan, Filippone, Edward J., Ravindranath, Mepur H.   +3 more
core   +1 more source

From Exciton Dynamics to Cell Fate: A Carbon Dot Based NIR Photocatalytic Platform for Pyroptosis via Self‐Trapped Excitons

Advanced Functional Materials, EarlyView.
A facile and effective method to boost NIR light induced photocatalysis based on nontoxic NIR emissive carbon dots (nir‐CDs) via Self‐trapped excitons, showing that both O2− • and •OH can be generated from nir‐CDs under NIR laser irradiation. Abstract Near‐infrared (NIR) light‐triggered photocatalytic therapy remains a critical challenge in efficient ...
Qingcheng Wang, Quansheng Cheng, Bingzhe Wang, Tesen Zhang, Yupeng Liu, Ruifeng Zheng, Shi Chen, Guichuan Xing, Songnan Qu   +8 more
wiley   +1 more source

CD40L Expression Allows CD8+ T Cells to Promote Their Own Expansion and Differentiation through Dendritic Cells

Frontiers in Immunology, 2017
CD8+ T cells play an important role in providing protective immunity against a wide range of pathogens, and a number of different factors control their activation.
Neil Q. Tay, Neil Q. Tay, Neil Q. Tay, Debbie C. P. Lee, Debbie C. P. Lee, Yen Leong Chua, Yen Leong Chua, Nayana Prabhu, Nayana Prabhu, Nicholas R. J. Gascoigne, Nicholas R. J. Gascoigne, David M. Kemeny, David M. Kemeny   +12 more
doaj   +1 more source

Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase [PDF]

, 2016
David K. Cole, Hugo A. van den Berg, Angharad Lloyd, Michael D. Crowther, Konrad Beck, Julia Makinde, John J. Miles, Anna Bulek, Garry Dolton, Andrea J. Schauenburg, Aaron Wall, Anna Fuller, Mathew Clement, Bruno Laugel, P.J. Rizkallah, Linda Wooldridge, Andrew K. Sewell   +16 more
openalex   +1 more source

Self‐Immolative Activatable Nanoassembly toward Immuno‐Photodynamic Therapy in TME

Advanced Functional Materials, EarlyView.
A quinone methide‐gated, self‐immolative, H2O2‐responsive nano‐photosensitizer (Pyz/PS) is developed for targeted immuno‐photodynamic therapy. Pyz/PS selectively activates within tumor microenvironments, restores photosensitizer activity, generates ROS, and depletes intracellular GSH, enhancing oxidative stress.
Jing Li, E Pang, Snehasish Debnath, Jia Hong, Aojun Qiu, Dongeun Kim, Goeun Kim, Minhuan Lan, Min‐Goo Lee, Qian‐Yong Cao, Jong Seung Kim   +10 more
wiley   +1 more source

Structure, function, and immunomodulation of the CD8 co-receptor

Frontiers in Immunology
Expressed on the surface of CD8+ T cells, the CD8 co-receptor is a key component of the T cells that contributes to antigen recognition, immune cell maturation, and immune cell signaling.
Shreyaa Srinivasan, Shreyaa Srinivasan, Cheng Zhu, Cheng Zhu, Andrew C. McShan   +4 more
doaj   +1 more source

CD8⁺ PD-1⁺ T-cells and PD-L1⁺ circulating tumor cells in chemotherapy-naïve non-small cell lung cancer: towards their clinical relevance? [PDF]

, 2019
Αthanasios Kotsakis, Galatea Kallergi, Despoina Aggouraki, Zaharoula Lyristi, Filippos Koinis, Eleni Lagoudaki, Anastasios Koutsopoulos, Vassilis Georgoulias, Eleni‐Kyriaki Vetsika   +8 more
openalex   +1 more source