Results 31 to 40 of about 471,511 (315)

Intratumoral CXCL13+CD8+T cell infiltration determines poor clinical outcomes and immunoevasive contexture in patients with clear cell renal cell carcinoma

Journal for ImmunoTherapy of Cancer, 2021
Background Chemokine (C-X-C motif) ligand 13 (CXCL13) was known as a selective chemotaxis for B cells, a product of follicular helper CD4+T cells (TFH) and a contributor to tertiary lymphoid structures (TLS).
Jiejie Xu, Yu Xia, Ying Xiong, Yu Zhu, Zewei Wang, Han Zeng, Zhaopei Liu, Jiajun Wang, Yuan Chang, Le Xu, Qi Bai, Jianming Guo, Siyuan Dai, Kaifeng Jin, Wenbin Jiang, Zhiyuan Lin, Yang Qu   +16 more
doaj   +1 more source

Defining Memory CD8 T Cell [PDF]

Frontiers in Immunology, 2018
CD8 T cells comprising the memory pool display considerable heterogeneity, with individual cells differing in phenotype and function. This review will focus on our current understanding of heterogeneity within the antigen-specific memory CD8 T cell compartment and classifications of memory CD8 T cell subsets with defined and discrete functionalities ...
Matthew D. Martin, Vladimir P. Badovinac, Vladimir P. Badovinac, Vladimir P. Badovinac   +3 more
openaire   +3 more sources

Cytomegalovirus Colitis in Primary Hypogammaglobulinemia With Normal CD4+ T Cells: Deficiency of CMV-Specific CD8+ T Cells

Frontiers in Immunology, 2019
CMV colitis has been reported in immunocompromized patients with severe deficiency of CD4+ T cells and T cell functions. In this study we present an extensive immunological analysis in a patient with primary hypogammaglobulinemia and CMV colitis who had ...
Sudhanshu Agrawal, Amrita Khokhar, Sudhir Gupta   +2 more
doaj   +1 more source

Diversity in CD8+ T cell differentiation [PDF]

Current Opinion in Immunology, 2009
CD8(+) T cells are key effector cells of the adaptive immune system, however their activity must be tightly regulated to allow pathogen clearance whilst preventing immunopathology and autoimmunity. In this review, we summarise the diversity of responses that CD8(+) T cells make to antigenic stimulation with a focus on how CD8(+) T cell responses are ...
Parish, Ian, Kaech, Susan
openaire   +3 more sources

Natural killer cells promote early CD8 T cell responses against cytomegalovirus. [PDF]

, 2007
Understanding the mechanisms that help promote protective immune responses to pathogens is a major challenge in biomedical research and an important goal for the design of innovative therapeutic or vaccination strategies.
Sacher, Torsten, Ulrich H Koszinowski, Rupp Brigitte, Eric Vivier, Ruzsics, Zsolt, Koszinowski Ulrich H, Cornillon, Amélie, Dalod Marc, Bessou Gilles, Koszinowski, Ulrich H, Marc Dalod, Sacher Torsten, Robbins, Scott H., Torsten Sacher, Tomasello Elena, Dalod, Marc, Scott H Robbins, Nicolas Zucchini, Ruzsics Zsolt, Koszinowski, Ulrich H., Zsolt Ruzsics, Elena Tomasello, Gilles Bessou, Bessou, Gilles, Tomasello, Elena, Cornillon Amélie, Vivier Eric, Vivier, Eric, Zucchini, Nicolas, Amélie Cornillon, Brigitte Rupp, Zucchini Nicolas, Robbins, Scott H, Robbins Scott H, Rupp, Brigitte   +34 more
core   +1 more source

CD80 Expressed by CD8+ T Cells Contributes to PD-L1-Induced Apoptosis of Activated CD8+ T Cells

Journal of Immunology Research, 2017
Tumor cells are capable of limiting antitumor CD8+ T cell responses through their cell surface expression of PD-L1. In addition to PD-1 expressed by CD8+ T cells, PD-L1 also binds to CD80 expressed by CD8+ T cells.
Meagan R. Rollins, Rachel M. Gibbons Johnson   +1 more
doaj   +1 more source

Avidity of influenza-specific memory CD8+ T-cell populations decays over time compromising antiviral immunity [PDF]

, 2012
Decline of cell-mediated immunity is often attributed to decaying T-cell numbers and their distribution in peripheral organs. This study examined the hypothesis that qualitative as well as quantitative changes contribute to the declining efficacy of CD8+
James P. Hindley, Ann Ager, van den Berg, Hugo A., McLaren, James Edward, Ladell, Kristin Ingrid, Marsden, Morgan, Hindley, James P., Godkin, Andrew, McLaren, James E., Price, D. A., James E. McLaren, Mathew Clement, Bridgeman, Hayley, Ian R. Humphreys, David A. Price, Hindley, James Philip, Gallimore, Awen Myfanwy, Humphreys, Ian R., Linda Wooldridge, Hugo A. van den Berg, Godkin, Andrew James, Clement, Mathew, Ager, Ann, Berg, Hugo van den, Hayley M. Bridgeman, Kristin Ladell, Andrew Godkin, Awen M. Gallimore, Morgan Marsden, Ladell, Kristin, Smart, Kathryn, Price, David, Kathryn Smart, Bridgeman, Hayley M., Wooldridge, Linda, Gallimore, Awen M.   +35 more
core   +1 more source

Sepsis-induced changes in differentiation, maintenance, and function of memory CD8 T cell subsets

Frontiers in Immunology, 2023
Formation of long-lasting memory lymphocytes is one of the foundational characteristics of adaptive immunity and the basis of many vaccination strategies.
Mohammad Heidarian, Thomas S. Griffith, Thomas S. Griffith, Vladimir P. Badovinac, Vladimir P. Badovinac   +4 more
doaj   +1 more source

IL-4 receptor expression on CD8+ T cells is required for the development of protective memory responses against liver stages of malaria parasites. [PDF]

, 2005
IL-4 receptor (IL-4R)-deficient CD8+ T cells specific for the circumsporozoite protein of Plasmodium yoelii develop a severely impaired memory response after priming with parasites.
Morrot, Alexandre, Alexandre Morrot, Fidel Zavala, Hafalla, Julius CR, Cockburn, Ian A, Carvalho, Luzia H, Zavala, Fidel, Julius C.R. Hafalla, Luzia H. Carvalho, Ian A. Cockburn   +9 more
core   +1 more source

Interleukin-7 regulates CD127 expression and promotes CD8+ T cell activity in patients with primary cutaneous melanoma

BMC Immunology, 2022
Background Interleukin (IL)-7 signaling through CD127 is impaired in lymphocytes in cancers and chronic infections, resulting in CD8+ T cell exhaustion. The mechanisms underlying CD8+ T cell responses to IL-7 in melanoma remain not completely elucidated.
Hongxia He, Binjun Qiao, Shuping Guo, Hongzhou Cui, Ziyan Zhang, Junxia Qin   +5 more
doaj   +1 more source