Results 131 to 140 of about 883,722 (384)

An intact signal peptide on dengue virus E protein enhances immunogenicity for CD8+ T cells and antibody when expressed from modified vaccinia Ankara [PDF]

, 2014
Dengue is a global public health concern and this is aggravated by a lack of vaccines or antiviral therapies. Despite the well-known role of CD8(+) T cells in the immunopathogenesis of Dengue virus (DENV), only recent studies have highlighted the ...
Coelho, Fabiana M., da Fonseca, Flávio G., Flesch, Inge E. A., Pinho, Tânia M. G., Quinan, Bárbara R., Tscharke, David C.   +5 more
core   +1 more source

Selective depletion and activation of CD8+ lymphocytes from peripheral blood of patients with polymyalgia rheumatica and giant cell arteritis. [PDF]

, 1989
Bhaskar DasGupta, O Duke, Anthony Timms, Costantino Pitzalis, G S Panayi   +4 more
openalex   +3 more sources

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer.

Proceedings of the National Academy of Sciences of the United States of America, 2005
In a recent report, [Zhang et al. (2003) N. Engl. J. Med. 348, 203-213], the presence of CD3+ tumor-infiltrating lymphocytes (TILs) was found to correlate with improved survival in epithelial ovarian cancer.
E. Sato, S. Olson, Jiyoung Ahn, B. Bundy, H. Nishikawa, F. Qian, A. Jungbluth, D. Frosina, S. Gnjatic, C. Ambrosone, J. Kepner, Tosin Odunsi, G. Ritter, S. Lele, Yao-Tseng Chen, H. Ohtani, L. Old, K. Odunsi   +17 more
semanticscholar   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumors

Nature, 2017
Tissue-resident memory CD8+ T (TRM) cells are found at common sites of pathogen exposure, where they elicit rapid and robust protective immune responses.
J. Milner, Clara Toma, Bingfei Yu, Kai Zhang, K. Omilusik, Anthony T. Phan, Dapeng Wang, Adam J. Getzler, Toan Nguyen, Shane Crotty, Shane Crotty, Wei Wang, M. Pipkin, A. Goldrath   +13 more
semanticscholar   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Anti-CD20 therapy depletes activated myelin-specific CD8+ T cells in multiple sclerosis. [PDF]

, 2019
CD8+ T cells are believed to play an important role in multiple sclerosis (MS), yet their role in MS pathogenesis remains poorly defined. Although myelin proteins are considered potential autoantigenic targets, prior studies of myelin-reactive CD8+ T ...
Calabresi, Peter A, Hauser, Stephen L, Sabatino, Joseph J, Schneck, Jonathan P, Wilson, Michael R, Zamvil, Scott S   +5 more
core  

Lactate Regulates Metabolic and Proinflammatory Circuits in Control of T Cell Migration and Effector Functions [PDF]

, 2015
Licensed by the Creative Commons Attribution ...
A Ene-Obong, A Lardner, AM Sidahmed, C Croia, C Gobelet, C Mauro, C Nathan, CH Chang, Claudio Mauro, Costantino Pitzalis, DK Finlay, DR Wahl, DW Jung, Elliot J. Bland, F Humby, F Vegran, Federica M. Marelli-Berg, Fulvio D’Acquisto, FW Fitch, G Yi, J Olloquequi, J Zhu, Joanne Smith, JR Doherty, K De Bock, K Fischer, KJ Livak, LZ Shi, M Buzzai, M Chabaud, M Kleinewietfeld, M Sukumar, Mauro Perretti, ME Morris, Michele Bombardieri, MJ Ovens, MM Delmastro-Greenwood, N Shyh-Chang, O Haworth, OR Colegio, Philippa Marrack, PP Hsu, R Haas, R Wang, RA Robergs, RD Michalek, Robert Haas, S Su, SJ Jarmin, SN Mueller, SP Young, SR Srinivas, SS Metkar, Suchita Nadkarni, T Hashimoto, T Hitosugi, T Montero-Melendez, T Soga, TC Leite, Trinidad Montero-Melendez, VA Gerriets, Vidalba Rocher-Ros, Y Cao   +62 more
core   +5 more sources

Instructing Memory in CD8+ Thymocytes

Trends in Immunology, 2020
T cells can sometimes acquire properties of a memory cell without encountering foreign antigen. Miller et al. now show that development of such 'memory phenotype' (MP) CD8+ T cells starts with recognition of self-ligands in the thymus, and finishes in peripheral tissues.
Kristin A. Hogquist, Katherine Maude Ashby   +1 more
openaire   +4 more sources