Results 21 to 30 of about 14,245,224 (307)

Dual function of the NK cell receptor 2B4 (CD244) in the regulation of HCV-specific CD8+ T cells [PDF]

, 2011
The outcome of viral infections is dependent on the function of CD8+ T cells which are tightly regulated by costimulatory molecules. The NK cell receptor 2B4 (CD244) is a transmembrane protein belonging to the Ig superfamily which can also be expressed ...
Lunemann, Sebastian, Bektas, Hueseyin, Heiner Wedemeyer, Wedemeyer Heiner, Suneetha, Pothakamuri Venkata, Grabowski, Jan, Michael Peter Manns, Markus Cornberg, Sarrazin, Christoph, Julia Dietz, Hueseyin Bektas, Christoph Sarrazin, Helfritz Fabian, Schlaphoff, Verena, Lunemann Sebastian, Fabian Helfritz, Suneetha Pothakamuri Venkata, Dietz, Julia, Jaroszewicz, Jerzy, Wedemeyer, Heiner, Bektas Hueseyin, Sebastian Lunemann, Pothakamuri Venkata Suneetha, Sarrazin Christoph, Manns Michael Peter, Jaroszewicz Jerzy, Jerzy Jaroszewicz, Helfritz, Fabian Arnold, Cornberg, Markus, Jan Grabowski, Schlaphoff Verena, Dietz Julia, Manns, Michael P., Verena Schlaphoff, Grabowski Jan, Cornberg Markus   +35 more
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Splenic CD8(+) T cells secrete TGF-beta 1 to exert suppression in mice with anterior chamber-associated immune deviation [PDF]

, 2009
Background CD8(+) regulatory T cells (Treg) have been considered to be involved in a model of ocular-induced tolerance, known as anterior chamber-associated immune deviation (ACAID).
Hao He, Lin, X.M., Peizeng Yang, Jiang, L.Q., Hongyan Zhou, Aize Kijlstra, Liqiong Jiang, Huang, X.K., Yang, P.Z., He, H., Zhou, H.Y., Xiaomin Lin, Xiangkun Huang, Kijlstra, A.   +13 more
core   +1 more source

Cancer immunosurveillance by CD8 T cells [PDF]

F1000Research, 2020
Clinical success attained in patients with cancer treated with checkpoint inhibitors has renewed the interest in the immune system and in particular in T cells as a therapeutic tool to eliminate tumors. Here, we discuss recent studies that evaluate the anti-tumor role of CD8 T cells and the mechanisms that interfere with this function.
José C. Crispín, George C. Tsokos
openaire   +2 more sources

Intratumoral CXCL13+CD8+T cell infiltration determines poor clinical outcomes and immunoevasive contexture in patients with clear cell renal cell carcinoma

Journal for ImmunoTherapy of Cancer, 2021
Background Chemokine (C-X-C motif) ligand 13 (CXCL13) was known as a selective chemotaxis for B cells, a product of follicular helper CD4+T cells (TFH) and a contributor to tertiary lymphoid structures (TLS).
Jiejie Xu, Yu Xia, Ying Xiong, Yu Zhu, Zewei Wang, Han Zeng, Zhaopei Liu, Jiajun Wang, Yuan Chang, Le Xu, Qi Bai, Jianming Guo, Siyuan Dai, Kaifeng Jin, Wenbin Jiang, Zhiyuan Lin, Yang Qu   +16 more
doaj   +1 more source

Swift development of protective effector functions in naive CD8(+) T cells against malaria liver stages. [PDF]

, 2001
We generated T cell receptor transgenic mice specific for the liver stages of the rodent malaria parasite Plasmodium yoelii and studied the early events in the development of in vivo effector functions in antigen-specific CD8(+) T cells.
Lafaille, JJ, Gen-ichiro Sano, Alexandre Morrot, Abe, R, Juan J. Lafaille, Fidel Zavala, Sano, G, Ryo Abe, Julius C.R. Hafalla, Hafalla, JC, Morrot, A, Zavala, F   +11 more
core   +1 more source

CD8⁺ T regulatory cells in lupus [PDF]

Rheumatology and Immunology Research, 2021
Abstract T regulatory cells (Tregs) have a key role in the maintenance of immune homeostasis and the regulation of immune tolerance by preventing the inflammation and suppressing the autoimmune responses. Numerical and functional deficits of these cells have been reported in systemic lupus erythematosus (SLE) patients and mouse models of
Singh, Ram P., Bischoff, David S., Hahn, Bevra H.   +2 more
openaire   +2 more sources

Modulation of the CD8+-T-cell response by CD4+ CD25+ regulatory T cells in patients with Hepatitis B virus infection [PDF]

, 2005
CD4+ CD25+ regulatory T cells have been shown to maintain peripheral tolerance against self and foreign antigens. In this study we analyzed the effect of circulating CD4+ CD25+ T cells on CD8+-T-cell responses of patients with chronic and resolved ...
Gotto, J, Ornella Franzese, Antonio Bertoletti, Maini, Mk, Franzese, O., Williams, R., Adam J. Gehring, Gehring, A.J., Roger Williams, Gehring, Aj, Gotto, J., Bertoletti, A., Kennedy, P.T.F., Williams, R, Maini, M.K., Patrick T. F. Kennedy, Kennedy, Ptf, Jim Gotto, Mala K. Maini, FRANZESE, ORNELLA   +19 more
core   +1 more source

Prognostic values of tissue-resident CD8+T cells in human hepatocellular carcinoma and intrahepatic cholangiocarcinoma

World Journal of Surgical Oncology, 2023
Background Tissue-resident CD8+T cells (CD103+CD8+T cells) are the essential effector cell population of anti-tumor immune response in tissue regional immunity. And we have reported that IL-33 can promote the proliferation and effector function of tissue-
Lujun Chen, Hao Huang, Ziyi Huang, Junjun Chen, Yingting Liu, Yue Wu, An Li, Junwei Ge, Zhang Fang, Bin Xu, Xiao Zheng, Changping Wu   +11 more
doaj   +1 more source

Mitochondria dysfunction in CD8+ T cells as an important contributing factor for cancer development and a potential target for cancer treatment: a review

Journal of Experimental & Clinical Cancer Research, 2022
CD8+ T cells play a central role in anti-tumor immunity. Naïve CD8+ T cells are active upon tumor antigen stimulation, and then differentiate into functional cells and migrate towards the tumor sites.
Lu Zhang, Wen Zhang, Ziye Li, Shumeng Lin, Tiansheng Zheng, Bingjie Hao, Yaqin Hou, Yanfei Zhang, Kai Wang, Chenge Qin, Liduo Yue, Jing Jin, Ming Li, Lihong Fan   +13 more
doaj   +1 more source

CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection

Cell Reports, 2021
Summary: CD4 T cells are essential for immunity to tuberculosis because they produce cytokines, including interferon-γ. Whether CD4 T cells act as “helper” cells to promote optimal CD8 T cell responses during Mycobacterium tuberculosis is unknown.
Yu-Jung Lu, Palmira Barreira-Silva, Shayla Boyce, Jennifer Powers, Kelly Cavallo, Samuel M. Behar   +5 more
doaj   +1 more source