Results 181 to 190 of about 419,552 (297)

Differentiation and mitochondrial metabolic characteristics of CD8⁺ T cells in malignant ascites of epithelial ovarian cancer and their correlation with estrogen signaling. [PDF]

Cancer Immunol Immunother
Jiang Z, Zhou Y, Wu J, Shen Y, Tang D, Wu Y, Qu Q, Wang J.   +7 more
europepmc   +1 more source

Lifespan‐Regulated CAR‐Macrophages from Myeloid Progenitors for Enhanced Colorectal Cancer Therapy

Advanced Science, EarlyView.
Using a tamoxifen‐inducible Hoxb8 system, proliferative bone marrow progenitors can be generated, which are subsequently engineered with an anti‐CEA CAR construct containing a suicide gene (iCas9) and differentiated into CAR‐macrophages. This method facilitates scale up the production of CAR‐macrophages.
Chuancheng Gao, Fangling Hong, Yao Dong, Yong Fu, Yunong Ma, Xuedi Sun, Junfeng Zhang, Jiangning Chen, Zhen Huang   +8 more
wiley   +1 more source

IFN-alpha 1 gene expression into a metastatic murine adenocarcinoma (TS/A) results in CD8+ T cell-mediated tumor rejection and development of antitumor immunity. Comparative studies with IFN-gamma-producing TS/A cells. [PDF]

, 1994
Maria Ferrantini, Mirella Giovarelli, Alessandra Modesti, Piero Musiani, A Modica, Massimo Venditti, E Peretti, Pier‐Luigi Lollini, Patrizia Nanni, G Forni   +9 more
openalex   +1 more source

CD8⁺ TILs in necrotic tumors after neoadjuvant immunochemotherapy predict outcomes in non-small-cell lung cancer patients. [PDF]

Signal Transduct Target Ther
Lin H, Han Y, Guo L, Liu C, Li H, Li J, Wang C, Zhou L, Zhang X, Sun L, Zhang YY, Chu X, Shi J, Cao X, Chen Y, Qin Z, Bao J, Wan S, Chen H, Tang X, Li X, Wang X, Cheng Y, Li Y, Zhang J, Liu C, Zhang X, Wang Y, Hu Y, Che N, Xu X, Lu H.   +31 more
europepmc   +1 more source

The CXCL10‐CXCR3 Axis Induces Tumor‐Associated Neutrophils to Interfere with CTLs‐Mediated Antitumor Activity in EBV‐Associated Epithelial Cancers

Advanced Science, EarlyView.
Compared with EBV‐negative epithelial cancer cells, EBV‐associated epithelial cancer cells exhibit enhanced secretion of chemokines, including CXCL10 and CCL5, to attract neutrophils. Via the CXCL10‐CXCR3 axis‐mediated positive feedback loop, neutrophils within EBV‐associated epithelial cancer cells are induced to form abundant NETs, which facilitate ...
Dijun Ouyang, Tong Xiang, Yuanyuan Chen, Mengjia Song, Jingjing Zhao, Hao Chen, Si Li, Lifeng Zhang, Chi Xu, Yan Ren, Yong Tao, Qijing Wang, Jia He, Yongqiang Li, Sisi Xie, Yuanyuan Liu, Yan Wang, Xinyi Yang, Jinqi You, Songzuo Xie, Yingzi Li, Desheng Weng, Qiuzhong Pan, Qi Yang, Jianchuan Xia   +24 more
wiley   +1 more source

Stress induces corticosterone-mediated CD8⁺ T cell exhaustion to promote non-small cell lung cancer. [PDF]

Cancer Immunol Immunother
Zheng Q, Zhuoga J, Weng Q, Zhang H, Deng L, Yalikun M, Fu P, Dong Z, Dong J.   +8 more
europepmc   +1 more source

Advanced Microfluidics for Single Cell‐Based Cancer Research

Advanced Science, EarlyView.
Cutting‐edge microfluidic platforms are transforming single‐cell cancer research. This review highlights advanced technologies, from droplet microfluidics to tumour‐chips, that enable functional and spatial single‐cell analyses. By integrating biosensing, immune components, and patient‐derived materials, these systems offer new insights into tumour ...
Adriana Carneiro, Marta Aranda Palomer, Margarida Esteves, Carolina Rodrigues, José Maria Fernandes, Francisca Oliveira, Alexandra Teixeira, Carlos Honrado, Lorena Dieguez, Sara Abalde‐Cela, Miguel Xavier   +10 more
wiley   +1 more source

Dynamic adhesion of CD8-positive cells to antibody-coated surfaces: the initial step is independent of microfilaments and intracellular domains of cell-binding molecules. [PDF]

, 1994
A Pierres, O. Tissot, Bernard Malissen, Pierre Bongrand   +3 more
openalex   +1 more source

CD103^-CD8⁺ T cells promote neurotoxic inflammation in Alzheimer's disease via granzyme K-PAR-1 signaling. [PDF]

Nat Commun
Terrabuio E, Pietronigro EC, Bani A, Della Bianca V, Laudanna C, Rossi B, Finotti G, Santos-Lima B, Zenaro E, Turano E, Tosadori G, Calgaro M, Vitulo N, Castellucci M, Cecconi D, Brandi J, Vareltzakis N, Mainieri F, Calore A, Angelini G, Bonetti B, Constantin G.   +21 more
europepmc   +1 more source

Osteoblast‐CD4+ CTL Crosstalk Mediated by SIRT1/DAAM2 Axis Prevents Age‐Related Bone Loss

Advanced Science, EarlyView.
In the osteoblastic niche, SIRT1 activates and recruits CD4+ CTLs by increasing DAAM2 expression via EZH2 deacetylation and boosting the secretion of key chemokines, such as CCL3, CCL5, and CXCL10. Then, CD4+ CTL directly eliminates senescent osteoblasts in an MHC‐II‐dependent way, thereby slowing down the process of bone ageing and effectively ...
Bin Yang, Guofu Zhang, Yizhou Zhu, Jingcheng Wang, Xinmin Feng, Wenyong Fei, Jihang Dai, Le Hu, Yi Zhang, Jun Cai, Binjia Ruan, Yue Jin, Fanhao Wei, Gang Lu, Dongan Wang, Jason Pui Yin Cheung, Graham Ka Hon Shea, Hao Chen, Kelvin Wai Kwok Yeung, Lei Wang, Yongxiang Wang   +20 more
wiley   +1 more source