Results 141 to 150 of about 419,552 (297)

A Programmable Nanovaccine Platform Based on M13 Bacteriophage for Personalized Cancer Vaccine and Therapy

Advanced Materials, EarlyView.
A reprogrammed (RP) phage‐based nanovaccine platform has been developed that allows single‐step assembly with precise control over adjuvanticity, antigen density, and nanoparticle size. By enhancing TLR9 activation and neoantigen display, this platform enables a potent personalized vaccine targeting tumor‐specific neoantigens. When combined with immune
Shengnan Huang, Yanpu He, Allison Madow, Huaiyao Peng, Mirielle Griffin, Jifa Qi, Mantao Huang, Heather Amoroso, Riley Abrashoff, Nimrod Heldman, Angela M. Belcher   +10 more
wiley   +1 more source

THE ROLE OF CD8+ AND CD4+ CELLS IN REJECTION OF MULTIPLE MINOR H-DISPARATE SKIN GRAFTS

, 1989
TAKERU ICHIKAWA, Minoru Kawai, Akiko Uenaka, Hitoshi Yamamoto, Mitsukazu Gotoh, Morito Monden, TAKESADA MORI, Hiroshi Shiku, Emi E. Nakayama   +8 more
openalex   +1 more source

Peptide Coacervates with Metal–Phenolic Membranes Modulate Glucose Metabolism and Enhance Cancer Immunotherapy

Advanced Materials, EarlyView.
Peptide coacervates encapsulated with interferon‐α and membranized with metal–phenolic networks (PC‐IFNα@MPNs) are designed to reprogram glucose competition between tumor and cytotoxic T cells. This metabolic modulation enhances immunotherapy by suppressing tumor glycolysis and boosting T cell effector function.
Xin Zheng, Shiqiong Lei, Yiwei Zeng, Lian Chen, Jingqu Chen, Wei Fu, Yu Chen, Xinping Hu, Jing Wang, Meiyuan Jin, Zhichen Liu, Xiaofang Dai, Lei Liu, Wenshan He, Jiajing Zhou, Zhixing Lin, Frank Caruso, Jinghua Ren   +17 more
wiley   +1 more source

BATF and BATF3 deficiency alters CD8+ effector/exhausted T cells balance in skin transplantation

Molecular Medicine
Background It is well-established that CD8+ T-cells play a critical role in graft rejection. The basic leucine zipper ATF-like transcription factor (BATF) and BATF3 are transcriptional factors expressed in T lymphocytes.
Chenghao Li, Zongtao Liu, Zihao Wang, Wai Yen Yim, Yajun Huang, Yuqi Chen   +5 more
doaj   +1 more source

Multifunctional Bioactive Coatings Based on Bioglass, Vitamin D3, and Melittin Deposited via MAPLE for Enhanced Osseointegration, Antibacterial Activity, and Corrosion Resistance of Titanium Implants

Advanced Materials Interfaces, EarlyView.
Matrix‐Assisted Pulsed Laser Evaporation (MAPLE) technique is used to cover titanium (Ti) substrates with multifunctional bioactive coatings composed of bioglass, vitamin D3, and melittin. Coatings exhibited excellent chemical integrity and favorable micro/nanostructured morphology (promoting cellular adhesion and viability), and a sustained release of
Irina Negut, Bogdan Bita, Mihaela Dinu, Anca Constantina Parau, Tatiana Tozar, Oana Gherasim, Valentina Grumezescu, Carmen Ristoscu, Luminita Marutescu, Gratiela Gradisteanu Pircalabioru   +9 more
wiley   +1 more source

The T-cell receptor gamma chain-CD3 complex: implication in the cytotoxic activity of a CD3+ CD4- CD8- human natural killer clone. [PDF]

, 1987
Balbino Alarcón, JE de Vries, Carolyn L. Pettey, Arthur W. Boylston, Hans Yssel, Cox Terhorst, Hergen Spits   +6 more
openalex   +1 more source

Implantable Microarray Patch: Engineering at the Nano and Macro Scale for Sustained Therapeutic Release via Synthetic Biodegradable Polymers

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
This review focuses on the application of synthetic biodegradable microarray patches (MAPs) in sustained drug delivery. Compared to conventional MAPs which release drugs into the skin in an immediate manner, these implantable MAPs release drugs into skin microcirculation gradually as the biodegradable polymers degrade, thus offering sustained release ...
Li Zhao, Akmal Hidayat Bin Sabri, Mary B. McGuckin, Linlin Li, Zihao Wang, Eneko Larrañeta, Ryan F. Donnelly   +6 more
wiley   +1 more source

Class II (DR) antigen expression on CD8+ lymphocyte subsets in acquired immune deficiency syndrome (AIDS) [PDF]

, 1988
H.W.L. Ziegler-Heitbrock, Daniel Stachel, T. Schlunk, L. G�rtler, W. Schramm, M. Fr�schl, J. R. Bogner, G. Riethm�ller   +7 more
openalex   +1 more source

Multimodal Actuation and Environment Adaptive Strategies of Bio‐Inspired Micro/Nanorobots in Precision Medicine

Advanced Robotics Research, EarlyView.
An introduction for multidrive and environment‐adaptive micro/nanorobotics: design and fabrication strategies, intelligent actuation, and their applications. Various intelligent actuation approaches—magnetic, acoustic, optical, chemical, and biological—can be synergistically designed to enhance flexibility and adaptive behavior for precision medicine ...
Aiqing Ma, Han Gong, Jiacheng Ouyang, Liqi Chen, Tianfang Kang, Yiran He, Guojun Huang, Sidi Zheng, Ting Yin, Hong Pan, Lintao Cai   +10 more
wiley   +1 more source

The Roles of CD8⁺ and CD4⁺ Cells in Tumor Rejection [PDF]

, 1989
Heiichiro Udono, Masahiro Mieno, Hiroshi Shiku, Eiichi Nakayama   +3 more
openalex   +1 more source