Results 171 to 180 of about 93,479 (280)

TLR9 Inhibition Shortly After Mating Increases Fetal Resorption and Alters B- and T-Cell Costimulatory Phenotypes in an Abortion-Prone Mouse Model. [PDF]

Int J Mol Sci
Lorek D, Kedzierska AE, Slawek A, Kubik P, Chelmonska-Soyta A.   +4 more
europepmc   +1 more source

Engineered Bacteria‐Vesicle Delivered Lactate Reprogramming Boosts Tumor Radiosensitivity

Advanced Science, EarlyView.
We engineered a bacterial‐vesicular dual‐delivery platform that targets LOx to colorectal tumors, enabling lactate clearance, immune microenvironment remodeling, and microbiota modulation. This microbe–metabolism synergistic strategy effectively sensitizes colorectal cancer to radiotherapy, offering a promising approach to overcome radioresistance ...
Fei Peng, Zhe Lei, Zhehao Zhang, Zhiyue Su, Chonghai Zhang, Huan Yang, Shu Liu, Mengyuan Hu, Yuhong Wang, Lingchuan Guo, Lin Hu, Kai Yang   +11 more
wiley   +1 more source

CD28-mediated linear and parallel costimulatory signaling cooperatively regulate CAR-T cell functions via CAR-CD28 microclusters. [PDF]

Commun Biol
Nishikawa T, Takeuchi A, Machiyama H, Wakamatsu E, Nishijima H, Furuhata M, Toyota H, Nishi W, Matsushima R, Yoshida Y, Harada K, Yokosuka T.   +11 more
europepmc   +1 more source

Macrophage Phenotype Detection Methodology on Textured Surfaces via Nuclear Morphology Using Machine Learning

Advanced Intelligent Discovery, EarlyView.
A novel machine learning approach classifies macrophage phenotypes with up to 98% accuracy using only nuclear morphology from DAPI‐stained images. Bypassing traditional surface markers, the method proves robust even on complex textured biomaterial surfaces. It offers a simpler, faster alternative for studying macrophage behavior in various experimental
Oleh Mezhenskyi, Kateryna Andriienkova, Tetyana Goldanova, Ezgi Antmen, Thibaut Soubrie, Nihal Engin Vrana   +5 more
wiley   +1 more source

Enhancing the tumoricidal efficacy of the nanobubbles-mediated PD-L1 inhibition and immunogenic cell death in mice. [PDF]

Front Immunol
Liu Y, Han J, Liu C, Chen Y, Yang S, Ma Y, Zhou C, Liu R, Hu Y, Zhao Y.   +9 more
europepmc   +1 more source

Confined B‐Cell Reconstruction and High T‐Cell Clonality Define Clinical Response to Cladribine Treatment

Annals of Neurology, EarlyView.
Cladribine tablets are approved for relapsing multiple sclerosis, mediating their clinical effect by moderately depleting lymphocytes. In a prospective, monocentric study including 22 patients completing 2 annual cycles of cladribine, B‐ and T‐cell receptor repertoires and relapse activity were assessed at baseline and after 24 months. T‐cell clonality
Tilman Schneider‐Hohendorf, Maria Eveslage, Timo Wirth, Christian Wünsch, Eva M. Schumann, Jan D. Lünemann, Heinz Wiendl, Luisa Klotz, Nicholas Schwab   +8 more
wiley   +1 more source

<i>Fusobacterium nucleatum</i> drives CD40-mediated dendritic cell activation and Th17/Treg imbalance to exacerbate intestinal inflammation in Crohn's disease. [PDF]

Front Immunol
Wang M, Sun J, Yu J, Wang J, Xu C, Ma J, Zhang H.   +6 more
europepmc   +1 more source

Mannose‐Modified Cationic Liposome‐Based mRNA Therapeutics for Improved Triple‐Negative Breast Cancer Immunotherapy

Advanced NanoBiomed Research, EarlyView.
Schematic illustration of mTEM8‐loaded cationic liposome (cLipo‐Man/mTEM8) therapeutics for improved triple‐negative breast cancer immunotherapy. Despite triple‐negative breast cancer (TNBC) is the most heterogeneous and aggressive subtype of breast cancer, immunotherapy is emerging as a promising therapy.
Kexin Deng, Juping Sun, Junyu Liu, Yuqi Zhang, Wanwan Liu, Xiaobin Li, Han Wu, Juan Li, Jisong Zhang, Chanyuan Jin, Can Yang Zhang   +10 more
wiley   +1 more source

Repeated Mesenchymal Stem Cell Delivery Attenuates UHMWPE Wear Particle-Induced Osteolysis by Paracrine-Mediated Macrophage Reprogramming. [PDF]

J Inflamm Res
Ding K, Fan D, Dong A, Ma C, Zeng T, Huang Z, Yang Y, Song K.   +7 more
europepmc   +1 more source

Serum Proteomic Signatures of RA Risk and Response: Analysis of the APIPPRA Trial

Arthritis &Rheumatology, Accepted Article.
Objective To identify serum protein signatures associated with progression to rheumatoid arthritis (RA) and response to abatacept in at‐risk individuals. Methods A total of 440 serum samples from 118 APIPPRA study participants were selected from baseline to RA onset for 46 RA progressors or to study end for 72 participants who did not develop RA ...
Marianna Jasenecova, Carl Coyle, Alina Mihalovits, Sarah Ryan, Elizabeth Pook, Esperanza Perucha, Gabrielle Harker, Melody Chin, Sam Norton, Andrew P. Cope   +9 more
wiley   +1 more source