Engineering Complexity: Advances in 3D Breast Cancer Models for Precision Oncology
Advanced Healthcare Materials, EarlyView.In vitro breast cancer models that closely mimic the complex biological and cellular interactions within the tumor microenvironment hold strong promise for enhancing our understanding of tumor progression, immune system behavior, and resistance to therapies, which are essential for developing personalized cancer treatments. Abstract Engineered in vitro
Wonwoo Jeong, Sang Jin Lee
wiley +1 more source
Fates of Commensal Specific, Innate-like CD8+ T cells in the Gut [PDF]
, 2023 Taylor K. Farley +3 more
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Harnessing Next‐Generation 3D Cancer Models to Elucidate Tumor‐Microbiome Crosstalk
Advanced Healthcare Materials, EarlyView.Centralizes the microbiome within 3D tumor‐microbiome model platforms, including spheroids, organoids, 3D‐bioprinted constructs, and microfluidic chips, each enabling structured host‐tumor‐microbe studies. These systems support bacterial colonization, facilitating investigation of microbial impacts on tumor growth, immunity, and therapy. The microbiome
Marina Green Buzhor +12 more
wiley +1 more source
Association of Cytomegalovirus DNA and Immunologic Markers of Cardiovascular Disease. [PDF]
, 2019 BackgroundPersons living with human immunodeficiency virus (HIV) (PLWH) with high cytomegalovirus (CMV)-specific interferon (IFN) γ response have increased numbers of endothelium homing receptor (CX3CR1)+-expressing cells that are associated with ...
Garg, Ankita +4 more
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Identification of a subset of microsatellite-stable endometrial carcinoma with high PD-L1 and CD8+ lymphocytes [PDF]
, 2018 Suzanne Crumley +5 more
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Synthetic Cell‐Based Tissues for Bottom‐Up Assembly of Artificial Lymphatic Organs
Advanced Healthcare Materials, EarlyView.Synthetic cells have emerged as a novel biomimetic approach for fundamental research and therapeutic interventions. T cell activating synthetic cells are able to form 3D tissue‐like structures by self‐assembly into lymphatic bottom‐up tissues (lymphBUT) with tunable biochemical and biomechanical functionalities as well as metabolic activity are ...
Anna Burgstaller +5 more
wiley +1 more source
Clinical and Translational MedicineBackground Immunotherapy has revolutionised melanoma treatment, providing significant clinical benefits by reactivating the anti‐tumour immune system. CD8+ tissue‐resident memory T lymphocytes (CD8+ TRM) have emerged as crucial mediators of anti‐tumour ...
Tianyi Zhang +19 more
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CD8 T Cell Recognition of Endogenously Expressed Epstein-Barr Virus Nuclear Antigen 1 [PDF]
, 2004 Steven P. Lee +11 more
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Hit by a Smooth CD8: T-Cell Attack on Hippocampal Neurons Triggers Limbic Encephalitis and Epilepsy
, 2021 Cynthia D. Alvarado, Amy L. Brewster
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Advances in Bioprinting to Model Immune‐Mediated Skin Diseases
Advanced Healthcare Materials, EarlyView.This review explores how 3D bioprinting drives innovation in developing in vitro skin models that mimic immune‐mediated diseases. It highlights current technologies, key applications in studying skin pathologies, and emerging challenges. The review points toward future opportunities for improving disease modeling and advancing therapeutic and cosmetic ...
Andrea Ulloa‐Fernández +4 more
wiley +1 more source