Results 21 to 30 of about 471,511 (315)
Cancer immunosurveillance by CD8 T cells [PDF]
F1000Research, 2020 Clinical success attained in patients with cancer treated with checkpoint inhibitors has renewed the interest in the immune system and in particular in T cells as a therapeutic tool to eliminate tumors. Here, we discuss recent studies that evaluate the anti-tumor role of CD8 T cells and the mechanisms that interfere with this function.
José C. Crispín, George C. Tsokos
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Swift development of protective effector functions in naive CD8(+) T cells against malaria liver stages. [PDF]
, 2001 We generated T cell receptor transgenic mice specific for the liver stages of the rodent malaria parasite Plasmodium yoelii and studied the early events in the development of in vivo effector functions in antigen-specific CD8(+) T cells.
Lafaille, JJ +11 more
core +1 more source
Cell Reports, 2021 Summary: CD4 T cells are essential for immunity to tuberculosis because they produce cytokines, including interferon-γ. Whether CD4 T cells act as “helper” cells to promote optimal CD8 T cell responses during Mycobacterium tuberculosis is unknown.
Yu-Jung Lu +5 more
doaj +1 more source
Inflaming the CD8+ T Cell Response [PDF]
Immunity, 2006 Although inflammatory cytokines induced by infection or vaccination with adjuvants have long been known to stimulate optimal antigen-presenting cell function, recent evidence indicates that some inflammatory cytokines also act directly on the responding T cells to control their response to infection.
Haring, Jodie S. +2 more
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CD8+ T regulatory cells in lupus [PDF]
Rheumatology and Immunology Research, 2021 Abstract T regulatory cells (Tregs) have a key role in the maintenance of immune homeostasis and the regulation of immune tolerance by preventing the inflammation and suppressing the autoimmune responses. Numerical and functional deficits of these cells have been reported in systemic lupus erythematosus (SLE) patients and mouse models of
Singh, Ram P. +2 more
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Efficient development of plasmodium liver stage-specific memory CD8+ T cells during the course of blood-stage malarial infection. [PDF]
, 2007 Immunity to Plasmodium liver stages in individuals in malaria-endemic areas is inextricably linked to concomitant blood-stage parasitemia. Although Plasmodium sporozoite infection induces measurable CD8+ T cell responses, the development of memory T ...
Dabeiba Bernal‐Rubio +9 more
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Modulation of the CD8+-T-cell response by CD4+ CD25+ regulatory T cells in patients with Hepatitis B virus infection [PDF]
, 2005 CD4+ CD25+ regulatory T cells have been shown to maintain peripheral tolerance against self and foreign antigens. In this study we analyzed the effect of circulating CD4+ CD25+ T cells on CD8+-T-cell responses of patients with chronic and resolved ...
Gotto, J +19 more
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World Journal of Surgical Oncology, 2023 Background Tissue-resident CD8+T cells (CD103+CD8+T cells) are the essential effector cell population of anti-tumor immune response in tissue regional immunity. And we have reported that IL-33 can promote the proliferation and effector function of tissue-
Lujun Chen +11 more
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Dual function of the NK cell receptor 2B4 (CD244) in the regulation of HCV-specific CD8+ T cells [PDF]
, 2011 The outcome of viral infections is dependent on the function of CD8+ T cells which are tightly regulated by costimulatory molecules. The NK cell receptor 2B4 (CD244) is a transmembrane protein belonging to the Ig superfamily which can also be expressed ...
Lunemann, Sebastian +35 more
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Journal of Experimental & Clinical Cancer Research, 2022 CD8+ T cells play a central role in anti-tumor immunity. Naïve CD8+ T cells are active upon tumor antigen stimulation, and then differentiate into functional cells and migrate towards the tumor sites.
Lu Zhang +13 more
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