Results 251 to 260 of about 436,454 (294)

Toll like receptor agonist effects on human CD8+ T cell activation and expression of T cell checkpoint receptors. [PDF]

Hum Vaccin Immunother
Jeon D, Moseman JE, Hill E, McNeel DG.
europepmc   +1 more source

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

Advanced Science, EarlyView.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang   +14 more
wiley   +1 more source

Comparative analysis of malignant pleural effusion and peripheral blood reveals unique T cell signatures associated with survival in mesothelioma patients. [PDF]

Oxf Open Immunol
Principe N, Stevens KLP, Phung AL, McCoy M, Kidman J, Ismail A, Cook AM, Chopra A, Watson M, Robinson BW, Creaney J, Lee YCG, Waithman J, Lesterhuis WJ, Lake RA, Nowak AK, Chee J, McDonnell AM.   +17 more
europepmc   +1 more source

Intravital imaging of the formation and resolution of MHC class II-positive T-cell activation niches. [PDF]

Life Sci Alliance
Oleksyn D, Miller J.
europepmc   +1 more source

Table 1_Immune cell communication networks and memory CD8+ T cell signatures sustaining chronic inflammation in COVID-19 and Long COVID.xlsx

Hengrui Liu (2059750), Zewen Xu (1365240), Ilayda Karsidag (22473481), Panpan Wang (228835), Jieling Weng (12221582)   +4 more
openalex   +1 more source

Terminally exhausted CD8⁺ T cells in solid tumors: biology, biomarker potential and translational tools for precision oncology. [PDF]

Front Immunol
Guo X, Ma S, Wang J, Fu Y, Ma W.
europepmc   +1 more source

CXCR6 promotes dermal CD8+ T cell survival and transition to long-term tissue residence. [PDF]

J Immunol
Heim TA, Ibrahim O, Lin Z, Schultz AC, Steele MM, Mudianto T, Lund AW.   +6 more
europepmc   +1 more source

LSD1 Inhibition Induces MHC-I and Dendritic Cell Activation to Promote Antitumor Immunity in Head and Neck Squamous Cell Carcinoma. [PDF]

Cancer Res
Chakraborty AK, Kroehling L, Raut RD, Choudhury C, Kukuruzinska MA, Gutkind JS, Varelas X, Sahay B, Monti S, Bais MV.   +9 more
europepmc   +1 more source

Possible Involvement of Skin-Resident Memory T Cells in Refractory Chronic Alopecia Areata. [PDF]

Exp Dermatol
Kageyama R, Ito T, Kurihara K, Fujiyama T, Honda T.   +4 more
europepmc   +1 more source