Results 41 to 50 of about 883,722 (384)

Precommitment of CD4+CD8+ thymocytes to either CD4 or CD8 lineages. [PDF]

Proceedings of the National Academy of Sciences, 1993
CD4+ and CD8+ mature T cells arise from CD4+CD8+ precursors in the thymus. During this process, cells expressing T-cell receptors (TCRs) reactive with self major histocompatibility complex (MHC) class I or II molecules are positively selected to the CD8 or CD4 lineage, respectively.
Crompton, Tessa, Lees, Rosemary K., Pircher, Hanspeter, Macdonald, Heather Robson   +3 more
openaire   +4 more sources

Prostaglandin E2 promotes features of replicative senescence in chronically activated human CD8+ T cells. [PDF]

, 2014
Prostaglandin E2 (PGE2), a pleiotropic immunomodulatory molecule, and its free radical catalyzed isoform, iso-PGE2, are frequently elevated in the context of cancer and chronic infection.
Chou, Jennifer P, Effros, Rita B, Koduri, Megha P, Ramirez, Christina M, Ryba, Danielle M   +4 more
core   +9 more sources

Splenic CD8(+) T cells secrete TGF-beta 1 to exert suppression in mice with anterior chamber-associated immune deviation [PDF]

, 2009
Background CD8(+) regulatory T cells (Treg) have been considered to be involved in a model of ocular-induced tolerance, known as anterior chamber-associated immune deviation (ACAID).
He, H., Huang, X.K., Jiang, L.Q., Kijlstra, A., Lin, X.M., Yang, P.Z., Zhou, H.Y.   +6 more
core   +2 more sources

TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

Nature, 2019
Exhausted CD8+ T (Tex) cells in chronic infections and cancer have limited effector function, high co-expression of inhibitory receptors and extensive transcriptional changes compared with effector (Teff) or memory (Tmem) CD8+ T cells.
O. Khan, Josephine R. Giles, Sierra J. McDonald, Sasikanth Manne, S. Ngiow, K. P. Patel, Michael T. Werner, Alexander C. Huang, Katherine A Alexander, Jennifer E. Wu, John Attanasio, P. Yan, Sangeeth M. George, B. Bengsch, Ryan P. Staupe, G. Donahue, W. Xu, R. Amaravadi, Xiaowei Xu, G. Karakousis, T. Mitchell, L. Schuchter, J. Kaye, S. Berger, E. Wherry   +24 more
semanticscholar   +1 more source

CD8+ CD28− and CD8+ CD57+ T cells and their role in health and disease

Immunology, 2011
Chronic antigenic stimulation leads to gradual accumulation of late-differentiated, antigen-specific, oligoclonal T cells, particularly within the CD8(+) T-cell compartment. They are characterized by critically shortened telomeres, loss of CD28 and/or gain of CD57 expression and are defined as either CD8(+) CD28(-) or CD8(+) CD57(+) T lymphocytes ...
Marius Strioga, Dainius Characiejus, Vita Pasukoniene   +2 more
openaire   +4 more sources

Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1. [PDF]

, 2017
The expansion of CD8+CD28- T cells, a population of terminally differentiated memory T cells, is one of the most consistent immunological changes in humans during aging.
Fei, Mingjian, Gordon, David E, Hull, Philip A, Jeng, Mark Y, Johnson, Jeffrey, Kasler, Herb, Krogan, Nevan, Kwon, Hye-Sook, Ng, Che-Ping, Ott, Melanie, Tsou, Chia-Lin, Verdin, Eric   +11 more
core   +1 more source

Activation or exhaustion of CD8+ T cells in patients with COVID-19

Cellular & Molecular Immunology, 2021
In addition to CD4+ T cells and neutralizing antibodies, CD8+ T cells contribute to protective immune responses against SARS-CoV-2 in patients with coronavirus disease 2019 (COVID-19), an ongoing pandemic disease.
M. Rha, E. Shin
semanticscholar   +1 more source

Transnuclear CD8 T cells specific for the immunodominant epitope Gra6 lower acute-phase Toxoplasma gondii burden. [PDF]

, 2016
We generated a CD8 T-cell receptor (TCR) transnuclear (TN) mouse specific to the Ld -restricted immunodominant epitope of GRA6 from Toxoplasma gondii as a source of cells to facilitate further investigation into the CD8 T-cell-mediated response against ...
Blanchard, Nicolas, Dougan, Stephanie K, Frickel, Eva-Maria, Jackson, John, Ploegh, Hidde, Sanecka, Anna, Shastri, Nilabh, Yoshida, Nagisa   +7 more
core   +2 more sources

Clinical relevance of tumor infiltrating lymphocytes, PD-L1 expression and correlation with HPV/p16 in head and neck cancer treated with bio- or chemo-radiotherapy

OncoImmunology, 2017
To investigate the prognostic value of tumor infiltrating lymphocytes (TILs: CD8+ and FoxP3+), and PD-L1 expression in patients with head and neck squamous cell carcinoma (HNSCC) treated with radiotherapy combined with cisplatin (CRT) or cetuximab (BRT).
Dan Ou, Julien Adam, Ingrid Garberis, Pierre Blanchard, France Nguyen, Antonin Levy, Odile Casiraghi, Philippe Gorphe, Ingrid Breuskin, François Janot, Stephane Temam, Jean-Yves Scoazec, Eric Deutsch, Yungan Tao   +13 more
doaj   +1 more source

Immune surveillance activation after neoadjuvant therapy for esophageal adenocarcinoma and complete response

OncoImmunology, 2020
After neoadjuvant chemoradiotherapy for esophageal adenocarcinoma, up to 29% of patients have a pathological complete response (pCR). What to do afterward is still under debate.
Andromachi Kotsafti, Melania Scarpa, Francesco Cavallin, Matteo Fassan, Roberta Salmaso, Andrea Porzionato, Luca Saadeh, Matteo Cagol, Rita Alfieri, Carlo Castoro, Massimo Rugge, Ignazio Castagliuolo, Marco Scarpa   +12 more
doaj   +1 more source