Results 161 to 170 of about 419,552 (297)

Nicotine Reprograms Aging‐Related Metabolism and Protects Against Motor Decline in Mice

Advanced Science, EarlyView.
Long‐term oral nicotine intake protects against age‐related motor decline in mice without eliciting systemic toxicity. Integrated multi‐organ metabolomic profiling and longitudinal gut microbiota analyses reveal that nicotine induces coordinated remodeling of glycolipid and sphingolipid metabolism, enhances NAD⁺ bioavailability, and suppresses ceramide
Shuhui Jia, Xiaoyuan Jing, Ruoxi Wang, Mengke Su, Pei Wang, Yingxin Feng, Xiaohu Ren, Longfang Tu, Ping Wei, Zhen Lu, Yicong Jia, Feng Hong, Zhizhun Mo, Jiemeng Zou, Kang Huang, Caiyun Yan, Qianhui Zou, Liang Wang, Guoping Zhong, Zhi Zeng, Qiuliyang Yu, Wen Su, Xifei Yang, Fan Pan, Jianzhi Wang, Liping Wang, Lijun Kang, Paul J. Kenny, Zuxin Chen, Xin‐an Liu   +29 more
wiley   +1 more source

CD3-T cell receptor modulation is selectively induced in CD8 but not CD4 lymphocytes cultured in agar [PDF]

, 1990
Nouflssa Oudrhiri, J P Farcet, MF Gourdin, Elisabeth Mbemba, Philippe Gaulard, A Katz, Marine Diviné, Andrew Galazka, F Reyes   +8 more
openalex   +1 more source

Tumor-draining lymph nodes respond to immune checkpoint inhibition and orchestrate tumor immune remodeling. [PDF]

Cancer Immunol Immunother
Zhang J, Ma J, Niu Y, Liu J, Wang Z, Guo J, Meng Y, Sun R, Zhang Z, Liu H, Xu J, Zan L, Guan X, Wang X.   +13 more
europepmc   +1 more source

Loss of Fibronectin Fiber Tension in Glioblastoma is Associated with Microvascular Proliferations and Immune Cell Infiltration

Advanced Science, EarlyView.
Researchers discovered that fibronectin fibers lose their tension in specific areas of glioblastoma brain tumors, accumulating in the lumen of proliferating blood vessels and in parenchyma next to infiltrating immune cell clusters. A novel molecular tension probe enables the mapping of fibronectin's fiber tension in glioblastoma for the first time ...
Michele Crestani, Isabel Gerber, Arnaud Mieville, Katrin Frauenknecht, Theoni Maragkou, Tibor Hortobagyi, Viola Vogel   +6 more
wiley   +1 more source

Leishmania-reactive CD4+ and CD8+ T cells associated with cure of human cutaneous leishmaniasis [PDF]

, 1994
Alda Maria Da‐Cruz, Fátima Conceição‐Silva, Álvaro Luiz Bertho, S. G. Coutinho   +3 more
openalex   +1 more source

The role of TCF-1+CD8+ exhausted progenitors and TCF-1 in graft-versus-host responses. [PDF]

JCI Insight
Quann K, Sacirbegovic F, Rosenberger S, McFerran ER, Codispot KC, Garcia-Dieguez L, Rowe AM, Wei W, Jain D, McNiff JM, Shlomchik W.   +10 more
europepmc   +1 more source

Steroid Receptor Coactivator‐1 Drives Tumor‐Associated Macrophage Reprogramming by Mediating MMP12 Transcription in Pancreatic Cancer Perineural Invasion

Advanced Science, EarlyView.
Steroid receptor coactivator‐1 (SRC‐1) reprograms tumor‐associated macrophages (TAMs) via signal transducer and activator of transcription 1(STAT1)‐mediated matrix metallopeptidase 12 (MMP12) transcription to drive perineural invasion (PNI) in pancreatic cancer.
Ke Cheng, Liang Liu, Miaomiao Gong, Yuke Ji, Chunmei Bai, Xiangqian Guo, Hui Chen, Jinjin Pan, Ying Zhang, Yuhui Yuan   +9 more
wiley   +1 more source

A Dual Role for NKG7 in T-cell Cytotoxicity and Longevity. [PDF]

Cancer Immunol Res
Dong H, Ham H, Barham W, Wen T, Hirdler JB, Mao Z, Ashton DS, Zhang W, Lucien-Matteoni F, Borges da Silva H, Billadeau DD.   +10 more
europepmc   +1 more source

Cuproptosis Signature Would Reveal the Acute‐Remitting Pattern in Patients with Neuromyelitis Optica Spectrum Disorder

Advanced Science, EarlyView.
Neuromyelitis optica spectrum disorder (NMOSD) has distinct acute‐remitting courses but lacks biomarkers for predicting relapse. Recent studies found cuproptosis‐related genes affect its course, and a model built accordingly can predict relapse to aid intervention.
Peidong Liu, Ruoyu Li, Xinlin Wang, Hui Li, Huiru Hu, Ang Shen, Wenping Zhu, Jiali Pan, Yanmeng Xing, Weiming Xia, Henan Jiao, Di Chen, Lixin Wu, Li Liu, Ju Liu, Bin Yu, Xianzhi Liu, Hongbo Liu   +17 more
wiley   +1 more source

Feline immunodeficiency virus infects both CD4+ and CD8+ T lymphocytes [PDF]

, 1991
Wendy C. Brown, Lynda LeDawn Bissey, Kathleen Logan, Niels C. Pedersen, John H. Elder, Ellen W. Collisson   +5 more
openalex   +1 more source