Results 161 to 170 of about 729,582 (283)

Endometrial Cancer Suppresses CD8+ T Cell-Mediated Cytotoxicity in Postmenopausal Women [PDF]

, 2021
Mickey V. Patel, Zheng Shen, Marta Rodríguez‐García, Edward J. Usherwood, Laura J. Tafe, Charles R. Wira   +5 more
openalex   +1 more source

HERV‐K TM Subunit Elicits CD8+ T Cell Anergy and Tumor Immune Evasion via Targeting CD3 Coreceptor ε in AML and PDAC

Advanced Science, EarlyView.
Novel viral immune checkpoint K‐TM subunit is aberrantly expressed in CD8+ T cells and enriched in sera of cancer patients, inducing CD8+ T cell anergy and eliciting potent tumor immune escape in mouse model. Mechanistically, K‐TM directly targets and induces the phosphorylation of CD3ε receptor.
Mengyuan Li, Shuwen Zheng, Qinyuan Gong, Zhaoxing Wu, Wen Lei, Wanyue Cao, Ping Wang, Xuzhao Zhang, Wenbin Qian, Yun Liang, Ying Lu, Fenglin Li, Qi Zhang, Rongzhen Xu   +13 more
wiley   +1 more source

DKK3 Initially Preserves Acinar Integrity Through MEK‐Fos Signaling, but Later Switches to an Oncogenic Role in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic cancer, the protein DKK3 is found to play a complex role: it initially slows early tumor growth but later promotes tumor aggressiveness. DKK3 expression evolves during progression and drives cancer severity by orchestrating cellular and molecular signaling pathways.
Dharini Srinivasan, Elodie Roger, Lukas Perkhofer, Eleni Zimmer, Thomas F.E. Barth, Julia P. Mosler, Anna Härle, Stephanie E. Weissinger, Nadine T. Gaisa, Peter Möller, Nico Fischer, Chantal Allgöwer, J.‐Matthias Löhr, Dirk Grimm, Thomas Seufferlein, Stefan Liebau, Ninel Azoitei, Michael K. Melzer, Frank Arnold, Johann Gout, Alexander Kleger   +20 more
wiley   +1 more source

Supplemental Table 1 from mWTX-330, an IL-12 INDUKINE Molecule, Activates and Reshapes Tumor-Infiltrating CD8⁺ T and NK Cells to Generate Antitumor Immunity

, 2023
Christopher J. Nirschl, Heather R. Brodkin, Celesztina Domonkos, Connor J. Dwyer, Daniel J. Hicklin, Nesreen Ismail, Cynthia Seidel‐Dugan, Philipp Steiner, Zoe Steuert, Jenna M. Sullivan, William M. Winston, Andrés Salmerón   +11 more
openalex   +1 more source

The Pathogenic Roles of Local Vitamin D Metabolism Defect in Valve Inflammation and Calcification

Advanced Science, EarlyView.
This study identifies the valvular interstitial cell populations responsible for valvular calcification induced by hyperphosphatemia and likely aging, uncovers local vitamin D metabolism defect‐induced inflammation as a critical pathogenic factor of calcific aortic valve disease, and highlights active vitamin D and ERK inhibitor as potential preventive
Ruichen Yang, Chong Han, Yangli Xie, Shoutao Qiu, Shaoyang Zhang, Jingjia He, Zejian Wang, Zhenlin Zhang, Huijuan Liu, Lin Chen, Baojie Li   +10 more
wiley   +1 more source

Intranasal delivery of adjuvant-free peptide nanofibers elicits resident CD8+ T cell responses

, 2018
Youhui Si, Yi Wen, Sean H. Kelly, Anita S. Chong, Joel H. Collier   +4 more
openalex   +2 more sources

Cancer Immunotherapy via Disruption of Integrin αvβ3 and CD47 Costabilization on Cancer Cell Surface

Advanced Science, EarlyView.
This study identifies a cancer‐specific interaction between CD47 and integrin αvβ3 that facilitates immune evasion. A rationally designed peptide, PSFL‐NK13, disrupts this axis, enhancing macrophage‐mediated phagocytosis and suppressing tumor growth without inducing anemia.
Peng‐Cheng Yu, Chen‐Xi Yue, Wen‐Zhong Dong, Cui‐Yun Hao, Yi‐Fan Qiao, Di Liu, Xin Zhang, Qi Zhan, Jia‐Bao Yao, Dong‐Ping Wang, Peng Cao, Ying‐Zhe Fan, Ye Yu   +12 more
wiley   +1 more source

Differential Immunosuppressive Effect of 3,6-Anhydro-L-Galactose on Cytokine Production and Cell Cycle Progression of CD4 and CD8 T Cells

, 2023
Shin Young Park, Won Young Jang, Do Youn Jun, Young Ho Kim   +3 more
openalex   +1 more source

Predicting Immunotherapy Outcomes in NSCLC Using RNA and Pathology from Multicenter Clinical Trials

Advanced Science, EarlyView.
LIRA, a machine learning‐based model, is developed using transcriptomic data from 891 NSCLC patients in the OAK and POPLAR cohorts. Its predictive performance is validated in multiple external cohorts. Patients stratified by LIRA‐score exhibit distinct clinical characteristics and tumor microenvironment profiles.
Zhaojun Wang, Yiran Fang, Xiatong Huang, Guichuang Ma, Qianqian Mao, Xiansheng Lu, Guangda Rong, Yunfang Yu, Yuanyuan Wang, Zhenhua Huang, Huiying Sun, Jiani Wu, Wenchao Gu, Na Huang, Jianhua Wu, Rui Zhou, Xiaoxiang Rong, Siting Zheng, Shaowei Li, Gaofeng Wang, Ling Wang, Wenjun Qiu, Luyang Jiang, Peng Luo, Yonggang Liu, Jianping Bin, Yulin Liao, Min Shi, Zuqiang Wu, Jiguang Wang, Wangjun Liao, Gang Chen, Dongqiang Zeng   +32 more
wiley   +1 more source

Data from Expansion of Tumor-Infiltrating CD8⁺ T cells Expressing PD-1 Improves the Efficacy of Adoptive T-cell Therapy

, 2023
Sarita M. Fernández‐Poma, Diego Salas‐Benito, Teresa Lozano, Noëlia Casares, José Ignacio Riezu‐Boj, Uxua Mancheño, Edurne Elizalde, Diego Alignani, Natalia Zubeldia, Itziar Otano, Enrique Conde, Pablo Sarobe, Juan José Lasarte, Sandra Hervás‐Stubbs   +13 more
openalex   +1 more source