Results 11 to 20 of about 411,131 (265)
CD8+ T Cells in Atherosclerosis [PDF]
Cells, 2020 Atherosclerotic lesions are populated by cells of the innate and adaptive immune system, including CD8+ T cells. The CD8+ T cell infiltrate has recently been characterized in mouse and human atherosclerosis and revealed activated, cytotoxic, and possibly
Sarah Schäfer, Alma Zernecke
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The Scientific World Journal, 2012 As many members of the tumor necrosis factor receptor superfamily, glucocorticoid-induced TNFR-related gene (GITR) plays multiple roles mostly in the cells of immune system.
Simona Ronchetti +3 more
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CD8+ T Cell Exhaustion in Cancer [PDF]
Frontiers in Immunology, 2021 A paradigm shift in the understanding of the exhausted CD8+ T cell (Tex) lineage is underway. Originally thought to be a uniform population that progressively loses effector function in response to persistent antigen, single-cell analysis has now revealed that CD8+ Tex is composed of multiple interconnected subpopulations.
Joseph S. Dolina +3 more
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Stem-like CD8+ T cells in cancer
Frontiers in ImmunologyStem-like CD8+ T cells (TSL) are a subset of immune cells with superior persistence and antitumor immunity. They are TCF1+ PD-1+ and important for the expansion of tumor specific CD8+ T cells in response to checkpoint blockade immunotherapy.
Chelsea Steiner +3 more
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CD8 T cell quiescence revisited [PDF]
Trends in Immunology, 2012 Naïve T cells are typically considered to be in a default state of quiescence, whereas memory T cells undergo basal proliferation and quickly exhibit effector responses when stimulated. Over the past few years, however, a more complex picture has emerged, with evidence that naïve T cell quiescence is actively enforced, and that heterogeneity among ...
Sara E, Hamilton, Stephen C, Jameson
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A brief history of CD8 T cells [PDF]
European Journal of Immunology, 2007 CD8 T cells comprise a powerful branch of the adaptive immune system, yet were not formally recognized until long after the discovery of antibody. CD8 T cells contribute to the eradication of intracellular infections and to the control of many chronic infections.
David, Masopust +3 more
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The Timing of Stimulation and IL-2 Signaling Regulate Secondary CD8 T Cell Responses. [PDF]
PLoS Pathogens, 2015 Memory CD8 T cells provide protection to immune hosts by eliminating pathogen-infected cells during re-infection. While parameters influencing the generation of primary (1°) CD8 T cells are well established, the factors controlling the development of ...
Shaniya H Khan +5 more
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Journal for ImmunoTherapy of Cancer, 2021 Background Chemokine (C-X-C motif) ligand 13 (CXCL13) was known as a selective chemotaxis for B cells, a product of follicular helper CD4+T cells (TFH) and a contributor to tertiary lymphoid structures (TLS).
Jiejie Xu +16 more
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Cancer immunosurveillance by CD8 T cells [PDF]
F1000Research, 2020 Clinical success attained in patients with cancer treated with checkpoint inhibitors has renewed the interest in the immune system and in particular in T cells as a therapeutic tool to eliminate tumors. Here, we discuss recent studies that evaluate the anti-tumor role of CD8 T cells and the mechanisms that interfere with this function.
José C. Crispín, George C. Tsokos
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CD8+ T regulatory cells in lupus [PDF]
Rheumatology and Immunology Research, 2021 Abstract T regulatory cells (Tregs) have a key role in the maintenance of immune homeostasis and the regulation of immune tolerance by preventing the inflammation and suppressing the autoimmune responses. Numerical and functional deficits of these cells have been reported in systemic lupus erythematosus (SLE) patients and mouse models of
Singh, Ram P. +2 more
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