Results 161 to 170 of about 883,722 (384)

PD1Hi CD8+ T cells correlate with exhausted signature and poor clinical outcome in hepatocellular carcinoma

Journal of Immunotherapy for Cancer, 2019
BackgroundCD8+ T cells differentiate into exhausted status within tumors, including hepatocellular carcinoma (HCC), which constitutes a solid barrier to effective anti-tumor immunity.
Jiaqiang Ma, Bohao Zheng, S. Goswami, Lu Meng, Dandan Zhang, Chunmei Cao, Teng Li, Fangming Zhu, Lijie Ma, Zhao Zhang, Shuhao Zhang, Meng Duan, Qin Chen, Q. Gao, Xiaomin Zhang   +14 more
semanticscholar   +1 more source

Relevance of Kappa and Lambda Free Light Chains in Autoimmune Astrocytopathy Associated With Anti‐GFAP Antibodies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction The kappa‐free light chain (κ‐FLC) index is known to be highly sensitive and specific for diagnosing multiple sclerosis (MS), while little is understood about lambda (λ)‐FLC. This study assessed the κ‐FLC and λ‐FLC indices in autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy.
Michael Levraut, Romain Marignier, Mikael Cohen, Jeanne Benoit, Cassandre Landes‐Chateau, Elisabeth Maillart, Marion Cremoni, Barbara Seitz‐Polski, Anne‐Laurie Pinto, Pauline Dumez, Jérôme Honnorat, Christine Lebrun‐Frenay   +11 more
wiley   +1 more source

Differential in vitro activation of CD4+CD8- and CD8+CD4- herpes simplex virus-specific human cytotoxic T cells. [PDF]

, 1989
Masaki Yasukawa, Akira Inatsuki, Yoshiyasu KOBAYASHI   +2 more
openalex   +1 more source

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

Nature Immunology, 2020
Yanchun Peng, A. Mentzer, Guihai Liu, X. Yao, Z. Yin, D. Dong, W. Dejnirattisai, T. Rostron, P. Supasa, Chang Liu, C. López-Camacho, J. Slon-Campos, Yuguang Zhao, David I. Stuart, G. Paesen, J. Grimes, A. Antson, O. Bayfield, D. E. Hawkins, D. Ker, Beibei Wang, L. Turtle, Krishanthi S Subramaniam, Paul Thomson, Ping Zhang, C. Dold, J. Ratcliff, P. Simmonds, T. D. de Silva, P. Sopp, D. Wellington, U. Rajapaksa, Yi-Ling Chen, M. Salio, G. Napolitani, Wayne Paes, P. Borrow, B. Kessler, J. Fry, N. Schwabe, M. Semple, J. Baillie, S. Moore, P. Openshaw, M. Ansari, S. Dunachie, Ellie J. Barnes, J. Frater, G. Kerr, P. Goulder, T. Lockett, R. Levin, Yonghong Zhang, R. Jing, L. Ho, Eleanor Danning Tao Susanna John Philip Georgina Paul Guih Barnes Dong Dong Dunachie Frater Goulder Kerr Klen, Ellie J. Barnes, Tao Dong, P. Klenerman, A. McMichael, G. Ogg, M. Salio, J. Paul Alexander J. Shona C. Peter J. M. Malcolm G. Kenneth Baillie Klenerman Mentzer Moore Openshaw S, J. Kenneth Baillie, A. Mentzer, P. Openshaw, M. Semple, David I. Stuart, R. Cornall, C. Conlon, G. Screaton, J. Mongkolsapaya, J. Knight, Tao Dong   +73 more
semanticscholar   +1 more source

Clinical Characteristics of Parkinsonism in HTLV‐1‐Associated Myelopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Human T‐lymphotropic virus type 1 (HTLV‐1)‐associated myelopathy/tropical spastic paraparesis (HAM/TSP) is the classic neurological manifestation of HTLV‐1 infection; however, this virus has also been associated with other neurological disorders. Concurrent parkinsonism is relatively rare and presents diagnostic challenges.
Mika Dozono, Satoshi Nozuma, Shota Hirakata, Takashi Yoshida, Daisuke Kodama, Masakazu Tanaka, Eiji Matsuura, Ryuji Kubota, Hiroshi Takashima   +8 more
wiley   +1 more source

Coexpresión de CD4 y CD8 en linfocitos de sangre periférica en pacientes positivos para VIH Peripheral blood lymphocyte CD4 and CD8 co-expression in HIV positive patients

Infectio, 2008
Objetivo. La coexpresión en membrana de las moléculas CD4 y CD8 en leucocitos de sangre periférica se halla generalmente restringida a casos de leucemias agudas T prolinfocíticas o de leucemias T del adulto y no representa más de 3% a 5% de los ...
Alberto Gómez, Claudia González, Luz Mábel Ávila, María Consuelo Casas, Santiago Padilla   +4 more
doaj  

A virus-specific CD4+ cell-mediated cytolytic activity revealed by CD8+ cell elimination regularly develops in uncloned human antiviral cell lines. [PDF]

, 1989
I. Bourgault, Antonio Skármeta, E Gomard, Franck Picard, J P Lévy, E Gomrad   +5 more
openalex   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Class I dependence of the development of CD4+ CD8- NK1.1+ thymocytes. [PDF]

, 1994
A small subset of functionally active CD4+ CD8- thymocytes express the NK1.1 marker, as do most CD4-CD8- NK1.1+ thymocytes. Previous studies have failed to implicate a role for major histocompatibility complex (MHC) or related molecules in the selection ...
Coles, M, RAULET, David H.
core  

Patterns of costimulation of T cell clones by cross-linking CD3, CD4/CD8, and class I MHC molecules. [PDF]

, 1989
Mary C. Wacholtz, Sunil Patel, Peter E. Lipsky   +2 more
openalex   +1 more source