Results 251 to 260 of about 922,724 (383)

CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions.

Annual Review of Medicine, 2018
M. Hashimoto, A. Kamphorst, S. Im, H. Kissick, R. Pillai, S. Ramalingam, K. Araki, R. Ahmed   +7 more
semanticscholar   +1 more source

CYP4X1/sEH‐Dependent Endocannabinoid Metabolism Drives Fibroblast‐Mediated Immunosuppression to Limit Immunotherapy in Colon Cancer

Advanced Science, EarlyView.
A proposed mechanism to explain the role of CYP4X1/sEH‐14,15‐EET‐EA system in colon cancer immune escape. 14,15‐EET‐EA, 14,15‐epoxyeicosatrienoic acid‐ethanolamide; sEH, soluble epoxide hydrolase; CYP4X1, cytochrome P450 4X1; GPR119, G‐protein coupled receptor 119; EGFR, epidermal growth factor receptor; Gs, Gαs subunit; cAMP, cyclic adenosine ...
Min Mo, Xuewei Chen, Yanzhuo Liu, Chenlong Wang, Xuehan Chen, Nan Zhang, Nan He, Ying Li, Jingyi Wang, Honglei Chen, Jing Yang   +10 more
wiley   +1 more source

Chimeric MHC class I- and II-restricted non-self epitopes broaden antitumor T cell reactions. [PDF]

J Exp Med
Zhang R, Ma R, Leong MML, Watson IR, Iida K, Yaguchi T, Matsuda F, Honjo T, Chamoto K.   +8 more
europepmc   +1 more source

The role of the CD8 co-receptor in CD8+ T-cell activation [PDF]

CD8+ T-cells are essential for the immune control of pathogens and the natural eradication of\ud cancer. CD8+ T-cells also play a major role in the pathogenesis of autoimmunity and\ud alloreactivity. CD8+ T-cells recognize short peptide fragments (8-13 amino acids) presented\ud at the target cell surface bound to Major Histocompatability Class I (MHCI)
openaire  

Single‐Cell Transcriptome Atlas Reveals the Underlying Mechanism of Kynurenic Acid in the Regulation of Tumor Immune Microenvironment in Glioblastoma

Advanced Science, EarlyView.
KYNA regulates the tumor immune microenvironment in glioblastoma. KYNA reprograms the balance between T cell exhaustion and activation to suppress glioblastoma progression through inhibiting exhaustion‐associated markers (such as PD‐1, LAG3, and TOX) and enhancing immune activation and cytotoxicity markers including granzymes GZMA and GZMB.
Di Chen, Liming Sun, Jiajun Chen, Zi Ye, Xuqiang Zhu, Hongjiang Li, Lixin Wu, Guohua Zhao, Qinghao Zhang, Guangyi Jiang, Yuchen Ji, Yake Xue, Hongwei Li, Ruokun Chen, Hongwei Zheng, Rong Zeng, Dongming Yan, Yong Zhang, Xueyuan Li, Jing Yan   +19 more
wiley   +1 more source

SOAT1 in ovarian cancer cells regulates immune response mediated by CD8⁺ T cells. [PDF]

J Ovarian Res
He J, Siu MKY, Long R, Hung L, Zhang R, Yung MMH, Lu H, Ngan HYS, Chan KKL.   +8 more
europepmc   +1 more source

NKG2D ligand expression in Crohn's disease and NKG2D-dependent stimulation of CD8+ T cell migration

, 2017
Kasper Vadstrup, Elisabeth D. Galsgaard, Helle Jensen, Lewis L. Lanier, James C. Ryan, Shih‐Yu Chen, Garry P. Nolan, Marianne Kajbæk Vester-Andersen, Julie Steen Pedersen, Jens Gerwien, Teis Jensen, Flemming Bendtsen   +11 more
openalex   +2 more sources

Interleukin-21 Induces Short-Lived Effector CD8 ⁺ T Cells but Does Not Inhibit Their Exhaustion after Mycobacterium bovis BCG Infection in Mice [PDF]

, 2018
Naoto Noguchi, Risa Nakamura, Shinya Hatano, Hisakata Yamada, Xun Sun, Naoya Ohara, Yasunobu Yoshikai   +6 more
openalex   +1 more source

IPGCA: A Comprehensive Single Cell Atlas of 1 074 127 Porcine Intestinal Cells Revealing Cellular Dynamics, Genetic Regulation, and Cross‐Species Conservation

Advanced Science, EarlyView.
A high resolution integrated cell atlas of the pig intestine provides insights into the genetic mechanisms of complex traits (Created in BioRender. Yu, P. (2025) https://BioRender.com/o14c563) Abstract The porcine intestinal tract is vital for nutrient absorption, immune regulation, and various physiological processes.
Pengfei Yu, Qinqin Xie, Xiaodian Cai, Zhanming Zhong, Ran Wei, He Han, Shuang Liu, Zhenyang Zhang, Lingyao Xu, Zitao Chen, Zhe Zhang, Qishan Wang, Yuchun Pan, Zhen Wang, Zhe Zhang   +14 more
wiley   +1 more source

IL-10- and IL-13-Biased T Cell Responses to SARS-CoV-2 Vaccination in Diabetes. [PDF]

Eur J Immunol
Jones EM, Sourij C, Stradner M, Schlenke P, Sereban N, Moser O, Quinlan R, Short CE, Harris BHL, Fertleman M, Taylor GP, Oliver N, Sourij H, Dominguez-Villar M.   +13 more
europepmc   +1 more source