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Serum CD95 of relapsing remitting multiple sclerosis patients protects from CD95-mediated apoptosis
Journal of Neuroimmunology, 1998Failure of CD95-mediated apoptosis as a potential negative regulatory mechanism of T cell expansion may be involved in T cell-mediated autoimmune diseases such as multiple sclerosis (MS). Recently, soluble CD95 has been shown to be elevated in MS patients with active disease.
F, Zipp +4 more
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Dysregulation of CD95/CD95 Ligand-Apoptotic Pathway in CD3+ Large Granular Lymphocyte Leukemia
Blood, 1998AbstractCD95 (Fas)-induced apoptosis plays a critical role in the elimination of activated lymphocytes and induction of peripheral tolerance. Defects in CD95/CD95L (Fas-Ligand)-apoptotic pathway have been recognized in autoimmune lymphoproliferative diseases (ALPS) and lpr or gld mice and attributed to CD95 and CD95L gene mutations, respectively. Large
T, Lamy +4 more
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1997
CD95 (Fas/APO-1) is a 45 kD cell surface glycoprotein and member of the tumor necrosis factor receptor superfamily (Nagata and Golstein 1995; Itoh et al. 1991; Oehm et al. 1992; Watanabe-Fukunaga et al. 1992a; Smith et al. 1994). Although CD95 is expressed in many tissues including liver, heart, gut, skin and ovaries (Watanabe-Fukunaga et al.
Richard C. Duke +7 more
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CD95 (Fas/APO-1) is a 45 kD cell surface glycoprotein and member of the tumor necrosis factor receptor superfamily (Nagata and Golstein 1995; Itoh et al. 1991; Oehm et al. 1992; Watanabe-Fukunaga et al. 1992a; Smith et al. 1994). Although CD95 is expressed in many tissues including liver, heart, gut, skin and ovaries (Watanabe-Fukunaga et al.
Richard C. Duke +7 more
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Fas/Apo-1 (CD95)-Mediated and CD95-Independent Apoptosis of Malignant Plasma Cells
Leukemia & Lymphoma, 1996CD95 (Fas/Apo-1) mediates apoptosis in cells of various types. Expression of CD95 and its function were investigated in myeloma cells and most plasma cell lines have been found to be CD95-positive. Anti-CD95 antibody induced apoptosis in these cell lines in a manner dependent on intensity of CD95 expression.
H, Hata +3 more
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CD95 Expression and Apoptosis during Pediatric HIV Infection: Early Upregulation of CD95 Expression
Clinical Immunology and Immunopathology, 1998Pediatric HIV infection is characterized by a progressive decline in CD4 T lymphocytes and faster disease progression than is typically seen in adults. Apoptosis, possibly mediated through the CD95 antigen, has been proposed as a mechanism for cell loss which eventually leads to immune dysfunction. In this study of peripheral blood lymphocytes from HIV-
T W, McCloskey +5 more
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