Results 171 to 180 of about 6,938 (195)

Tumor expression of Fas ligand (CD95L) and the consequences

Current Opinion in Immunology, 1998
Tumors of diverse origin have recently been shown to express CD95 ligand and to induce apoptosis in CD95-expressing targets in vitro; however, in vivo, enhanced tumor growth and rejection have both been observed as a consequence of either immunosuppressive or proinflammatory functions of CD95 ligand.
P R, Walker, P, Saas, P Y, Dietrich
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Regulation of the Proinflammatory Effects of Fas Ligand (CD95L)

Science, 1998
Fas ligand (CD95L) inhibits T cell function in immune-privileged organs such as the eye and testis, yet in most tissues CD95L expression induces potent inflammatory responses. With a stably transfected colon carcinoma cell line, CT26-CD95L, the molecular basis for these divergent responses was defined.
J J, Chen, Y, Sun, G J, Nabel
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Atypical Immune Functions of CD95/CD95L

2017
The receptor CD95 (also named Fas or APO-1) is a member of the tumor necrosis factor receptor (TNF-R) superfamily. Its cognate ligand, CD95L, is implicated in immune homeostasis and immune surveillance. Mutations of this receptor or its ligand lead to autoimmune disorders such as systemic lupus erythematosus (SLE) and to cancers; hence, CD95 and CD95L ...
Amanda Poissonnier, Patrick Legembre
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Nitric oxide inhibits apoptosis via AP-1-dependent CD95L transactivation.

Cancer research, 2000
Several inducers of cytotoxic stress promote apoptotic cell death, which, at least in some cases, involves the CD95/CD95 ligand (CD95L) pathway. The induction of the CD95/CD95L pathway can be activated by the activator protein-1 (AP-1)-mediated up-regulation of the CD95L promoter, which is responsible for the induction of apoptosis elicited by stimuli ...
MELINO, GENNARO, BERNASSOLA, FRANCESCA, CATANI, MARIA VALERIA, ROSSI, ANTONELLO, CORAZZARI, MARCO, Sabatini, S, Vilbois, F, Green, DR   +7 more
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CD95–CD95L: can the brain learn from the immune system?

Trends in Neurosciences, 1998
Members of the tumor necrosis factor/nerve growth factor receptor superfamily of cell-surface molecules can play the dual role of mediating either cytotoxicity or cell survival, both in the immune system and in the nervous system. A member of this superfamily, CD95 (also known as ApoI or Fas), was initially identified in the immune system and has been ...
Becher, B, Barker, P A, Owens, T, Antel, J P   +3 more
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Apoptosis in neuroblastomas induced by interferon-? involves the CD95/CD95L pathway

Medical and Pediatric Oncology, 2001
The CD95/CD95 ligand (CD95L) system is a key regulator of apoptosis. To evaluate a possible role of the CD95/CD95L system in human neuroblastoma (NB) cells, we investigated the constitutive and interferongamma (INFgamma)-induced expression of CD95 and CD95L, and CD95-mediated cell death in the SK-N-BE(2) cell line.Modulation of CD95/CD95L expression ...
Annicchiarico-Petruzzelli, M., Bernassola, F., Lovat, P.E., Redfern, C.P.F., Pearson, A.D.J., Melino, G.   +11 more
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Interferon-α enhances CD95L-induced apoptosis of human malignant glioma cells

Journal of Neuroimmunology, 1998
CD95 ligand (CD95L)-induced apoptosis is a novel immunotherapeutic approach to malignant glioma. Here, we report that interferon-alpha (IFN-alpha) sensitizes LN-229 and T98G human malignant glioma cells to CD95L-induced apoptosis. In contrast to the effects of IFN-gamma and TNF-alpha which sensitize glioma cells to CD95 antibody-induced apoptosis in ...
W, Roth, B, Wagenknecht, J, Dichgans, M, Weller   +3 more
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Expression of Fas (CD95) and FasL (CD95L) in Human Airway Epithelium

American Journal of Respiratory Cell and Molecular Biology, 1998
The cell surface molecule Fas (CD95) is a member of the tumor necrosis factor receptor family. Ligation of the Fas receptor can lead to induction of apoptosis in inflammatory cells. It has been suggested that expression of the Fas receptor and its ligand (FasL) in airway epithelium may modulate the inflammatory response commonly found in asthmatic ...
K J, Hamann, D R, Dorscheid, F D, Ko, A E, Conforti, A I, Sperling, K F, Rabe, S R, White   +6 more
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Abstract 4391: CD95L mRNA is toxic to cancer cells

Cancer Research, 2018
Abstract CD95/Fas ligand (CD95L) is best characterized for its role in activating extrinsic apoptosis through binding to its receptor, CD95. However, we recently reported that the CD95L mRNA is enriched in sequences that when converted to si- or shRNAs kill cancer cells through an RNAi-dependent mechanism.
William Putzbach, Ashley Haluck-Kangas, Quan Gao, Aishe A. Sarshad, Elizabeth Bartom, Austin Stults, Abdul S. Qadir, Denise M. Scholtens, Markus Hafner, Marcus Peter   +9 more
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Extracellular matrix interacts with soluble CD95L: Retention and enhancement of cytotoxicity

Nature Immunology, 2001
Fas ligand (CD95L) is synthesized both on the cell surface membrane and in a soluble form. Although CD95L contributes to immune privilege in the cornea and testis, the functions of these alternatively processed proteins are not well understood. Some reports suggest that the cytotoxicity of soluble CD95L is insignificant, whereas others show potent ...
K, Aoki, M, Kurooka, J J, Chen, J, Petryniak, E G, Nabel, G J, Nabel   +5 more
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