Results 31 to 40 of about 411,131 (265)

Dichotomous Roles of Programmed Cell Death 1 on HIV-Specific CXCR5+ and CXCR5− CD8+ T Cells during Chronic HIV Infection

Frontiers in Immunology, 2017
BackgroundCXCR5+CD8+ T cells have been demonstrated to play an important role in the control of chronic viral replication; however, the relationship between CXCR5+CD8+ T cells, HIV disease progression, and programmed cell death 1 (PD-1) expression ...
Yan-Mei Jiao, Hong-Ge Yang, Hui-Huang Huang, Bo Tu, Shao-Jun Xing, Lin Mao, Wei Xia, Ran He, Ji-Yuan Zhang, Ruo-Nan Xu, Lei Jin, Ming Shi, Zhe Xu, En-Qiang Qin, Xi-Cheng Wang, Hao Wu, Lilin Ye, Fu-Sheng Wang   +17 more
doaj   +1 more source

Attrition of memory CD8 T cells [PDF]

Nature, 2009
An important role for the immune system is to maintain protective immunological memory to a wide variety of pathogens encountered over one's lifetime, while still leaving the host able to respond to newly encountered pathogens. Vezys et al. make the interesting observation that it is possible to repeatedly immunize mice in ways that allow for ...
Raymond M, Welsh, Liisa K, Selin
openaire   +2 more sources

HIV-Specific CD8+ T Cells Exhibit Reduced and Differentially Regulated Cytolytic Activity in Lymphoid Tissue

Cell Reports, 2017
Summary: Elimination of lymphoid tissue reservoirs is a key component of HIV eradication strategies. CD8+ T cells play a critical role in control of HIV, but their functional attributes in lymph nodes (LNs) remain unclear.
Morgan A. Reuter, Perla M. Del Rio Estrada, Marcus Buggert, Constantinos Petrovas, Sara Ferrando-Martinez, Son Nguyen, Alberto Sada Japp, Yuria Ablanedo-Terrazas, Amaranta Rivero-Arrieta, Leticia Kuri-Cervantes, Heidi M. Gunzelman, Emma Gostick, David A. Price, Richard A. Koup, Ali Naji, David H. Canaday, Gustavo Reyes-Terán, Michael R. Betts   +17 more
doaj   +1 more source

Tissue-Resident Memory-Like CD8+ T Cells Exhibit Heterogeneous Characteristics in Tuberculous Pleural Effusion

Journal of Immunology Research, 2021
Tissue-resident memory T (TRM) cells are well known to play critical roles in peripheral tissues during virus infection and tumor immunology. Our previous studies indicated that CD69+CD4+ and CD69+CD8+ T cells in tuberculous pleural effusion (TPE) were ...
Sifei Yu, Suihua Lao, Binyan Yang, Changyou Wu   +3 more
doaj   +1 more source

A Subset of CXCR5+CD8+ T Cells in the Germinal Centers From Human Tonsils and Lymph Nodes Help B Cells Produce Immunoglobulins

Frontiers in Immunology, 2018
Recent studies indicated that CXCR5+CD8+ T cells in lymph nodes could eradicate virus-infected target cells. However, in the current study we found that a subset of CXCR5+CD8+ T cells in the germinal centers from human tonsils or lymph nodes are ...
Juan Shen, Xi Luo, Qiongli Wu, Jun Huang, Guanying Xiao, Liantang Wang, Binyan Yang, Huabin Li, Changyou Wu   +8 more
doaj   +1 more source

Phenotype and molecular signature of CD8+ T cell subsets in T cell- mediated rejections after kidney transplantation.

PLoS ONE, 2020
We investigated the phenotype and molecular signatures of CD8+ T cell subsets in kidney-transplant recipients (KTRs) with biopsy-proven T cell-mediated rejection (TCMR).
Eun Jeong Ko, Jung-Woo Seo, Kyoung Woon Kim, Bo-Mi Kim, Jang-Hee Cho, Chan-Duck Kim, Junhee Seok, Chul Woo Yang, Sang-Ho Lee, Byung Ha Chung   +9 more
doaj   +1 more source

HIV-1-Specific CD11c+ CD8+ T Cells Display Low PD-1 Expression and Strong Anti-HIV-1 Activity

Frontiers in Immunology, 2021
Exhaustion of HIV-1-specific CD8+ T cells prevents optimal control of HIV-1 infection. Identifying unconventional CD8+ T cell subsets to effectively control HIV-1 replication is vital. In this study, the role of CD11c+ CD8+ T cells during HIV-1 infection
An-Liang Guo, An-Liang Guo, Jin-Fang Zhao, Lin Gao, Lin Gao, Hui-Huang Huang, Ji-Yuan Zhang, Chao Zhang, Jin-Wen Song, Ruo-Nan Xu, Xing Fan, Ming Shi, Yan-Mei Jiao, Fu-Sheng Wang   +13 more
doaj   +1 more source

CD40L Expression Allows CD8+ T Cells to Promote Their Own Expansion and Differentiation through Dendritic Cells

Frontiers in Immunology, 2017
CD8+ T cells play an important role in providing protective immunity against a wide range of pathogens, and a number of different factors control their activation.
Neil Q. Tay, Neil Q. Tay, Neil Q. Tay, Debbie C. P. Lee, Debbie C. P. Lee, Yen Leong Chua, Yen Leong Chua, Nayana Prabhu, Nayana Prabhu, Nicholas R. J. Gascoigne, Nicholas R. J. Gascoigne, David M. Kemeny, David M. Kemeny   +12 more
doaj   +1 more source

Persistent CD8 T Cell Marks Caused by the HCMV Infection in Seropositive Adults: Prevalence of HLA-E-Reactive CD8 T Cells

Cells, 2023
This study investigated the frequency and peptide specificity of long-lasting HCMV-specific CD8 T cells in a cohort of 120 cytomegalovirus seropositive (HCMV+) healthy carriers with the aim of deciphering the relative contribution of unconventional HLA-E-
Amélie Rousselière, Béatrice Charreau
doaj   +1 more source

PD-L1+CD8+ T cells enrichment in lung cancer exerted regulatory function and tumor-promoting tolerance

iScience, 2022
Summary: Immunotherapy targeting checkpoint blockade to rescue T cells from exhaustion has become an essential therapeutic strategy in treating cancers. Till now, little is known about the PD-L1 graphic pattern and characteristics in CD8+ T cells.
Yingxia Zheng, Li Han, Zheyi Chen, Yiyang Li, Bingqian Zhou, Rui Hu, Shiyu Chen, Haibo Xiao, Yanhui Ma, Guohua Xie, Junyao Yang, Xianting Ding, Lisong Shen   +12 more
doaj   +1 more source