Results 41 to 50 of about 729,582 (283)

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

A Study to Delineate the Immunohistological Parameters of Active Versus Stable Vitiligo Using S100, Melan A in Conjunction with CD4 and CD8 Immunohistochemistry Markers

Indian Dermatology Online Journal
Background: Vitiligo is an autoimmune pigmentary disorder where it is important to assess the disease status (active/stable) to guide therapeutic decisions.
Sai Jyoti, Minakshi Bhardwaj, Savitha Sharath, Kabir Sardana, Pooja Arora   +4 more
doaj   +1 more source

Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes [PDF]

, 1990
Although the relative contribution of different immune effector functions to clearing tissues of cytomegalovirus is controversial, the contribution of CD8+ T lymphocytes has generally been accepted as essential. In this report, we show that under certain
Jonjic, Stipan, Koszinowski, Ulrich H., Lucin, Pero, Pavic, Ivica, Rukavina, Daniel   +4 more
core  

A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells [PDF]

, 2007
Viral mutational escape can reduce or abrogate recognition by the T cell receptor (TCR) of virus-specific CD8+ T cells. However, very little is known about the impact of cytotoxic T lymphocyte (CTL) epitope mutations on interactions between peptide–major
Allen, R, Allen, TM, Allgaier, R, Altfeld, M, Feeney, M, Gandhi, RT, Kavanagh, DG, Lichterfeld, M, Miura, T, Moza, B, Mui, SK, Pereyra, F, Rosenberg, ES, Sivamurthy, R, Sundberg, EJ, Trocha, A, Walker, BD, Williams, KL, Yu, XG   +18 more
core   +3 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

HTLV-1 Proliferation after CD8+ Cell Depletion by Monoclonal Anti-CD8 Antibody Administration in Latently HTLV-1-Infected Cynomolgus Macaques

Microbiology Spectrum, 2023
Human T-cell leukemia virus type 1 (HTLV-1) induces chronic asymptomatic latent infection with a substantial proviral load but without significant viral replication in vivo.
Midori Nakamura-Hoshi, Takushi Nomura, Masako Nishizawa, Trang Thi Thu Hau, Hiroyuki Yamamoto, Midori Okazaki, Hiroshi Ishii, Kenzo Yonemitsu, Yuriko Suzaki, Yasushi Ami, Tetsuro Matano   +10 more
doaj   +1 more source

Effect Of Mangosteen (Garcinia Mangostana) Peel Extract Towards CD8 + T Lymphocytes And CD8 + CD38 Expression In HIV Patients With Antiretroviral Therapy [PDF]

, 2015
Background : HIV/AIDS still being an emerging disease and the AIDS epidemic in Indonesia is one of the fastest growing in Asia. Humans infected with HIV have been shown to be under chronic oxidative stress.
Komala, Ika
core  

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Avidity of influenza-specific memory CD8+ T-cell populations decays over time compromising antiviral immunity [PDF]

, 2012
Decline of cell-mediated immunity is often attributed to decaying T-cell numbers and their distribution in peripheral organs. This study examined the hypothesis that qualitative as well as quantitative changes contribute to the declining efficacy of CD8+
Alexander-Miller, Almeida, Appay, Berger, Betts, Bosselut, Cerundolo, Gallimore, Gorman, Hansen, Hollander, Homann, Jelley-Gibbs, Jenkins, Jones, Jones, Judge, Karrer, Kattan, Kedzierska, Kim, Kohlmeier, Lefranc, Liang, Moffat, Neveu, Norbury, Powell, Price, Quigley, Rangel-Moreno, Richards, Roberts, Schluns, Tan, Tough, Trautmann, Valkenburg, Valkenburg, Woodland, Wooldridge, Zammit   +41 more
core   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source